HACCP-based food defense systems
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HACCP-based food defense systems
Zarz¹dzanie i Finanse Journal of Management and Finance Vol. 13, No. 2/2015 Ma³gorzata Z. Wiœniewska* Ma³gorzata Z. Wiœniewska HACCP-based food defense systems HACCP-based food defense systems Introduction The increasing complexity of food and feed production systems, the development of food processing technologies, the changes in the consumer needs and in the way of living and consumption, the introduction of novel foods and application of new food, as well as a food chain elongation may lead to new or unforeseen (emerging) risks for food safety. Not without significance is increased globalisation of trade, people migration, social inequalities, and turbulent political and social situation. All these factors may have a negative impact on human and animal safety, on health, environment and economy. From the perspective of Europe this can be proved by the PERIAPT report, prepared by VWA (Voedsel en Waren Autoriteit) – Food and Consumer Product Safety Authority in Hague, that additionally shows that presently known risks may re-occur and increase in frequency, due to the expansion of the European internal market, altered human habits or changes in conditions and methods of food production [Noteborn, Ooms, 2005, p. 4]. Moreover, during the last few decades, the media, government leaders, scholars and national security analysts have all called attention to the potential threat presented by terrorism as a means for political instability. It is nothing new that food became a weapon in the hands of terrorists. These issues are of great general concern. Nowadays, according to the WHO – World Health Organization, responsible governments, private companies, farmers, cannot ignore the possibility that terrorists, criminals and other antisocial groups may target the safety of food supply [WHO, 2008, p. 3]. Deliberate contamination of food and food chain, the food terrorism, as a real danger, becomes a subject of care for many countries and different institutions worldwide. According to WHO food terrorism can be defined as the act of threat of deliberate contamination of food for human consumption with chemical, biological or radio-nuclear agents for the purpose of causing injury or death to civilian populations and/or disrupting * Assoc. Prof., Ph.D. Hab., Unit of Quality and Environmental Management, Department of Enterprises Economics, Faculty of Management, University of Gdañsk, Armii Krajowej 101, 81-824 Sopot, [email protected] 106 Ma³gorzata Z. Wiœniewska social, economic or political stability [WHO, 2008, p. 4]. What is interesting, as specialists assume, in the same time, there are some common week points in today’s food safety supervision, like, i.a. [Emerging Risks..., 2005, p. 10]: – too much trust in existing assessment systems and protection measures, – neglecting open transparent regulatory procedures, – downplaying insider threats and consumer perception, – underestimating interdependencies and complexities of food production systems, – underestimating the ‘enforcement power’ of labelling and impact of incremental changes, – adopting a too reactive approach to risk management, – bypassing a two-way communication and exchange of information between all stakeholders, – less weight to criteria such as ethics and cultural aspects as compared to technical issues, – ignoring human factor and employees behaviour, Underestimating the possibility of malicious contamination. Considering the fact that the terrorists or other criminals rely on a lack of preparedness [Olson, 2012, pp. 1–8] and that the weakest points are usually the most vulnerable for negative, deliberate activity, it is required to implement the methods to protect against a potential or real attack. These proactive methods, based on the risk assessment, prepared in accordance with the best practices in the world, as proposed by the most experienced bodies and specialists, and implemented by food producers seem to be the best solutions in the times of new threats, arising from the unstable social, economical and political situation. What’s more, the implementation of such methods by the manufacturer, food supplier, is increasingly accented by food retailers, and, if evidenced in documents, treated as a ticket on the shelf in the supermarket. Currently the most recommended proactive methods for food defense are CARVER+Shock, HACCDP and TACCP. The first one has been already described by the author of the article [Wiœniewska, 2008, pp. 301–307], therefore the aim of the paper is to present, to analyze and then, to compare the last of two indicated, which respectively, are a kind of an extension, and of the modification of HACCP system. The research problem is to answer the question: What are the main differences and similarities between HACCDP, HACCP-based food defense systems 107 TACCP and HACCP? To resolve the problem the literature analysis, the official documents and specifications review and analysis were used as the research methods, as well as the methods of synthesis and conclusion. The first stage of the research plan is to recognize the character of HACCDP method versus HACCP system, the second stage of the research is to recognize the specificity of TACCP versus HACCP, the third stage of the research is to compare HACCDP with TACCP and based on that – to find out the main differences and similarities between those three approaches. 