docاثر تیمار در تاریکی بر آستانهی تشنج کلونیک و فعالیت صرعی
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اثر تیمار در تاریکی بر آستانهی تشنج کلونیک و فعالیت صرعی
ƱŚºŬƳŻƾĪƃżěƭƺºƬƗƵŚĮºƄƳřŵƾƄƷƹĦěƾưƬƗƽƶƬŬƯ Downloaded from zums.ac.ir at 5:23 IRST on Saturday March 4th 2017 ÐÍŚţÏÏšŚŰƠƇÎÐÕÖŹŚƸŝÔÍƽƵŹŚưƃ ÎÕƽƵŹ ƹŵ ŹŵƩƹŻřźŤţƲƬǀŤƴěŻřƾƃŚƳƾƗźƇŢǀƫŚƘƟƹĨǀƳƺƬĩŪƴƄţƽƶƳŚŤſōźŝ ƾĪƿŹŚţŹŵŹŚưǀţźŧř ƾƷŚĮƄƿŚƯŻōŶǀƠſƁƺƯ èŭLjƟƹŻŹōçƽŶưŰƯřŻźǀƯƶưƏŚƟçƾƳŚƌƯŹŻŚưƫƺſçƽŵřźƯƱřƺǀĩæƾƳŚųŪƴĭƲ ǀƸƯźŤĩŵ [email protected] ƽĥƺƫƺĩŚƯŹŚƟƹƽĥƺƫƺƿżǀƟƵƹźĭƾĪƃżěƽƵŶĪƄƳřŵƱŚŬƳŻ ƩƺŘƀƯƽƵŶƴƀ ƿƺƳ ííîçèƁźƿŸěííëæîŢƟŚƿŹŵ ƵŶǀĪģ żƜƯƞƬŤŴƯƾůřƺƳŹŵƾŞƈƗƽŚƷƩƺƬſƾƘǀŞƏźǀƛƽźƿŸěĨƿźŰţŢǀƬŝŚƣŻřƾƃŚƳ ƽƵŶǀĤǀěƽŹŚŤƟŹƾŞƈƗƩLjŤųřĨƿƖƣřƹŹŵƕźƇ ƝŶƷƹƶƴǀƯŻ ĨǀƳƺƬĩŪƴƄţŻƹźŝŹŵƾĪƿŹŚţŹŵŹŚưǀţƂƤƳƶƘƫŚƐƯƲƿřŹŵƾƿŚƴǀŝźƄƣŹŵƾŞƈƗšŚƏŚŞţŹřƪƯŚĪţƽřźŝƾƀůƽŚƷƽŵƹŹƹƂƤƳƶŝƶū ƺţŚŝŶƃŚŝƾƯ ŢƟźĭŹřźƣƶƘƫŚƐƯŵŹƺƯŶƃŚŝƾƯżƜƯƽźƿŸě ĨƿźŰţźǀǀƜţŻřƾƃŚƳƶĩ Ƶżǀƫřźƴū ŹŵŻƹŹéåŚºţèåšŶºƯƶŝŶƫƺţƱŚƯŻŻřƶĩƾţŚƳřƺǀůƹƩźŤƴĩƵƹźĭšŚƳřƺǀůƶŝŶƇŹŵåêƩƹŻřźŤţƲƬǀŤƴěŪƴƄţƽƶƳŚŤſōƲǀǀƘţŢƸūƾſŹźŝƁƹŹ ŻƹŵŚºŝƹŹřŵƲºƿřƢƿŹżţŻřƾƃŚƳĨǀƳƺƬĩŪƴƄţŻƹźŝƱřżǀƯƾſŹźŝŢƸūƲǀƴĤưƷŶƿŵźĭƢƿŹżţƽŶƿŹƹƪųřŵšŹƺƇƶŝŶƴŤƃřŵŹřźƣƪƯŚĩƾĪƿŹŚţ ƾŝŚºƿŻŹřŵŹƺƯƱōźǀųŚţƱŚƯŻƹƵżǀƫřźƴūĨǀƳƺƬĩŪƴƄţƕƺƣƹƹŶƿŵźĭƢƿŹżţƵƹźĭƹŵźƷšŚƳřƺǀůƶŝƾŤſƺěźƿŻšŹƺƇƶŝƭźĭƺƬǀƧŹŵƭźĭƾƬǀƯíå ŢƟźĭŹřźƣ ƱřżºǀƯŚºƯřŵŹřŶºƳŵƺºūƹƽŹřŵƾƴƘƯƝLjŤųř (DR)ƾĪƿŹŚţŹŵŹŚưǀţƵƹźĭƹƩźŤƴĩƵƹźĭĨǀƳƺƬĩŪƴƄţƽƶƳŚŤſōƲǀŝƶĩŵřŵƱŚƄƳŚƯŪƿŚŤƳŚƷƶŤƟŚƿ ƾºƟLjŤųřĨǀƳƺƬĩĨǀƳƺţŪƴƄţŵŹƺƯŹŵŶƃŚŝƾƯźţLJŚŝƽŹřŵ ƾƴƘƯŹƺƏ ƶŝƵƹźĭƲƿřŹŵŪƴƄţźǀųŚţƱŚƯŻƹźŤưĩDR ƵƹźĭŹŵĨǀƳƺƬĩŪƴƄţƕƺƣƹ ŶƄƳƵŶƿŵƵƹźĭƹŵƲǀŝ ƾƨƿŹŚţŹŵƵŶƃŹŚưǀţšŚƳřƺǀůŹŵŹƺƳŻřŢǀƯƹźŰƯƎſƺţƾƿŚƴǀŝźƄƣŹŵƾƿřŻƕźƇŵřŶƘŤſřƂƿřżƟřźŝƾƴŞƯƽŶƷřƺƃŵƺūƹƮƛŹƾƬƗ ƽźǀĭƶŬǀŤƳ ŶƴƃŚŝƶŤƃřŵƂƤƳƲǀƳƺţLjƯźǀƔƳƾƬƯřƺƗƶƐŝřŹƲƿřŹŵŵŹřŵƩŚưŤůřŵƺƃƾƯƵŶƷŚƄƯŪƴƄţƪŝŚƤƯŹ ŵŢƓŚƠůƾƗƺƳ ƩƹŻřźŤţƲƬǀŤƴěƾĪƿŹŚţŹŵŹŚưǀţƵżǀƫřźƴūĨǀƳƺƬĩŪƴƄţƽŶǀƬĩƱŚĭĥřƹ ƩLjŤºųřĨºƿƕźºƇèŢºſřƶŤųŚƴºƃřŹƱōźƄºŝƶĩŢſř ƶƯŶƤƯ æŢºſř ƾŞƈºƗ ƽŚºƷƽ ŹŚưǀŝƲƿźţƖƿŚƃŻř ƾĪƿ ƕźƇ ƽŚºƷƩƺƬºſƾºƘǀŞƏźǀƛƽƶǀƬŴţƽƶƬǀſƹƶŝƶĩŢſřƽřƵŹƹŵƹ ƾƿŚºƷƽ ŹŚºưǀŝƲƿźºţƾ ưƿŶºƣŻřƾºĪƿƽŹŚºưǀŝƲƿřçŶƴŤƀƷ ƾºƴǀŝƂǀºěƪŝŚƣźǀƛƶƬưůšŹƺƇƶŝƹƵŶƳƹźƄǀěŜƬƛřƹƲƯżƯ LjŤºŞƯƽŹŚưǀŝƲƿřƶŝŚǀƳŵŹŵźƠƳƱƺǀƬǀƯêåŻřƂǀŝƶĩƽ ŹƺƏƶŝ ƱŚŬƳŻƾƨƃżěƭƺƬƗƵŚĮƄƳřŵŹŚƿŵŚŤſřƽĥƺƫƺƿżǀƟƾƈƈŴţƽřźŤƧŵæ ƱŚŬƳŻƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƨƃżěƽƺŬƄƳřŵç ƱŚŬƳŻƾƨƃżěƭƺƬƗƵŚĮƄƳřŵįĥƺƫƺƿżǀƟŶƃŹřŽŚƴƃŹŚĩè ĨǀƳƺƬĩŪƴƄţƹİĪƿŹŚţŹŵŹŚưǀţ ƾƿŚºƴǀŝžĪţŹƺºĩƽżºƜƯƽŚƸºƃźŝŹŵ (PTX)ƲǀƀĩƺţƹźĪǀě ĨºƿƽŹŚºưǀŝƲºƿřƖºƣřƹŹŵéŵƺºƃƾ ºƯŵŚºŬƿřżƜƯƾŞƈƗ ŢºſřƚƫŚºŝŚƳžĪţŹƺºĩƺŘƳŹŵ ƾƗźºƇũřƺºƯřƕƹźƃ ƽƶƳŚŤſō ŶºƃŚŝƾºƯżƜƯƞƬŤŴƯƾůřƺƳŹŵƾŞƈƗƽŚƷƩƺƬſ ƾƘǀŞƏźǀƛ ƱŵƺºŝƲǀƿŚºěŻř ƾĩŚºůƞºƬŤŴƯšŚƘƫŚƐƯæèŵƺƃƾ ƯšřŹ ƂƿřżƟřšŹƺƇƶŝžĪţŹƺĩƺŘƳƽƶǀƫƹřŶƃŹŶƫƺţŻřžěæé ƮŤƀºǀſƱōŚºŝƱŚºƯŻƮƷƹŶƴĩƾ ƯŻƹźŝƾĪƿźŰţƮŤƀǀſŢƣƺƯ Downloaded from zums.ac.ir at 5:23 IRST on Saturday March 4th 2017 23 ŹŵæêŶººƴĩŶººƃŹƾŤƀººƿŚŝƵŵƺººŝƆƣŚººƳŻƺººƴƷƽŹŚººƸƯ ƾººĪƿźŰţƾƀººěŚƴǀſžººěƽŚººƷƪ ǀƀººƳŚŤěšřŹžĪţŹƺººĩƺŘƳ Źŵ[Excitatory Post Synaptic Potential (EPSP)] ƽźƿŸºěĨƿźŰţŢǀƬŝŚƣŻřƾƃŚƳƵŶǀĤǀěƽŹŚŤƟŹƾŞƈƗƩLjŤųř ƶºĩŢºſřŪƴƄţŹŚƸƯšŹƺƇƶŝŚƯƺưƗƕźƇŪƿřŹƱŚƯŹŵê ƽŚºƷƹŹřŵźŨĩřƶƳŚƠſŚŤƯƾƫƹŢſřƽŹŚưǀŝƲƿřƾƬƇřƮƿLjƗŻř