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CHEMICAL PROBES: EXPLORING AVENUES FOR PROTEIN INVESTIGATION
25-26 April, 2016 Łódź
MONDAY
10:30 - 12:00
Registration
12:00 – 12:15
Welcome
CHAIR
Christian Ducho
12:15 – 13:00
Epitope mapping as a probe for tracking autoimmunological diseases
Beata Kolesińska, Lodz University of Technology, Poland
13:00 – 13:25
TBA
Remigiusz Serwa, Imperial College of London, UK
13:25 – 13:40
Design and synthesis of novel probes for plant proteins
Daniel Krahn, Renier van der Hoorn, University of Oxford, U.K.
13:40 – 14:55
Lunch
CHAIR
14:55 – 15:20
Remigiusz Serwa
Highly Efficient Bioorthogonal Catalysis Reaction with Improved Biocompatibility for
Click Chemistry
Ozlem Dilek, Istanbul Kemerburgaz Universitesi
Substrate specificity profiling and its application in inhibitor and probe design
Steven Verhelst, University of Leuven, Belgium
Unnatural amino acids in design of proteases probes
Katarzyna Groborz, Marcin Drąg, Wrocław University of Technology, Poland
Hyper-reactive Cys profiling in plants
Kyoko Morimoto, Renier van der Hoorn, University of Oxford, U.K.
15:20 – 15:45
15:45 – 16:00
16:00 – 16:15
16:15 – 16:30
Coffee break
16:30 – 17:30
17:30 -
Future initiatives: for PIs only
Free evening
TUESDAY
CHAIR
9:10 – 9:35
9:35 – 10:00
10:00 – 10:15
10:15-10:30
Ozlem Dilek
Chemoproteomics-enabled discovery of cysteine-reactive inhibitors
Alexander Adibekian, University of Geneva, Switzerland
P2Y purinoceptors mediate phosphorothioate nucleotides-induced changes in
intracellular calcium as well as long-term effects
Maria Koziołkiewicz, Edyta Węgłowska, Marcin Szustak, Edyta GendaszewskaDarmach, Lodz University of Technology, Poland
Development of reagents for MS-based chemical proteomics using a modular approach
Jacob Hauser, Robin Bon, University of Leeds, UK
Synthesis of Ahp-cyclodepsipeptides as protease inhibitors
Steffen Köcher, Markus Kaiser, University of Duisburg-Essen, Germany
10:30 – 11:00
Coffee break
CHAIR
11:00 – 11:45
Artur Mucha
Development of inhibitors of the p53-MDM2/MDMX interaction
Tad Holak, Aleksandra Twarda, Jagiellonian University, Poland
Click chemistry in construction of electrochemically active probes
Agnieszka Olejniczak, Institute of Medical Biology of PAS, Poland
Chemical and Genetic Interrogation of Novel Antimalarial Targets
Edgar Deu, The Francis Crick Institute, UK
Phosphorus analogues of isothiocyanates – synthesis, biological activity and their
application as potential fluorescent probes
Łukasz Janczewski, Anna Gajda, Mateusz Psurski, Marta Świtalska, Joanna Wietrzyk,
Józef Oleksyszyn, Tadeusz Gajda, Lodz University of Technology, Wroclaw University
of Technology, Institute of Immunology and Experimental Therapy PAS, Poland
11:45 – 12:10
12:10 – 12:35
12:35 – 12:50
12:50 – 14:05
Lunch
CHAIR
14:05 – 14:30
15:35 – 15:40
Steven Verhelst
Proteomics enquiry of adaptation to proteasome inhibitors in leukemia
Bogdan Florea, University of Leiden, Netherlands
Covalent inhibitors of bacterial ureases
Łukasz Berlicki, Wrocław University of Technology, Poland
Target identification for bioactive small molecules
Markus Kaiser, University of Duisburg-Essen, Germany
Design and synthesis of potential phosphonocarboxylate inhibitors and probes for
RabGGTase
Łukasz Joachimiak, Michał Jakubczyk, Katarzyna Błażewska, Lodz University of
Technology, Poland
Closing remarks
15:40 – 16:00
16:00 19:00
Coffee break
Exploring Łódź
Final dinner at Gronowalski Restaurant
14:30 – 14:55
14:55 – 15:20
15:20 – 15:35