1. HACCDP as the extension of HACCP system Since years HACCP system has been proven effective as a food safety measure, referring to accidental hazards. It is a safety method that identifies and monitors hazards associated with food production before they happen. It is the cornerstone of many businesses’ food safety plans, and, according to European food law, is obligatory to be implemented by food business operators. According to Article 5 of Regulation (EC) No 852/2004 of the European Parliament and of the Council on the hygiene of foodstuffs requires food business operators to put in place, implement and maintain a permanent procedure based on Hazard Analysis and Critical Control Point (HACCP) principles. HACCP is a preventive tool for the production of safe food products and is based on technical and scientific principles applicable to every step of the food production chain, from farm to table. HACCP was developed by Pillsbury Company, after a request from the National Aeronautics and Space Administration in the 1960s, to ensure the safety of foods used in the American space program. It has changed and developed over the years. In 1991, the National Advisory Committee on Microbiological Criteria for Foods published a report determining the basic principles of the system as it is known today. After that it has been included, as the recommended system, in Codex Alimentarius, currently in the form of document CAC/RCP 1-1996, rev. 4-2003. As WHO convinces, the concepts and principles of HACCP commonly used for food safety risk assessment are also useful for addressing food defense concerns [Short summary..., 2007, pp. 1–7]. In other hand, according to different food safety specialists, like P. Takhistov and C. Bryant [Takhistov, Bryant, 2006, pp. 34–43], the tools used for food safety are not designed for food defense, and are not addressed to intentional, malicious 108 Ma³gorzata Z. Wiœniewska contamination. HACCP principles, as shows PAS 96:2014, have not been routinely used to detect or mitigate deliberate attacks on a system or process. Such attacks may include deliberate contamination or fraud. Deliberate acts may have food safety implications but can harm organizations in other ways, such as damaging business reputation or extorting money [PAS 96:2014, 2014, p. iii]. Food defense therefore, at minimum, requires the HACCP system to be extended or modified with regard to the new threats and their consequences. Having above in mind it seems to be interesting to present the modified version of HACCP in the form of HACCDP, described by Ch. Yoe and J.G. Schwartz [Yoe, Schwartz, 2010], food safety specialists from Maryland University in United States. HACCDP is the synthesis of a HACCP and covers the vulnerability assessment aspects, where vulnerability can be defined as ease of an attack at the point, place of the food processing cycle. HACCDP, Hazard Analysis Critical Control and Defense Points, is proposed as an extension of HACCP. It is recommended to be implemented rather in small or medium food companies than in bigger entities, where system CARVER+Shock is useful as a more comprehensive. HACCDP implementation stages are similar to those connected with HACCP, as it is presented in the table 1. Table 1. HACCDP and its steps No. HACCDP implementation steps The reference to HACCP system and to food defense plan 1 HACCP preliminary step 1 Assemble the HACCP team. 2 HACCP preliminary step 2 Describe the product. 3 HACCP preliminary step 3 Identify intended use. 4 HACCP preliminary step 4 Construct a flow diagram. 5 HACCP preliminary step 5 Conduct and on-site review of the flow diagram. 6 HACCP principle 1 Conduct a hazard analysis. 7 HACCP principle 2 Determine the CCPs. 8 HACCP principle 3 Establish critical limits. 9 HACCP principle 4 Establish monitoring procedures. 10 HACCP principle 5 Establish corrective actions. 11 HACCP principle 6 Establish verification procedures. HACCP-based food defense systems No. HACCDP implementation steps 109 The reference to HACCP system and to food defense plan 12 HACCP principle 7 Establish record-keeping and documentation procedures. 13 Food Defense Plan Determine CDPs in your process. 14 Food Defense Plan Devise food defense mitigations. 