ƽŵřŶƘţƲǀƴĤưƷëŶƳŹřŵ ƾƿƺſ ƾŞƳŚūƉŹřƺƗŪƴƄţŶƋ ŲºſŚěƹŶƴŤƀºƷƭƹŚºƤƯƩƹřŶºŤƯƽŚƷƹŹřŵƶŝŢŞƀƳƱřŹŚưǀŝŻř ŚƿƲƯżƯƕźƇƶŝźŬƴƯƶĩƾĪƿĥƺƫƺƿżǀƟƺţŚěƮƀǀƳŚĪƯŶƴƷŵƾ ưƳ ƽŚºƷžěŚƴ ǀºſŚºƯřŶºƳřƵŵƺ ºưƳŶºƃŹŶºƫƺţŻřžěƭƹŵƽƶŤƠƷ ŢºſřƵŶƄºƳƶŤųŚƴºƃƾŤºſŹŵƶºŝŻƺºƴƷŵƺƃƾ ƯŹŚƸƯƪŝŚƣźǀƛ ƪºŞƣŚţ[Inhibitory Post Synaptic Potentials (IPSP)] řŹƾºƿƹŹřŵƽŚƷƱŚƯŹŵżǀƳƹ ƾƫŚưŤůř ƽźǀĮƄǀěƽĥƺƫƺƿżǀƟƺţŚě ƽŹŚºººƸƯƾƀºººěŚƴǀſžºººěƽŚºººƷƪ ǀƀºººƳŚŤěżº ºǀƳƹƱŹŚºººƤŤƯ źŝƾƀěŚƴǀſšŹŶƣLJƺƇřŶƃŶƴƷřƺŴƳƪƯŚĩƭŹŚƸģƽƶŤƠƷŻř ƾŤǀƀºǀŤſLjěŶºƃŚŝƾ ºƯźǀƜŤƯžěŚƴǀſƱōŢǀƫŚƘƟƱřżǀƯŽŚſř ƾŞƈºƗšŚºƗLjƏřƁŻřŵźěŹŵŚƸƴţƶƳžěŚƴǀſĨƿšŶƯƵŚţƺĩ ŢſřŢǀưƷřżŗŚůżǀƳŹŚƸƯƹĨƿźŰţƩŵŚƘţƽŹřźƣźŝŹŵƶĪƬŝ ƾºƘǀŞƏŵźºĪƬưƗŢºƸūŹŚºƸƯƹĨºƿźŰţƲǀºŝƩŵŚºƘţŵƺūƹ ŢººƔƟŚŰƯŜººūƺƯƹŢººſřƽŹƹźººƋżººƜƯźƄººƣƽŚƷŹřŶººƯ æëƹæìŵƺƃƾ ƯŪƴƄţƪŝŚƤƯŹŵƾŞƈƗƽŚƷƶĪŞƃ ƾºƘǀŞƏŶƃŹƽřźŝƾƀůśŹŚŬţƶĩŢſřƱōŻřƾĩŚůŶƷřƺƃ ƾĪƿŹŚţŹŵšŚƳřƺǀůƱŵřŵŹřźƣŢſřƽŹƹźƋƾƿŚƴǀŝžĪţŹƺĩ ƱŚºǀƯƲºƿřŹŵƹŵƺºƃƾ ºƯŚºƷƱōŹŵƾºƘǀŞƏƙƺƬŝŹŚƸƯŜūƺƯ ƹŶºƳźǀĭƾ ƯŹřźƣƪưƗƲƿřźǀŧŚţŢŰţźŤƄǀŝƽŹŚƸƯƽŚƷƱƹŹƺƳ Ŷºƴĩƾ ºƯřŶǀěƪƿŚưţŚƷƾ ĪƿźŰţŢưſƶŝŚƷƽ ŵƹŹƹƲƿřƩŵŚƘţ ŻřŢºǀƯƹźŰƯźºŧřƽƶºƴǀƯŻŹŵŵƺūƺƯ ƽŚƷƁŹřżĭƶŝƶūƺţŚŝ ƾƴǀŝƂ ǀěƱřƺţƾ ƯƱŚĭŶƳƺūŵřŻƺƳƽżƜƯƽŚƷŹřŶƯŶƃŹŹŵŹƺƳ źƄºƣƽŚºƷƱƹŹƺºƳŹŵƾƿřŻƕźƇŵřŶƘŤſřŢǀƘƋƹƲƿřƶĩŵźĩ ƶºĩŢſřƲƿřŚƯƩřƺſƩŚůƹŵźŞŝLJŚŝřŹšřŵƺūƺƯƲƿřƾƿŚƴǀŝ ƽźºŧř(GC) ĨǀƳƺƬĩƵżǀƫřźƴūƕźƇŵŚŬƿřŹŵŢǀƘƋƹƲƿřŚƿō ƢºǀƤŰţ ƩřƺºſƲºƿřƶºŝŲſŚěŹƺƔƴƯƶŝźǀųŚƿŢƃřŵ ŶƷřƺų ƾƨƿŹŚºţŹŵŹŚºưǀţ ƾƫŚưŤůřźŧř ŚţŢſřƵŶƿŵźĭ ƾůřźƏźƋŚů ŚºƿƕƺºƣƹżǀƳƹƵżǀƫřźƴūŪƴƄţƽƶƳŚŤſōźŝ Dark Rearing ƽƶƴǀƯŻŹŵƵŵźŤƀĭ ƽƶƿŚěšŚƤǀƤŰţƭŚŬƳřƶƬŘƀƯƲǀưƷìƹí ŢǀƫŚƘƟƹŵřŶƘţ ƽƶƴǀƯŻŹŵ ƽŵŚƿŻšŚƘƫŚƐƯŶƿŚưƳƾ Ư ƽŹƹźƋ 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27 źĪƄţƹźƿŶƤţ ƭƺºƬƗƵŚĮƄºƳřŵƾƄºƷƹĦěƭźºŤŰƯŢƳƹŚƘƯŻřƶƬǀſƹƲƿřƶŝ żƿƺºŬţżºǀƳƹçëƹçìŵźºŝƾ ºƯLJŚºŝřŹPTZŻřƾƃŚƳŪƴƄţ ŢºǀŞŨţřŹƾƿŚƴºƃƹŹƹƾĪƿŹŚºţƽŚƷƵŹƹŵŹŵƵŶƃƩŚưƗřƲƯżƯ çíŶƿŚưƳƾ Ư ƾţŚºƤǀƤŰţƽƶºūŵƺŝƲǀƯŚţƹŜƿƺƈţŢƸūƶŝƱŚŬƳŻƾĪƃżě ƽźǀĭƶŬ ǀŤƳ ƂƿřżºƟřƮƛźºǀƬƗƶºĩŶºƷŵƾ ºƯƱŚƄƳƢǀƤŰţƲƿř ƽŚƷƵŵřŵ ŵŵźĭƾ ƯƽŹřżĭŽŚĜſ ƱŚƃŶƴưƃŻŹř ŶƃŹ ƽƶǀƫƹřƱřŹƹŵƹŶƳřƶŤƟŚ ƿ ƁŹƹźě ƾĪƿŹŚţŹŵƶĩ ƾţŚƳřƺǀů ƽƵŹƹŚƄºƯƽřźºŝŹƺºĜƷŵźºŤĩŵƽŚºƣōśŚƴūŻřżǀƳƹŭźƏƲƿř ŹŵŹƺƳŻřŢǀƯƹźŰƯƎſƺţƾƿŚƴǀŝźƄƣŹŵƾƿřŻƕźƇŵřŶƘŤſř therapy References + against intractable epilepsy. 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Epilepsy Res. 2008; 82: 66-71. Ghahremani MH, Dehpour clonic seizure Downloaded from zums.ac.ir at 5:23 IRST on Saturday March 4th 2017 K, ÕÖŹŚƸŝÔÍƽƵŹŚưƃ ÎÕƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ 30 ƱřŹŚƨưƷƹƾƳŚųŪƴĭƲǀƸƯźŤƧŵ Effects of Dark Rearing on Clonic Seizure Threshold and Pentyleneterazol Induced Epileptiform Activity in Mice Ganjkhani M1, Moradi K2, Ramezani S2, Mirzamohammadi F2, Fallah A2 1 Downloaded from zums.ac.ir at 5:23 IRST on Saturday March 4th 2017 Dept. of Physiology and Pharmacology, Faculty of Medicine, Zanjan University of Medicine, Sciences, Zanjan, Iran. 2 Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Corresponding Author: Ganjkhani M, Dept. of Physiology and Pharmacology, Faculty of Medicine, Zanjan University of Medicine, Sciences, Zanjan, Iran. E-mail: [email protected] Received: 10 Sep 2009 Accepted: 14 Dec 2009 Background and Objective: Epileptic seizures are generally considered as complex and abnormal hyperexcitable phenomena in the brain. Probable changing of excitability in visual cortex by dark rearing (DR) might lead to clonic seizure. In this study the possible effect of dark rearing on Pentylenetetrazol (PTZ) - induced generalized clonic seizure was studied. Materials and Methods: To assess the generalized clonic seizure (GCS) threshold and incidence and latency of GCS, 0.5% Pentylenetetrazol was administrated intravenously and 80 mg/kg subcutaneously to the control and dark reared animals. Results: Our results showed that generalized clonic seizure threshold in DR group was not changed but occurring of GCS in DR animals was significantly lower and its latency was higher than the control animals. The tonic – clonic seizure was not different between the two groups. Conclusion: In spite of increasing seizure susceptibility in visual cortex by light deprivation, a kind of protection was observed in dark reared animals. Further studies seem to be necessary to elucidate the role of other factors such as melatonin. Key words: Clonic seizure, Dark rearing, Pentylenetetrazol ÕÖŹŚƸŝÔÍƽƵŹŚưƃ ÎÕƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ
