Abstract - Institute of Pharmacology

Pharmacological Reports
Copyright © 2013
2013, 65, 201–207
by Institute of Pharmacology
ISSN 1734-1140
Polish Academy of Sciences
Short communication
Effect of cyclophosphamide and
morin-5’-sulfonic acid sodium salt, alone or in
combination, on ADMA/DDAH pathway in rats
Anna Merwid-L¹d1, Ma³gorzata Trocha1, Ewa Chlebda-Sieragowska1,
Tomasz Sozañski1, Jan Magdalan1, Dorota Ksi¹dzyna1, Andrzej Szuba2,
Maria Kopacz3, Anna KuŸniar3, Dorota Nowak3, Ma³gorzata Pieœniewska1,
Lidia Fereniec-Go³êbiewska1, Adam Szel¹g1
1
Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, PL 50-345 Wroc³aw, Poland
2
Department and Clinic of Internal Medicine and Occupational Diseases, and Hypertension, Wroclaw Medical
University, Pasteura 4, PL 50-367 Wroc³aw, Poland
3
Department of Inorganic and Analytical Chemistry, Chemical Faculty, Rzeszow University of Technology,
Powstañców Warszawy 6, PL 35-959 Rzeszów, Poland
Correspondence: Anna Merwid-L¹d, e-mail: [email protected]
Abstract:
Background: The aim of the study was to evaluate the effect of cyclophosphamide (CPX) and morin-5’-sulfonic acid sodium salt
(NaMSA) on plasma asymmetric dimethylarginine (ADMA) level and dimethylarginine dimethylaminohydrolase (DDAH) activity
in rat liver.
Methods: The study was performed on Wistar rats receiving normal saline, CPX (15 mg/kg/day), NaMSA (100 mg/kg/day) or both
CPX and NaMSA for 10 consecutive days.
Results: Significant decrease in ADMA level was found in all groups when compared to the control. DDAH activity in the liver was
significantly higher in CX group compared to the control group.
Conclusion: Obtained results of ADMA/DDAH pathway parameters require further research.
Key words:
cyclophosphamide, morin-5’-sulfonic acid sodium salt (NaMSA), ADMA, DDAH, rats
Pharmacological Reports, 2013, 65, 201–207
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