15 Food Defense Plan Implement, test, assess and maintain the defense mitigations. Explanation: CCP – Critical Control Point; CDP – Critical Defense Point Source: Own elaboration based on: [Yoe, Schwartz, 2010]. As can be seen, similarly to HACCP system, the core element of HACCDP is food defense plan. It can be defined as the plan used to reduce the risk of intentional contamination [FSIS Directive, 2011, p. 2]. The USDA’s Food Safety and Inspection Service defines a food defense plan as the document that sets out control measures developed by an establishment to prevent intentional adulteration of product. A food defense plan should be developed, written, implemented, tested, assessed, and maintained if it is to be functional [USDA, 2006], what is additionally presented in the table 2. Table 2. Food defense plan preparation, as the element of HACCDP Steps in food defense plan development Description Appoint Food Defense Coordinator The coordinator will lead the team in developing, implementing and maintaining HACCDP plan Develop the Plan The plan should include the following elements: process vulnerability, facility security, supply chain integrity, emergency response, like recall, disposal, recovery and communication Implement the Plan The plan is implemented when the defense measures identified are in place and being used as intended. Implementation steps will include all required approvals of the defense measures, budgeting for the measures, installing the measures and training personnel in the proper use and execution of the measures. 110 Steps in food defense plan development Ma³gorzata Z. Wiœniewska Description Test the Plan Plans can be tested in different ways. Simulations, drills, tabletop exercises, mock incidents and recalls, post-event evaluation and lessons learned, evacuation procedures and continuity of operations plans may be used. Assess the Plan The plan must be kept up to date and assesses on a regular basis. Employee turnover or changes in suppliers, the production process, contracted services and production lines require reviewing, updating and revising the plan. Occasionally, new defense measures may be added to the food defense plan. Maintain the Plan Maintenance activities may include purchasing new or replacement materials or equipment designed for food defense, making repairs or (re)training employees. Source: Own elaboration based on: [Yoe, Schwartz, 2010]. As can be seen HACCDP is a kind of an overlay of the HACCP system. The similarities between the systems which can be observed are very clear, what provides an opportunity to build up a successive approach against intentional contamination. However there is one condition of the success – the ability to differentiate CCPs from CDPs and to identify the consequences of the attack, which are more severe and more difficult to predict than while assessing the probability of accidental contamination. 2. TACCP as the modification of HACCP system TACCP (Threat Analysis and Critical Control Point) system had been presented and described for the first time in 2008 in Publicly Available Specification (PAS). The specification was developed by the Centre for the Protection of National Infrastructure (CPNI) in collaboration with The British Standards Institution (BSI). This original edition made use of preventative strategies within the World Health Organisation guidance on the “Terrorist Threat to Food”, mentioned before in the paper. The revised edition of PAS 96 has been published in 2010 and next, in 2014. The purpose of TACCP is to enable proportionate control procedures to be implemented so as to reduce the likelihood (chance) of malicious attack and to reduce the consequences (impact) of an attack. It is worth not- HACCP-based food defense systems 111 ing that the scope of the 2014 version is broader than the scope of the specification of PAS:2010. PAS:2010 provided guidance to food businesses on approaches to the protection of their business from all forms of malicious attack including ideologically motivated attack and to procedures to mitigate and minimize the impact of such an attack, whereas PAS 2014 provides guidance on the avoidance and mitigation of threats to food and food supply, additionally including those referring to EMA – Economically Motivated Adulteration (EMA) – so-called food fraud. According to PAS:2014, food fraud is committed when food is deliberately placed on the market, for financial gain, with the intention of deceiving the consumer, and can be understood as [PAS:2014, 2014, p. 1]: – the sale of food which is unfit and potentially harmful, such as: recycling of animal by-products back into the food chain, packing and selling of beef and poultry with an unknown origin, knowingly selling goods which are past their “use by” date, – the deliberate misdescription of food, such as: products substituted with a cheaper alternative, for example, farmed salmon sold as wild, and Basmati rice adulterated with cheaper varieties, making false statements about the source of ingredients, i.e. their geographic, plant or animal origin. Food fraud may also involve the sale of meat from animals that have been stolen and/or illegally slaughtered, as well as wild game animals like deer that may have been poached [PAS:2014, 2014, p. 2]. Threat Assessment Critical Control Point is the systematic management of risk through the evaluation of threats, identification of vulnerabilities, and implementation of controls to materials and products, purchasing, processes, premises, distribution networks and business systems by a knowledgeable and trusted team with the authority to implement changes to procedures, whereas the threat is defined as something that can cause loss or harm which arises from the ill-intent of people [PAS:2014, 2014, p. 3]. TACCP, according to PAS 96:2014 