medicinal_chemistry_..

Transkrypt

ROZWÓJ POTENCJAŁU I OFERTY DYDAKTYCZNEJ POLITECHNIKI WROCŁAWSKIEJ
CHEMISTRY
MEDICINAL CHEMISTRY
II Level – MSc (3 semesters, 120 ECTS)
PROGRAM
3 SEMESTERS
Entry requirements:
MSc
Completed:
Diploma of the I level studies in Chemistry,
Biotechnology, Chemical Technology,
Chemical Engineering
Possible extension:
Studies of the III level (PhD)
Master Thesis,
FinalExam
Graduate:
Medicinal chemistry is a scientific
discipline at the intersection of chemistry
and pharmacology. Medicinal chemistry
involves the identification, synthesis and
development of the compounds suitable
for therapeutic use. Students are
prepared to solve problems in the design
of new drugs, analysis of existing drugs,
their biological properties, and perfom
the structure correlation analysis (QSAR).
They are also trained in synthesis and
structure analysis using the modern
spectroscopic methods.
Projekt współfinansowany ze środków Unii Europejskiej w ramach
Europejskiego Funduszu Społecznego
PLAN OF STUDIES
1st YEAR, SEMESTER 1
Obligatory courses:
N
o.
Code
1
Subject/Module
Theoretical and
computational
chemistry
2
Principles and
practical aspects of
medicinal
chemistry
3
Principles of drug
design
4
Advanced Organic
Chemistry
Contact hours/week
L
T
2
lab
p
s
2
2
1
1
5
Instrumental
Analysis
1
6
Crystallography
2
7
Multistep organic
synthesis
2
8
Physical Organic
Chemistry
1
9
Foreign Language
10
Electives
3
1
4
2
CHS
TSW
ECTS
Form of
Assesment
60
150
5
ET
30
90
3
E
15
60
2
T
15
60
2
T
60
150
5
T
45
120
4
E
30
60
2
T
15
30
2
T
60
90
3
T
30
60
2
T
CHS
TSW
ECTS
Form of
Assesment
Optional courses // Choose one module
No.
Code
Subject/Module
TOTAL
Contact hours/week
L
T
lab
p
s
12
5
7
0
0
360 900
30
2 nd YEAR, SEMESTER 2
Obligatory courses:
No.
Code
Subject/Module
Contact hours/week
L
T
lab
p
s
CHS
TSW
ECTS
Form of
Assesment
1
Spectroscopic
methods in
medicinal
chemistry
2
2
2
Molecular
Modelling
1
2
3
Instrumental drug
Analysis
1
2
4
Retrieval of
technical and
scientific
information
1
60
150
5
ET
60
150
5
T
45
120
4
T
30
60
2
T
45
120
4
E
90
210
7
ET
60
120
4
T
CHS
TSW
ECTS
Form of
Assesment
2
5
Medicinal Natural
Products
1
2
6
Synthetic Organic
Drugs
2
4
7
Research
Laboratory
4
No.
Code
Subject/Module
TOTAL
Contact hours/week
L
T
lab
p
s
7
0
18
0
1
390 930
31
2 nd YEAR, SEMESTER 3
Obligatory courses:
No.
Code
Subject/Module
Contact hours/week
L
1
Polymers in
Medicine
2
2
Inorganic Drugs
2
3
Mathematical
Methods in Drug
Design
1
4
Graduate
Laboratory
5
Graduate Seminar
6
Electives
T
lab
p
s
15
1
3
CHS
TSW
ECTS
Form of
Assesment
30
60
2
T
30
60
2
T
15
60
2
T
225
300
10
T
15
300
10
T
45
120
4
T
No.
Code
Subject/Module
TOTAL
MasterThesis:
L
T
Contact hours/week
L
T
lab
p
s
8
0
15
0
1
CHS
TSW
360 900
ECTS
Form of
Assesment
30
TSW = 360 h 12 ECTS Final Exam: TSW= 240 h 8 ECTS
La
b
p
s
L – Lecture T – Tutorials, l – laboratory, p – project, s – seminar,
CHS
TSW
CHS – Contact Hours (organized), TSW – Total Student Workload (h), E – Exam, T – Test, CW – Course Work
No.
