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VOL. 1 Review Neuronal autophagy in cerebral ischemia 129 a potential target for neuroprotective strategies? 140 Nirav Dhanesha, Amit Joharapurkar, Gaurang Shah, Malinka, Katarzyna Cielik-Boczula, Joanna Petrus, Vipin Dhote, Samadhan Kshirsagar, Rajesh Bahekar, Mukul Jain Review Whats the role of topiramate in the man- 150 diated calcium signaling is blunted in long lasting disorders? Antonio Siniscalchi, Luca Gallelli, Chiara type 1 diabetes mellitus. Review Animal models of acute renal failure. Lipiñska, Anna Kucharska, Beata Michalska, Maria W¹sik 157 Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line. Patrycja Kwieciñska, Erik Anxiogenic effect of CCK8s in the ventral hippo- Taubøll, Ewa £. Gregoraszczuk of GABAA receptors. Akbar Hajizadeh Moghaddam, 166 Beata Starek-wiechowicz, Katarzyna Miranowicz- Anxiolytic-like effect of losartan injected into amygdala of the acutely stressed rats. Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats. Robabeh Sadat Hosseini, Ali Roohbakhsh Dzier¿awska, Wies³aw Szymczak, Bogus³awa Luis H. Llano Budziszewska, Andrzej Starek López, Fernando Caif, Sebastián García, Miriam 179 Fraile, Adriana I. Landa, Gustavo Baiardi, José V. Modulation of Th1/Th2 cytokine production by selective and nonselective phosphodiesterase inhibi- Lafuente, Jan J. Braszko, Claudia Bregonzio, Pascual tors administered to mice. Marianna Szczypka, A. Gargiulo Sebastian Ploch, Bo¿ena Obmiñska-Mrukowicz Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive 185 Krzysztof Safranow, Daniel Kotrych, Andrzej Repeated administration of caffeine induces either depending on the environmental context. Roberta ESR1 and ESR2 gene polymorphisms on Andrzej Pawlik, Violetta Dziedziejko, Mateusz Kurzawski, Zehra Batool, Tahira Perveen, Darakhshan J. Haleem sensitization or tolerance of locomotor stimulation Effect of rheumatoid arthritis treatment with methotrexate. like behavior in rats. Fizza Naqvi, Saida Haider, Bohatyrewicz 191 Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental Zancheta, Ana P.M. Possi, Cleopatra S. Planeta, models. Danish Mahmood, Razia Khanam, Krishna Marcelo T. Marin 78 Urszula Demkow, Pawe³ Winklewski, Olga Ciepiela, Katarzyna Popko, Anna campus of rats: possible involvement 70 Modulatory effect of insulin on T cell receptor me- agement of patients with hyperkinetic movement Dhawan 64 Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect. Singh Jaggi, Nirmal Singh, Kuldeep Grover, Ravi 54 Fructose-fed streptozotocin-injected rat: an alter- Kazimierz G¹siorowski, Piotr wi¹tek, Wies³aw Amrit Pal Singh, Arunachalam Muthuraman, Amteshwar 45 2012 their biological activity. Agata Jaszczyszyn, Giofrè, Giovambattista De Sarro 31 1 Md. Shahidul Islam Review Chemical structure of phenothiazines and Bogus³awa Czarnik-Matusewicz 24 NUMBER native model for type 2 diabetes. Rachel D. Wilson, Bo¿ena Gabryel, Alicja Kost, Daniela Kasprowska 16 64 Kolappa Pillai, Mohd Akhtar Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line. Wanda Dyr, Ewa Taracha 84 SHORT COMMUNICATIONS Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients 205 sildenafil, on antidepressant-like activity of magne- with pain. Wojciech Leppert, Przemys³aw Miko³ajczak, sium in the forced swim test in mice. Katarzyna Ewa Kamiñska, Micha³ Szulc 94 Soca³a, Dorota Nieoczym, Ewa Poleszak, Piotr Wla Central effect of crocin on penicillin-induced epileptiform activity in rats. Esmaeal Tamaddonfard, 212 lemic patients. Kazuhiko Kotani, Toshiyuki Yamada, Analgesic and anticonvulsant activity of new de- Michiaki Miyamoto, Shun Ishibashi, Nobuyuki Taniguchi, rivatives of 2-substituted 4-hydroxybutanamides in mice. Kinga Sa³at, Katarzyna Kulig, Robert Sa³at, Alejandro Gugliucci 217 Barbara Filipek, Barbara Malawska 113 New conjugates of muramyl dipeptide and normuramyl dipeptide linked to tuftsin and retro- Pharmacokinetics and pharmacodynamics of pro- tuftsin derivatives significantly influence their bio- pofol in patients undergoing abdominal aortic surgery. Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholestero- Nasrin Hamzeh Gooshchi, Sona Seiednejad-Yamchi 102 Influence of the phosphodiesterase type 5 inhibitor, logical activity. Krystyna Dzierzbicka, Anna Pawe³ Wiczling, Agnieszka Bienert, Pawe³ Wardowska, Ma³gorzata Rogalska, Piotr Trzonkowski Sobczyñski, Roma Hartmann-Sobczyñska, Krzysztof Bieda, Aleksandra Marcinkowska, Maria Malatyñska, Roman Kaliszan, Edmund Grzekowiak 123 Influence of 825 C>T polymorphism of G protein b3 227 Abstract of the Fourth Conference on PROGRESS IN EPILEPSY AND ANTIEPILEPTIC DRUGS GNB3) on hemodynamic response subunit gene ( during dobutamine stress echocardiography. Anna Bana, Edyta P³oñska, Barbara Larysz, Mateusz Kurzawski, Marek Drodzik 246 Note to Contributors