aims, i.a., to reduce the likelihood (chance) of a deliberate attack, to reduce the consequences (impact) of an attack and to protect organizational reputation. It helps to reassure customers, press and the public that proportionate steps are in place to protect food. It also satisfies international expectations and support the work of trading partners and demonstrates that reasonable precautions are taken and due diligence is exercised in protecting food. It is helpful 112 Ma³gorzata Z. Wiœniewska in identifying specific threats to the company’s business, in assessing the likelihood of an attack by considering the motivation of the prospective attacker, the vulnerability of the process, the opportunity and the capability they have of carrying out the attack. The company, while implementing TACCP system, has the opportunity to assess the potential impact by considering the consequences of a successful attack, to judge the priority to be given to different threats by comparing their likelihood and impact. What is important, TACCP cannot stop individuals or organizations claiming that they have contaminated food, but it can help judge whether that claim is likely to be true. Any such claim, if judged to be credible, and any actual incident should be treated as a crisis [PAS:2014, 2014, p. 9]. In total TACCP system implementation is divided into 16 steps, what is presented in the table 3. Table 3. TACCP implementation steps No. TACCP implementation steps Description 1 Form TACCP system TACCP could include individuals with the following expertise: security, human resources, food technology, process engineering, production and operations, purchasing and supply, distribution, communications, commercial/marketing. 2 Assess new information There is a need to evaluate all new information which has come to its attention. 3 Identify and assess threats to organization There is a need to identify individuals and/or groups which may be a threat to the organization and assess their motivation, capability and determination. 4 Identify and assess threats to operation There is a need to identify individuals and/or groups which may be a threat to the specific operation (e.g. premises, factory, and site). 5 Select product There is a need to select a product which is representative of a particular process. 6 Identify and assess threats to product There is a need to identify individuals and/or groups that may want to target the specific product. HACCP-based food defense systems No. TACCP implementation steps 113 Description 7 Devise flow chart There is a need to draw a process flow chart for of product supply chain the product from, but not limited by, ‘farm to fork’ including, for example, domestic preparation. The whole flowchart should be visible at one time. Particular attention should be paid to less transparent parts of the supply chain which might merit a subsidiary chart. 8 Identify key staff and vulnerable points From an examination of each step of the process there is a need to identify the vulnerable points where an attacker might hope for success and the people who would have access. 9 Consider impact of threats identified There is a need to identify possible threats appropriate to the product at each step and assess the impact that the process may have in mitigating the threats. 10 Identify which supply points are most critical There is a need to select the points in the process where the threat would have the most effect, and where they might best be detected. 11 Determine if control procedures will detect the threat There is a need to assess the likelihood of routine control procedures detecting such a threat. 12 Likehood versus impact – identify priority There is a need to score the likelihood of the threat happening, score the impact it would have, and chart the results to show the priority it should be given, and revise if this risk assessment seems wrong. 13 Identify who could carry it out? where the priority is high, identify who has unsupervised access to the product or process and whether they are trustworthy, and if that trust can be justified. 14 Decide and implement necessary controls There is a need to identify, record confidentially, agree and implement proportionate preventative action (critical controls). The TACCP team should have confidential reporting and recording procedure that allows management action on decisions but does not expose weaknesses to those without a need to know. 15 Review and revise There is a need to determine the review and revise arrangements for the TACCP evaluation. 114 No. Ma³gorzata Z. Wiœniewska TACCP implementation steps 16 Monitor horizon scans and emerging risks Description There is a need to maintain a routine watch of official and industry publications which give an early warning of changes that may become new threats or change the priority of existing threats, including more local issues as they develop. Source: Own elaboration based on: [PAS:2014, 2014, pp. 10–11]. 