1
2
3
Code
Subject/Module
Combinatorial
Chemistry
Contact hours/week
L
T
lab
p
s
CHS
TSW
ECTS
Form of
Assesment
30
60
2
T
30
90
3
T
30
60
2
T
2
Terminoplogy in
chemistry and
biotechnology
2
Toxicology
1
Code
RETRIEVAL OF SCIENTIFIC AND TECHNICAL INFORMATION
Language: English
Course: Basic
Year (I), semester (1)
Level: II
Optional
Prerequisites:
Teaching:Traditional
Lecturer: prof. W.A. Sokalski
Lecture
Tutorials
Laboratory
Project
Seminar
Hours / sem. (h)
30
Exam / Course work/T:
CW
ECTS
2
Workload (h)
60
Outcome: Critical analysis of scientific and technical information retrieved from literature
and factographic data bases. Writing and editing scientific publications, cv’s, grant
applications.
Contents: Critical analysis techniques of information retrieved from literature (Current
Contents, Science Citation Index, etc.) and factographic (CSD, PDB, Beilstein, etc.)
databases. Writing and editing process of scientific publications, grant applications, CV’s.
Ethical questions in science. Introduction, computer network services, Writing and editing
scientific publications, ISI Current Contents and Science Citation Index databases, Structural
CSD and PDB databases, genetic databases, patent databases, research grants, Job offers and
fellowships, Ethical questions in science, CV’s, Beilstein database
Literature:
1. D. Ridley, Finding Scientific Information, Information Retrieval:, Wiley, 2002.
Code
Advanced organic chemistry
Language: English
Level: II
Prerequisites:
Lecturer: Prof. Jacek Skarżewski
Lecture
Tutorials
Hours / sem. (h)
15
Exam / Course work/T: T
ECTS
2
Workload (h)
30
Course: Advanced
Obligatory
Teaching:Traditional
Laboratory
Project
Seminar
Outcome: Students should understand the reactivity of main groups of organic compounds. They
should be able to apply the mastered mechanisms of organic reactions in order to explain the course
of a moderately complex molecular transformation.
Content:
1. Reaction intermediates, transition state, Hammond postulate
2. Reactions of carbonyl compounds: Alkylation of enolates and enamines
3. Aldol and Claisen condensations. Michael addition.
4. Reactions of organometallic compounds (Li, Mg, Zn,...).
5. Stereocontrolled reactions: diastereo- i enantiostereoselectivity
6. Reactions of organoboron, -silicon, and -tin compounds.
7. Reactions of organophosphorous compounds.
8. Reactions of organic sulfur and selenium compounds.
9. Stoichiometric and catalytic reactions of transition-metal compounds.
10. Radical and carbene reactions
11. Pericyclic reactions.
12. Selective methods for reductions of organic compounds.
13. Selective methods for oxidations of organic compounds.
14. Selective transformations and protections of functional groups. .
Literature
J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry, Oxford, 2000;
J. McMurry, Chemia organiczna, tom 1 – 5, PWN, Warszawa, 2005;
J.; Michael B. Smith, Jerry March, March’s Advanced Organic Chemistry, Wiley, 2000
L. G. Wade, Organic Chemistry, Prentice Hall, Upper Saddle River, NJ, 2006.
Code
Instrumental analysis
Language: English
Level: II
Prerequisites:
Lecturer: S. Bartkiewicz, Ph.D.,D.Sc.
Lecture
Tutorials
Hours / sem. (h)
15
ECTS
2
Workload (h)
30
Course: Basic/Advanced
Obligatory/Optional
Teaching:Traditional/Distance L.
Laboratory
45
T
3
90
Project
Seminar
Outcome: Fundamental knowledge of Instrumental Analysis. The course deals with the
fundamental concepts and applications of instrumental techniques in chemical analysis. The
course covers some optic, spectroscopic, electroanalytical and chromatographic methods of
analysis
Content:
1. Introduction. Signal and noise statistical methods in analytical chemistry: errors,
confidence limits and intervals analysis of variance, regression and correlation
2. Components of Optical Instruments
3. Optical methods
4. An Introduction to Ultraviolet/Visible Molecular Absorption
5. Spectrometry, Molecular Luminescence
6. Applications of Molecular Absorption
7. Electroanalytical Chemistry (Polarography, Potentiometry, Amperometry)
8. An Introduction to Chromatographic Separations, Gas Chromatography and
Chromatography
Liquid
Literature
1.Cygański A., Metody spektroskopowe w chemii analitycznej, WNT 2002, Warszawa.
2. Cygański A., Metody elektroanalityczne, WNT 1995, Warszawa
3. Minczewski J., Marczenko Z., Chemia analityczna, tom 3, Analiza instrumentalna,
PWN 1985, Warszawa
4. Szczepaniak W., Metody instrumentalne w analizie chemicznej, PWN 2004,
Warszawa
5. Szmal Z., Lipiec T., Chemia analityczna z elementami analizy instrumentalnej ,
PZWL, 1997
Code
crystallography
Language: English
Level: II
Prerequisites:
Obligatory/Optional
Teching:Traditional/Distance L.
Lecturer: Prof. Veneta Videnova-Adrabińska, DSc
Lecture
Hours / sem. (h)
30
Exam / Course work/T: E
Tutorials
15
T
Laboratory
Project
Seminar
ECTS
Workload (h)
3
60
1
30
Outcome: Students will be provided with skills in crystal growing and with competence in
crystal structure determination. The student should be acquainted with different diffraction
techniques and familiar with structural data bases. They should be able to use this knowledge
for solving of various analytical and structural problems in chemistry.
Content:
1. Crystal lattices and lattice parameters: edges, directions, planes, unit cell, atom indexes
2. Crystal symmetry and crystal structure: symmetry elements, symmetry operations, point
groups, space groups, crystal families and crystal systems; fourteen Bravais lattices.
3. Diffraction and crystal structure: geometry of X-Ray diffraction, interference by onedimensional lattice - the Laue equation, lattice planes and the Bragg equation, higher orders of
diffraction, quadratic form of the Bragg equation; reciprocal lattice, the Ewald construction;
the intensities of diffracted beams; structure factors – the atomic scattering factor, the
structure factor; symmetry and reflection intensities; the temperature factor; symmetry of the
diffraction patterns – the Laue groups;
4. Experimental techniques and X-ray diffraction methods for single crystal measurements:
choice and mounting of a single crystal; the four circle diffractometer, area detector systems
(CCDC cameras); measuring the diffraction patterns of single crystals; reflection profiles and
scan type; structure solution methods (Pattersons methods, direct methods) the method of
least squares for structure refinement, crystallographic R-values.
5. Other methods for structural research: powder X-Ray diffraction method: measuring the
diffraction patterns on polycrystalline probes, determination of the lattice parameters and
Bravais lattice type; electron microscopy and structure images; neutron scattering; electron
scattering; protein crystallography.
6. Crystallization processes and methods for single crystal growth.
7. Depiction of crystal structures: metallic structures, ionic structures and structure building
rules; cation-centered and anion-centered polyhedral representation of crystals, structures as
nets; structural databases.
Literature
1. Z. Bojarski, M. Gigla, K. Stróż, M. Surowiec, „Krystalografia”, PWN 2007.
2. Z. Trzaska Durski, H. Trzaska Durska, „Podstawy Krystalografii”, 2003.
3. Z. Kosturkiewicz, Metody krystalografii, Wydawnictwo Naukowe UAM, 2000.
4. W. Massa, Crystal Structure Determination, Springer, 2004.
5. R.J.D. Tilley, Crystals and Crystal Structures, Wiley, 2006.
6. G. Rhodes, Crystallography made crystal clear, Elsevier, 2006.
Code
Spectroscopic methods in medicinal chemistry
Language: English
Level: II
Obligatory/Optional
Teaching:Traditional/Distance
Prerequisites: Physics, Physical Chemistry
L.
Lecturers: R.Gancarz, prof, R.Latajka Dsc
Lecture
Tutorials
Laboratory
Project
Seminar
Hours / sem. (h)
30
2
CW
ECTS
3
2
Workload (h)
60
60
Outcome: Basic knowledge of spectroscopy and practical knowledge of essential
spectroscopic techniques.
Contents: Introduction to NMR spectroscopy – nucleus spin in magnetic field, chemical shift
and spin-spin coupling, 1H NMR spectroscopy NMR spectroscopy – 1D spectra parameters –
chemical shifts and factors which influence on it, coupling constants type H-X and X-Y and
their influence on structure of molecules, 13C and 31P NMR spectroscopy. Application of
NMR spectroscopy in structural and conformational studies of biomolecules – 2D spectra –
COSY, TOCSY, HSQC, HMBC, NOESY, ROESY. Magnetic Resonance Imaging. Mass
spectrometry – introduction, types of ionization and analyzers, connection with GC and LC,
fragmentation. Mass spectrometry – comparison of macromolecules’ method of investigation
– FAB, MALDI and ESI. IR spectroscopy – interpretation of spectra, basic absorption bands,
application in structural studies – hydrogen bonding, Introduction to UV-Vis spectroscopy of
organic compounds, monitoring of chemical reactions, electron spectroscopy in bioinorganic
chemistry – application in coordination chemistry,
CD spectroscopy – theoretical
introduction, application in conformational studies of peptides and metal complexes, EPR
spectroscopy – electron spin in magnetic field, parameters of spectra, application in studies of
free radicals and metal complexes.
Literature:
1. R.M. Silverstein, F.X. Webster „Spectrometric Identification of Organic Compounds“, J.
Wiley&Sons 1996
2. H. Gunther “NMR Spectroscopy”, J. Wiley&Sons, 1994
3. J. M. Hollas, Modern Spectroscopy (Fourth Edition), Wiley & Sons, Ltd, 2004.
4. P.W. Atkins, Physical Chemistry, (Sixth Edition), Oxford University Press, Oxford
Melbourne Tokyo 1998.
Code
theoretical and computational chemistry
Language: English
Level: II
Prerequisites:
Lecturer: Prof. Szczepan Roszak,
Lecture
Hours / sem. (h)
30
ECTS
3
Workload (h)
60
Tutorials
Laboratory
Obligatory/Optional
L.
Project
Seminar
Outcome: Basics of quantum chemistry are presented together with the emphasis of its
practical application. The course provides knowledge of theoretical predictions of properties
for molecules, complexes, and molecular materials, and also modeling of chemical processes.
Content:
1. basic ideas and postulates of quantum mechanics
2. potential energy curves – molecular mechanics, chemical thermodynamics
3.simple model problems, potential barrier, hydrogen bond
4.harmonic oscillator – IR spectroscopy
5.rotator – microwave spectroscopy
6.hydrogen atom, spectroscopy of hydrogen atom
7. variational method
8.orbital approximation, Slater determinant
9. electronic structure of many-electron atoms, periodic table
10.Hartree-Fock method
11.Hartree-Fock-Roothan method
12.ab initio methods; atomic basis functions
13. chemical bond – electron population analysis
14. perturbation theory, intermolecular interactions
15. electron correlation, perspectives of theoretical chemistry
Literature
J. Sadlej, W. Kolos, Atom i Czasteczka, PWN; R. F. Nalewajski, Podstawy i Metody Chemii
Kwantowej, PWN;
L. Piela, Ideas of Quantum Chemistry, PWN; M. A. Ratner, G. C. Schatz, Introduction to
Quantum Mechanics in Chemistry, Prentice Hall; Journal of Chemical Education, J. B.
Foresman, A. Frisch, Exploring Chemistry with Electronic Structure Methods, Gaussian, Inc.
Code
physical organic chemistry
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites:
Lecturer: R.Gancarz, prof, J. Zoń, Ph.D.,D.Sc.
Lecture
Tutorials
Hours / sem. (h)
15
ECTS
2
Workload (h)
30
Laboratory
Project
Seminar
Outcome: The course is supposed to give the basic knowledge of dynamics and energetics of
organic transformations, rate comparisons between families of reactions, dynamic
stereochemistry, conformational analysis, molecular recognition and catalysis.
Content:
1. Stable and strain molecules.
2. Conformational analysis.
3. Electronic effects. Hammett plots.
4. Steric effects. Taft parameters.
5. Molecular mechanics.
6. Solutions and non-covalent binding force.
7. Molecular recognition.
8. Acid-base chemistry.
9. Stereochemistry.
10. Kinetics.
11. Primary and secondary kinetic isotope effects.
12. Reaction mechanism.
13. Catalysis.
14. Materials chemistry.
Literature
Aslyn E.V., Dougherty D.A., “Modern Physical Organic Chemistry”, University Science
Books, Sausalito, California, 2006.
Hammett L.P., „Fizyczna chemia organiczna”, PWN, W-wa, 1976.
Schwetlick K., „Kinetyczne metody badania mechanizmów reakcji”, PWN, W-wa, 1975.
Code
Principles and practical aspects of medicinal chemistry
Language: English
Level: II
Obligatory/Optional
Prerequisites:
L.
Lecturer: Prof. Józef Oleksyszyn
Lecture
Tutorials
Laboratory
Project
Seminar
Hours / sem. (h)
30
Exam / Course work: E
ECTS
3
Workload (h)
60
Outcome Description of the drug market and legal regulations. GMP. Generic drugs. Drug
classification. New drug discovery methods. New experimental therapeutics. Gene therapy.
siRNA. Monoclonal antibodies. New drugs on the market 2002-2006.
Content:
1.Drug market, USA, EU, Poland. Generic drugs
2.Regulations concerning introduction of a new drug on the market
3.New drug discovery methods
4.Combinatorial chemistry
5.Drug classification
6.Enzyme inhibitors
7.Antagonist and agonist of the receptors
8.Drugs interacting with DNA
9.Drug metabolism
10.Prodrugs and drugs delivery systems
11-14. Examples of new drugs on the market 2002-2006
Literature:
The organic chemistry of drug design and drug action – Richard B. Silverman; Academic
Press, Inc., 1992
Comprehensive Medicinal Chemistry, Pergamon Press, 1994
Chemia Leków pod redakcją A. Zejca i M. Gorczycy, Wydawnictwo Lekarskie PZWL,
Warszawa 1999
code
medicinal natural products
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites: Prof. Jadwiga Sołoducho
Lecturer: Prof. Jadwiga Sołoducho
Lecture
Hours / sem. (h)
15
ECTS
2
Workload (h)
30
Tutorials
Laboratory
30
T
2
60
Project
Seminar
Outcome: Students will become familiar with building blocks of herbal metabolic
pathways and herbal secondary metabolism elements with a wide spectrum of properties
(also therapeutic).
Content:
1. Development in phytochemistry and natural products chemistry
2. Biological active compounds in herbs
3. Riches of sulphur compounds in natural products
4. Building blocks
5. Coumarins
6. Flavonoids and stilbenes
7. Terpenoids and steroids
8. Alkaloids
9. Glycosides
10. Anticancer natural products
Literature:
Medicinal natural products, Paul M. Dewick, John Wiley& Sons, LTD 2003; Organic
chemistry, John Mc Murry, PWN, Warszawa 2000
Pharmacognosy, Stanisław Kohlmunzer, PZWL, Warszawa 2000
code
principles of drug design
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites:
Lecturer: Prof. Paweł Kafarski
Lecture
Hours / sem. (h)
15
Exam / Course work: T
ECTS
2
Workload (h)
30
Tutorials
Laboratory
Project
Seminar
Outcome: The techniques of drug design will be presented alongside with critical evaluation
Content:
1. Economical aspects of implementation of research on new drug
2. Short history of drug design
3. Choice of target using AIDS as an example
4. Structural analogy as means of drug design
5. Design of alkylating and suicide enzyme inhibitors
6. Transition state analogues
7. Effectors of metalloenzymes
8. Drug targeting and applicators
code
instrumental drug analysis
Language: English
Level: II
Prerequisites:
Lecturers: Prof. Wiesław Żyrnicki, Marek Pohl, PhD
Lecture
Tutorials
Laboratory
Hours / sem. (h)
15
30
T
ECTS
2
2
Workload (h)
30
60
Obligatory/Optional
L.
Project
Seminar
Outcome: Introduction to the monitoring and analysis of pharmaceutical products.
Knowledge of chemical, physical and biochemical methods used in drug analysis, with a
special attention to spectroscopic and chromatographic techniques. Identification and
quantification of organic and inorganic species. Development of analytical skills in the area
of main and trace components of pharmaceuticals. Quality control and quality assurance.
Content:
1. Introduction to drug analysis
2. Analytical process, procedures and techniques. Analytical figures of merit. Validation
3. Introduction to spectroscopic methods in pharmacy
4. Atomic and molecular spectroscopy methods
5. Methods of structure analysis of drug components (IR, Raman, NMR, XRD)
6. Electrophoresis and chromatography
7. Sample preparation methods. Trends in development of drug analysis
8. Summary. Written test
Literature:
1. Watson D.G., Pharmaceutical Analysis. Churchill Livingston, Edinburgh, 2005
2. Pharmacopeias (US, European, WHO)
3. Kellner R. (Ed.), Analytical Chemistry. John Wiley & Sons, London, 2004
4. Skoog D.A., West D.M., Holler F.J., Fundamentals of Analytical Chemistry.
Saunders College Publishing, 2003
code
synthetic organic drugs
Language: English
Level: II
Prerequisites
Lecturers: : Prof. Roman Gancarz, Izabela Pawlaczyk, PhD
Lecture
Tutorials
Laboratory
Hours / sem. (h)
30
60
T
ECTS
3
4
Workload (h)
60
120
Obligatory/Optional
L.
Project
Seminar
Outcome: Knowledge of fundamental classes of drugs, their mode of action and their
analysis
Content:
1. Reaction mechanisms in organic chemistry and drug action
2. Chirality and biological activity of drug.
3. Drug target binding forces, role of molecular recognition in drug design and drug action.
4. Kinetics and thermodynamics in drug action
5. Proteins as drug targets – enzymes and receptors, peptidomimetics.
6. Drugs acting on carbohydrates and lipids and their metabolism.
7. Drugs acting on DNA and RNA and their metabolism, oligonucleotide therapeutics
8. Cardiovascular agents
9. Drugs affecting hormonal system.
10. Drugs affecting immune system
11. Drugs affecting nervous system.
12. Chemotherapeutic drugs
13 Bio NMR, MS in drug discovery
14 Absorption, distribution, administration and toxicity of drugs, drug metabolism, prodrugs
15. New drugs.
Literature:
The organic chemistry of drug design and drug action – Richard B. Silverman; Academic
Press, Inc., 1992
Comprehensive Medicinal Chemistry, Pergamon Press, 1994
Chemia Leków pod redakcją A. Zejca i M. Gorczycy, Wydawnictwo Lekarskie PZWL,
Warszawa 1999
code
molecular modeling
Language: English
Level: II
Obligatory/Optional
Prerequisites:
L.
Lecturers: Prof. Andrzej Sokalski, Paweł Kedzierski, PhD, Edyta Dyguda-Kazimierowicz,
PhD
Lecture
Tutorials
Laboratory
Project
Seminar
Hours / sem. (h)
15
30
T
ECTS
2
2
1
Workload (h)
30
60
30
Outcome: Basic understanding of computational approaches used to describe and explain the
chemical structure, its properties and structure-function relationships.
Content:
1. Introduction, molecular graphics
2. Molecular model building and visualization
3. Structural databases and their use in molecular modeling
4. Overview of computational techniques of quantum chemistry
5. Elements of the theory of intermolecular interactions
6. Force fields and molecular mechanics
7. Predicting molecular structure, conformational analysis
8. Predicting physical and chemical properties of molecules
9. Modeling of molecular aggregates
10. Modeling chemical reactions
11.Molecular dynamics
12.Drug design techniques
13. Catalyst design techniques
14. Homology modeling
15.Written exam
Literature:
1 Basic literature: A.R.Leach, Molecular Modelling: Principles and Applications (2nd
Edition), Prentice Hall; ISBN: 0582382106, 2001.
2: T. Schlick, Molecular Modeling and Simulation, Springer, 2002
3 L. Piela, Ideas of Quantum Chemistry, Elsevier, 2006
code
research laboratory
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites:
Lecturer: supervisor
Lecture
Hours / sem. (h)
60
ECTS
4
Workload (h)
120
Tutorials
Laboratory
4
Project
Seminar
4th SEMESTER
Code
POLYMERS IN MEDICINE
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites:
Lecturer: Prof. Marek Bryjak
Lecture
Hours / sem. (h)
30
Tutorials
Laboratory
Project
Seminar
ECTS
Workload (h)
2
60
Outcome: Advantages and opportunities to use polymers in biotechnology and medicine.
General overview of polymers, their synthesis, structure and properties, use of polymers in
selected areas? of medical treatment.
Contents: History of polymers, impact of polymers to our life, Polymerisation,
copolymerisation, grafting, plasma polymersation, .Molecular weights, number and weight
averaging, polydispersity, methods of molecular weight evaluation, Solution of polymers.
Flory-Huggins model, Blends of polymers, block copolymers, interpolymers. Phase
transitons, amorphic and semicrystaline polymers .Surface properties of polymers, surface
energetics, methods of surface investigations. Diffusion in polymers, polymer membranes.
Artificial organs (kidney, liver, lung, pancrease). Polymer orthopedic elements, polymers in
dentistry.Tissue engineering, scaffolds, Controlled release drugs, targeted drugs. Polymers
with improved affinity, molecularly imprinted materials. Surgeon materials, smart polymers,
polymers with memory. Polymeric supports and carries for bioactive molecules.
