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POLISH JOURNAL of PHARMACOLOGY VOL. 54 / 2002 / NUMBER 1 CONTENTS Chronic treatments with haloperidol and clozapine alter the level of NMDA-R1 mRNA in the rat brain: an in situ hybridization study. Krystyna Ossowska, Ma³gorzata Pietraszek, Jadwiga Wardas, Marta Dziedzicka-Wasylewska, Dorota Nowicka, Stanis³aw Wolfarth . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxia. Agnieszka Nadlewska, Halina Car, Robert Oksztel, Konstanty Wiœniewski . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies. Jerzy Michaluk, Anna Krygowska-Wajs, Beata Karolewicz, Lucyna Antkiewicz-Michaluk 19 Role of nitric oxide in benzodiazepines-induced antinociception in mice. Sylwia Talarek, Sylwia Fidecka . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Effects of tibolone on the development of osteopenia induced by ovariectomy in rats. Maria Pytlik. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 In vitro cytostatic activity of 8-substituted and tricyclic analogues of acyclovir. Bogus³aw H³adoñ, Tomasz Goœliñski, Halina Laskowska, Daniel Baranowski, Tomasz Ostrowski, Joanna Zeidler, Piotr Ruszkowski, Bo¿enna Golankiewicz. . . . . . . 45 Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives. Ahmed O. Maslat, Mahmud Abussaud, Hasan Tashtoush, Mahmoud AL-Talib . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 SHORT COMMUNICATIONS Prolonged treatment with glucocorticoid dexamethasone suppresses melatonin production by the chick pineal gland and retina. Jolanta B. Zawilska, Magdalena Sadowska . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase. Sayit Altikat, Mehmet Çiftçi, Mehmet E. Büyükokuroðlu. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 PRELIMINARY COMMUNICATION Inhibition of arachidonic acid cascade attenuates the induction of c-FOS proteins by DOI, 5-HT2A/2C receptor agonist, in the rat cortex. Marzena Maækowiak, Anna Czyrak, Krzysztof Wêdzony. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Abstracts of Sixth Conference on PROGRESS IN ETIOPATHOGENESIS OF SEIZURES . . 77 Note to contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Index 369047