Praca poglądowa/Review Zespoły mielodysplastyczne (MDS

Praca poglądowa/Review Zespoły mielodysplastyczne (MDS

Praca poglądowa/Review
Zespoły mielodysplastyczne (MDS) – nowe możliwości terapii
Myelodysplastic syndromes (MDS) – new therapy options
Jadwiga Dwilewicz-Trojaczek
Abstract
Myelodysplastic syndromes are heterogeneous clonal disorders of hematopoietic stem cells.
The strategy of the treatment must be based on prognostic scoring systems (IPSS, WPSS,
comorbidities). For lower risk group MDS patients, transfusion dependent, erythropoietic
stimulating agents are first option of treatment. In this group of patients also the first-line
option are lenalidomide and immunosuppressive drugs. In IPSS higher-risk MDS patients the
role of allogeneic stem cell transplantation is well-established. In older patients of this group
the option of treatment are hypomethylating agents. Iron chelation treatment is proposed for
patients with ironoverload. All group of patients should be under supportive care.
Keywords
Myelodysplasic syndromes; Transplantation hematopoietic cells; Erythropoietic stimulating
agents; Lenalidomide; Hypomethylating agents; Chelation drugs