Literature:
1.H.G.Elias, Macromolcules, Plenum Press, New York 1984,
2.L.Sperling, Polymer physicochemistry, Elsevier, New York, 1992
code
inorganic drugs
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites:
Lecturer: prof. Danuta Michalska-Fąk
Lecture
Hours / sem. (h)
30
ECTS
2
Workload (h)
60
Tutorials
Laboratory
Project
Seminar
Outcome: The aim of this course is to review the diagnostic and therapeutic applications of
inorganic compounds (metal complexes and radioisotopes) in medicine. It develops an
understanding of the basic mechanisms of the modern diagnostic techniques: Magnetic
Resonance Imaging (MRI), Positron Emission Tomography (PET), nuclear medicine
(SPECT) and the role played by metallopharmaceuticals in these techniques.
Content:
1. Classification of drugs, Drug discovery, design and development
2. Clinical trials. Development of inorganic drugs.
3. Diagnostic methods: X-ray and application of inorganic contrasts
agents. Magnetic Resonance Imaging (MRI) technique
4. The use of Gadolinium(III) complexes as the T1-type contrast agents
and new T2-contrast agents in MRI and MR angiography techniques.
5. Positron Emission Tomography (PET) and the use of radiotracers:
Fluorine-18, Copper-64, Rubidium-82 and Gallium-68 isotopic
compounds as positron emitters.
6. Nuclear medicine (SPECT) and the use of radionuclides (gamma
emission): Technetium-99m, Gallium-67 and Indium-111 compounds.
7. Therapeutic radiopharmaceuticals (Samarium-153 complex) and
Boron- Neutron Capture Therapy (BNCT).
8. The origin of cancer and various types of chemotherapy
9. Cisplatin and its mechanism of action in anticancer therapy
10. New generations of platinum drugs. Search for an orally active drug
11. Non-platinum compounds in anticancer therapy. Ruthenium
complexes in therapy of cancer metastases.
12. Bismuth compounds in medicine. Activity against Helicobacter pylori
13. Vanadium salts and coordination compounds as insulin mimics
for diabetes treatment
14. Chrysotherapy - gold complexes in treatment of rheumatoid arthritis
15. Perspectives of Medicinal Inorganic Chemistry
Literature:
1.L. Sessler, S. R. Doctrow, T. J. McMurry, S.J. Lippard,
Medicinal Inorganic Chemistry, Oxford University Press, 2005.
2) Concepts and Models in Bioinorganic Chemistry, Ed. H Kraatz, N. Metzler-Nolte,
2006. (review article) by Thompson and Orvig: „Medicinal Inorganic
Chemistry”,
pages 25 - 46.
3 G.L. Patrick, Chemia medyczna. Podstawowe zagadnienia. II wyd. WNT Warszawa,
2003
4) Metallopharmaceuticals I, DNA Interactions, M.J. Clarke, P.J. Sadler , 1999.
5) Metallopharmaceuticals II, Diagnosis and Therapy , M.J. Clarke, P.J. Sadler 1999.
code
mathematical models in drug design
Language: English
Level: II
Prerequisites:
Lecturer: Prof. Roman Gancarz
Lecture
Hours / sem. (h)
15
ECTS
2
Workload (h)
30
Tutorials
Laboratory
Obligatory/Optional
L.
Project
Seminar
Outcome: The goal of the course is to get the knowledge of applying the rational way of drug
design using simple correlation analysis, as well as advanced pattern recognition methods.
Content:
1.Introduction to modelling in science and especially in chemistry
2. Satatistics in data analysis
3. Structural descriptors of molecules
4. Correlation analysis in drug design.
5. Regression medels, Hansh, Kubynyi, Free Wilson approaches
6. Principal component analysis, linear and nonlinear mapping
7. Classification and classifiers, clustering methods,
8. Pattern recognition methods
9. Neural network application in structure property analysis.
Literature:
code
graduate laboratory
Language: English
Level: II
Obligatory/Optional
L.
Prerequisites:
Lecturer: supervisor
Lecture
Tutorials
Hours / sem. (h)
Exam / Course work:
ECTS
Workload (h)
Laboratory
60
T
10
120
code
graduate seminar
Language: English
Level: II
Tutorials
Seminar
Obligatory/Optional
L.
Prerequisites:
Lecturer: Prof. Roman Gancarz
Lecture
Hours / sem. (h)
Exam / Course work:
ECTS
Workload (h)
Project
Laboratory
Project
Seminar
15
T
10
30

medicinal_chemistry_..

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