3. HACCDP versus TACCP HACCDP and TACCP systems, as HACCP-based have several aspects very close to HACCP system. What’s more there are also many areas which evidently make those two systems very similar to each other, however the systems are not identical. First of all HACCDP had been presented by scientists, food specialist, who described it in the form of the article, whereas TACCP system is the result of the long term cooperation of different organizations that were involved in the development of PAS:2008, PAS:2010 and then PAS:2014. Among them are, i.a.: Agrico UK Limited, Bakkavor, Cargill, Department for Environment, Food & Rural Affairs, Food and Drink Federation (FDF), Food Standards Agency (FSA), GIST Limited, Global Food Security Programme, Heineken UK, Hilton Food Group plc, J Sainsbury plc, Leatherhead Food Research, McDonald’s Europe, Raspberry Blonde, SSAFE and Tesco plc. Next, for the fact that TACCP is presented within the framework of Publically Available Specification under the auspices of BSI, it has more formal character, as well as more standardized. It is worth to say that PAS is not to be regarded as a British Standard. It will be withdrawn upon publication of its content in, or as, a British Standard. Nevertheless both approaches, as proposed by their authors, are, so far, voluntary, however recommended to be applied by different food processors. What is interesting, HACCDP is better to be used for smaller and medium organizations, whereas TACCP can be implemented by all food processors, regardless of the size. As it was mentioned before, HACCDP is an extension of HACCP system, and TACCP is rather a kind of HACCP modification, including the specificity of food defense. It can be observed in the meaning and in the scopes of the subsequent implementation steps of TACCP, where, i.a. HACCP principles have been transformed into TACCP principles. Another difference is the scope of the threats taken into account. 115 HACCP-based food defense systems HACCDP systems covers the threats connected with food terrorism, including food sabotage, whereas TACCP system distinguishes several types of threats, connected with EMA (Economically Motivated Adulteration), with malicious contamination (in the sense of food terrorism and sabotage), extortion, espionage, counterfeiting and cyber crime. Very similar is the structure of the both approaches. They are based on seven HACCP principles and on twelve implementation steps, as indicated originally in Codex Alimentarius for HACCP purposes. As can be observed, in both systems very important is food defense plan, however the information about that aspect in the context of HACCDP is rather simplified and general, unlike TACCP system, in which the plan has been described in great details. In very detailed form are also presented the rules of the risk scoring matrix applicable in TACCP system implementation, where the threat is categorized into five groups connected with the particular risks, like: very high risk, high risk, moderate risk, low risk and negligible risk, what depends on the scoring system addressed to likelihood (very high chance, high chance, some chance, may happen chance, unlikely to happen chance) and impact of the particular threat (catastrophic, major, significant, some, minor). In TACCP system, what can’t be observed in HACCDP described by Ch. Yoe and J.G. Schwartz [Yoe, Schwartz, 2010], very helpful is the presentation of the critical controls, which can be recognized as the prerequisites conditions of TACCP. These conditions refer, i.a. to: access to premises, to vehicles, to access to people, to screening of visitors, to detecting tempering, to pre-employment checks, to on-going personnel security, as well as to the end of contract agreements, treated as the possible, vulnerable places, points of the threats for the company. To sum up, the main differences and similarities between the described systems are illustrated in the table 4. Table 4. HACCDP, TACCP and HACCP – comparison Aspect Publication body HACCDP Scientists, food safety specialists TACCP BSI HACCP Codex Alimentarius Commission FAO/WHO 116 Ma³gorzata Z. Wiœniewska Aspect HACCDP TACCP HACCP Character Informal, not standardized Formal, standardized Formal, standardized (mainly as published, i.e. in the form of ISO 22000) Implementation Voluntary Voluntary Obligatory in most countries Interested party/addressee Small and medium food companies All food processors All food processors HACCDP/TACCP Extension versus HACCP Modification – Object of the interest Threat Threat Hazard Scope Intentional contamination, without specifying types of threat; focused on food terrorism, including sabotage Intentional contamination, with specifying types of threat into EMA, malicious contamination, extortion, espionage, counterfeiting, cyber crime Accidental Structure HACCP-based HACCP-based 7 principles Steps 15 steps in total; of the implementa Codex tion Alimentarius implementation steps-based 16 steps in total; Codex Alimentarius implementation steps-based 12 steps in total, according to Codex Alimentarius Defense plan General HACCP-based Precise HACCP-based HACCP plan Examples, case studies General Precise General in the form of General Principles of Food Hygiene 117 HACCP-based food defense systems Aspect HACCDP TACCP HACCP Risk scoring matrix Not included Included Included (Example: Guidelines for Risk