Polysorbate 80 - Complementary Prescriptions
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Polysorbate 80 - Complementary Prescriptions
Polysorbate 80 DESCRIPTION Polysorbate 80 is commonly used due to its reputation for topically stimulating hair growth in men with male pattern baldness. Used as a shampoo surfactant and a food additive emulsifier, it is often found in mayonnaise, salad dressings, and some liquid detergents. Durk Pearson and Sandy Shaw popularized the use of polysorbate 80 for alopecia in their best-selling book, Life Extension: A Practical Scientific Approach. In their book, Pearson and Shaw report that use of polysorbate 80 in studies has resulted in an average of 60 percent hair regrowth after just six months of daily use. PRODUCT CODE #1100 8 fl. oz. FORMULA For Topical Use Only Polysorbate 80 contains: 100% Polysorbate 80 Histamine-Releaser Although histamine is usually considered the culprit behind seasonal allergies, in actuality this substance is essential for cell growth and reproduction. In fact, since histamine is a growth factor, applying to the scalp a substance that triggers histamine release may also promote hair growth. Polysorbate 80 is known to cause the release of histamine. In animals, administration of polysorbate 80 triggers the production of histamine in mast cells and plasma histamine concentrations rise after administration of polysorbate 80. In humans, the administration of polysorbate 80 causes effects in the body similar to the body's response after histamine administration. REFERENCES 1. Durk Pearson and Sandy Shaw. Life Extension: A Practical Scientific Approach. Pg 218 - 220. Warner Books, Inc. 1982. 2. Masini E, Planchenault J, Pezziardi F, Gautier P, Gagnol JP. Histaminereleasing properties of Polysorbate 80 in vitro and in vivo: correlation with its hypotensive action in the dog. Agents Actions. 1985 Sep;16(6):470-7. One way polysorbate 80 may result in hair regrowth may be through its ability to trigger histamine release in the scalp, stimulating cell growth. Other Possible Mechanisms Polysorbate 80 may also remove dihydrotestosterone (DHT) from the scalp. Excessive levels of DHT are thought to cause hair loss. In addition, polysorbate 80 may affect genetic activities in the hair follicle cells due to its ability to reverse early tissue damage that occurs at the beginning of toxin-induced carcinogenesis. RECOMMENDED DOSAGE In Life Extension, A Practical, Scientific Approach, Pearson and Shaw recommend coating the scalp in the bald or balding locations with a thin film of Polysorbate 80 five or 10 minutes before shampooing. Use a medicine dropper for distribution to the proper areas. Rub the drops into the scalp with the fingertips, preferably vigorously enough for the scalp to turn somewhat red and feel warm, an indication of histamine release. Wait one to three minutes then rinse thoroughly. Within two or three months of daily use, new hairs may appear. Bright side lighting and a black background may be required to see the thin and short hairs that first appear. In some studies, hundreds of men in their 50s and 60s reported more than 60 percent average regrowth after using polysorbate daily for a year. For the first week or two, patients may notice an increase in hair loss due to loosening of hairs in resting phase atrophic follicles. CP ver. 092303 Information contained in this Product Technical Sheet is for educational purposes only and is not intended to provide personal medical advice. Such advice should be obtained from a medical professional. Reproduction of any part of this work is prohibited. © 2003 Complementary Prescriptions™, a division of Vitamin Research Products, Inc.