Analysis of Foodborne Antimicrobial Resistance CAC/GL 77- 2011) Critical controls Not included Included Included in the form of General Principles of Food Hygiene Source: Own elaboration. Conclusion As it has been proved and described in the paper, deliberate contamination of food requires new methods and new approaches to be implemented by food processors. All presented and mentioned systems (including CARVER+Shock) are HACCP-based and by that fact they seem to be familiar for producers and ease to be integrated with existing practices to protect the safety of the food product. Of course, one can conclude that they involve the specific aspects connected with food defense area, particularly, a requirement to develope a food defense plan, that may be prepared with regard to the assumption of HACCP plan, and to assess the risks connected with a particular threat. Depending on the current experience, on the personnel knowledge, on the identified, potential or real, and observed hazards and threats, on the size of the company, food producer can choose the best solution for the company, to satisfy the needs of individual and of the institutional customers in terms of food defense, which can be defined as putting measures in place that reduce the chances of the food supply from becoming intentionally contaminated using a variety of chemicals, biological agents or other harmful substances by people. The food producers has to be conscious that these agents could include materials that are not naturally-occurring or substances not routinely tested for in food products. Very important is to be aware that a terrorist’s goal might be to kill people, disrupt the economy, or ruin the business and its reputation. What is crucial, intentional acts generally occur infrequently and can be difficult to detect, and are very hard to pre- 118 Ma³gorzata Z. Wiœniewska dict. Therefore, there is not only a need to implement the methods, like those described in the article, but also to encourage to exchange the experience among the companies, to compare the best practices, to allow food processors to be more and better prepared in case of the attack. In turbulent times it seems to be an obligation. References 1. Emerging Risks Identification in Food and Feed for Human Health (2005), VWA – Food and Consumer Product Safety Authority, Directorate of Research and Risk Assessment, The Hague. 2. FSIS Directive, 5420.1, Revision 7, 6/27/11, http://www.fsis.usda.gov/ wps/wcm/connect/09d861e7-affa-476d-ae32-5dfde9e23523/5420.1.pdf? MOD=AJPERES, accessed 10.10.2014. 3. Noteborn H.P.J.M., Ooms B.W. (ed.) (2005), Emerging Risks Identification in Food and Feed for Human Health, VWA – Food and Consumer Product Safety Authority, Directorate of Research and Risk Assessment, The Hague. 4. Olson D. (2012), Agroterrorism Threats to America’s Economy and Food Supply, “FBI Law Enforcement Bulletin” February. 5. Short summary on food defense (2007), “IUFoST Scientific Information Bulletin” September, http://www.foodlawment.hu/downloads/iuf_ sib_food_defense.pdf, accessed 10.10.2014. 6. Takhistov P., Bryant C. (2006), Protecting the Food Supply, “Food Technology” No. 60(7). 7. USDA (2006), PBIS Profile Extension Instructions on Food Defense Plans for Meat and Poultry Establishments, Food Safety Inspection Service, 20 April 2006. www.fsis.usda.gov/OPPDE/rdad/FSISNotices/28-06.pdf, accessed 10.10.2014. 8. WHO (2008), Terrorist Threats to Food: Guidance for Establishing and Strengthening Prevention and Response Systems. Food Safety Issues Series, Geneva. 9. Wiœniewska M. (2008), HACCP to za ma³o, in: M. Wiœniewska, E. Malinowska (ed.), Jakoœæ, bezpieczeñstwo, ekologia w sektorze rolno-spo¿ywczym. Kierunki rozwoju, FRUG, Sopot. 10. Yoe Ch., Schwartz J.G. (2010), Incorporating Defense into HACCP, “Food Safety Magazine” August/September, http://www.foodsafetymagazi ne.com/magazine-archive1/augustseptember-2010/incorporating-defense-into-haccp, accessed 10.10.2014. HACCP-based food defense systems 119 HACCP-based food defense systems (Summary) The aim of this paper is to present and analyze systems for food defense, based on the assumptions of the HACCP system, and then to compare them to each other. In the first part HACCDP has been presented and it the second – TACCP system. During the comparative analysis the interest has been focused on factors such as: the body publishing the assumptions of the system, the character of the system, obligatory issues, the addressee of the system, the type of system, the object of interest, scope, structure of the system, the steps of implementation, food defense plan, relevant examples, a reference to the risk assessment matrix, and control areas. The similarities and differences between the systems were also highlighted. In conclusion, it was pointed out that the choice of the presented approaches depends, i.a. on the previous experience of the company, on its size and on the needs of customers. It was stated that the cooperation between the food companies is required in the area of knowledge exchange and comparison of the best practices for food defense. Keywords food defense, intentional contamination, HACCDP, TACCP, HACCP systems