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ZAKŁAD ONKOLOGII MOLEKULARNEJ I TRANSLACYJNEJ
PUBLIKACJE PEŁNOTEKSTOWE
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Pracownia Badań Translacyjnych:
1. Kowalewska M, Bakula-Zalewska E, Chechlinska M, Goryca K, Nasierowska-Guttmejer A, Danska-Bidzinska A,
Bidzinski M. microRNAs in uterine sarcomas and mixed epithelial-mesenchymal uterine tumors: a
preliminary report. Tumour Biol. 2013;34:2153-60.
2. Bujko M., Kober P., Tysarowski A., Matyja E.., Mandat T., Bonicki W., Siedlecki JA.EGFR, PIK3CA, KRAS and
BRAF mutations in meningiomas. Oncol Lett. accepted 2013.10.02
3. Fabisiewicz A, Pacholewicz K,Paszkiewicz-Kozik E, Osowiecki M, Walewski J, Siedlecki JA. Polymorphism of
DNA repair and oxidative stress genes in B-cell lymphoma patients. Biomedical Reports 2013; 1: 51-155
4. Bielinska B, Gaj P, Kluska A, Nowakowska D, Balabas A, Dabrowska M, Niwinska A, Gruchota J, Zub R, Skasko
E, Steffen J, Ostrowski J, Siedlecki JA. Association of the BRCA1 promoter polymorphism rs11655505 with the
risk of familial breast and/or ovarian cancer. Fam Cancer. 2013;12:691-8.
5. Dewaele B, Przybyl J, Quattrone A, Finalet Ferreiro J, Vanspauwen V, Geerdens E, Gianfelici V, Kalender Z,
Wozniak A, Moerman P, Sciot R, Croce S, Amant F, Vandenberghe P, Cools J*, Debiec-Rychter M*.
Identification of a novel, recurrent MBTD1-CXorf67 fusion in low-grade endometrial stromal sarcoma. Int J
Cancer. 2013 [Epub ahead of print]
6. Lagarde P*, Przybyl J*, Brulard C, Pérot G, Pierron G, Delattre O, Sciot R, Wozniak A, Schöffski P, Terrier P,
Neuville A, Coindre JM, Italiano A, Orbach D, Debiec-Rychter M, Chibon F. Chromosome instability accounts
for reverse metastatic outcomes of pediatric and adult synovial sarcomas. J Clin Oncol. 2013;31:608-15.
7. Rutkowski P, Przybył J, Zdzienicki M. Extended Adjuvant Therapy with Imatinib in Patients with
Gastrointestinal Stromal Tumors: Recommendations for Patient Selection, Risk Assessment, and Molecular
Response Monitoring. Mol Diagn Ther. 2013;17:9-19.
8. Kowalik A, Kopczyński J, Wypiórkiewicz E, Góźdź S, Meżyk R, Siedlecki JA. Active transport of RB protein from
the nucleus to the cytoplasm as one of the development mechanisms of HER2-positive breast cancer. Pol J
Pathol., 2013; 64: 9-14.
9. Brzoska E, Kowalewska M, Markowska A, Kowalski K, Archacka K, Zimowska M, Grabowska I, Czerwińska AM,
Góra M, Stremińska W, Jańczyk-Ilach K, Ciemerych MA.The Sdf-1 (CXCL12) improves skeletal muscle
regeneration via the mobilization of Cxcr4 and CD34 expressing cells. Biol Cell. 2012;104:722-37
10. Rutkowski P, Bylina E, Klimczak A, Switaj T, Falkowski S, Kroc J, Lugowska I, Brzeskwiniewicz M, Melerowicz
W, Osuch C, Mierzejewska E, Wasielewski K, Woźniak A, Grzesiakowska U, Nowecki ZI, Siedlecki JA, Limon J.
The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST)
after imatinib failure - one institution study. BMC Cancer, 2012; 12: 223.
11. Przybyl J, Sciot R, Rutkowski P, Siedlecki JA, Vanspauwen V, Samson I, Debiec-Rychter M. Recurrent and
novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases. Tumour Biol.
2012;33:2245-53.
12. Rzepecka IK, Szafron L, Stys A, Bujko M, Plisiecka-Halasa J, Madry R, Osuch B, Markowska J, Bidzinski M,
Kupryjanczyk J. High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and
molecular associations.Cancer Genet. 2012 Mar;205:94-100
13. Kowalewska M, Radziszewski J, Goryca K, Bujko M, Oczko-Wojciechowska M, Jarzab M, Siedlecki JA and
Bidzinski M.Estimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the
assessment of marker gene expression in the lymph nodes. BMC Cancer.2012;12:223
14. Kowalewska M, Danska-Bidzinska A, Bakula-Zalewska E, Bidzinski M.Identification of suitable reference
genes for gene expression measurement in uterine sarcoma and carcinosarcoma tumors. Clin Biochem.
2012;45:368-71
ZAKŁAD ONKOLOGII MOLEKULARNEJ I TRANSLACYJNEJ
PUBLIKACJE PEŁNOTEKSTOWE
15. Przybyl J, Jurkowska M, Rutkowski P, Debiec-Rychter M, Siedlecki JA. Downstream and intermediate
interactions of synovial sarcoma-associated fusion oncoproteins and their implication for targeted therapy.
Sarcoma. 2012;2012:249219. Epub 2012 Mar 25.
16. Rutkowski P, Badalamenti G, La Paglia L, Przybyl J, Debiec-Rychter M. Chapter: “Gene Signatures in
Gastrointestinal Stromal Tumors”, Book Title: “Diagnostic, Prognostic, and Therapeutic Values of Gene
Signatures”; “Current Clinical Pathology” series edited by A. Russo, S. Iacobelli, and J. L. Iovanna. Springer
2012, p.35-50. ISBN: 978-1-61779-358-5.
17. Rutkowski P, Wozniak A, Dębiec-Rychter M, Kąkol M, Dziewirski W, Zdzienicki M, Ptaszynski K, Jurkowska M,
Limon J, Siedlecki JA. Clinical utility of the new American Joint Committee on Cancer staging system for
gastrointestinal stromal tumors: current overall survival after primary tumor resection. Cancer, 2011; 117:
4916-24.
18. Fabisiewicz A., Paszkiewicz-Kozik E., Osowiecki M., Walewski J, Siedlecki J.A. FcgRIIA and FcgRIIIA
polymorphisms do not influence survival and response to rituximab, cyclophosphamide, doxorubicin,
vincristine, and prednisone immunochemotherapy in patients with diffuse large B-celllymphoma, Leukemia
& Lymphoma 2011 ;52:1604-6
19. Kober P, Bujko M, Olędzki, J, Tysarowski A, Siedlecki JA."Methyl-CpG binding column-based identification of
nine genes hypermethylated in colorectal cancer" Mol Carcinog. 2011;50:846-56
20. Walidacja wybranych ośrodków zaangażowanych w diagnostykę molekularną chorób nowotworowych w
zakresie oznaczania mutacji w genie EGFR1. Tysarowski A, Kowalski D, Kowalczuk O. Onkol. Prakt. Klin. 2011;
7:138-145.
21. Chechlinska M, Kowalewska M, Brzoska-Wojtowicz E, Radziszewski J, Ptaszynski K, Rys J, Kaminska J, Nowak
R. Squamous cell carcinoma antigen 1 and 2 expression in cultured normal peripheral blood mononuclear
cells and in vulvar squamous cell carcinoma. Tumour Biol. 2010;31:559-67
22. Kowalewska M, Szkoda MT, Radziszewski J, Ptaszynski K, Bidzinski M, Siedlecki JA. The frequency of human
papillomavirus infection in Polish patients with vulvar squamous cell carcinoma. Int J Gynecol Cancer.
2010;20:434-7
23. Rutkowski P, Nowecki ZI, van Akkooi AC, Kulik J, Wanda M, Siedlecki JA, Eggermont AM, Ruka W.
Multimarker reverse transcriptase-polymerase chain reaction assay in lymphatic drainage and sentinel node
tumor burden. Ann Surg Oncol., 2010; 1 :3314-23.
24. Chechlinska M, Kowalewska M, Nowak R. Systemic inflammation as a confounding factor in cancer
biomarker discovery and validation. Nat Rev Cancer. 2010;10:2-3
25. M. Bujko, P. Kober, E. Matyja, P. Nauman, K. Dyttus-Cebulok, B. Czeremszynska, W. Bonicki, J. A. Siedlecki
“Prognostic value of IDH1 mutations identified with PCR-RFLP assay in glioblastoma patients” Mol Diagn
Ther. 2010 Jun 1;14:163-9
26. Radziszewski J, Kowalewska M, Jedrzejczak T, Kozlowicz-Gudzinska I, Nasierowska-Guttmejer A, Bidzinski M,
Siedlecki JA. The accuracy of the sentinel lymph node concept in early stage squamous cell vulvar carcinoma.
Gynecol Oncol. 2010;116:473-7
27. Kowalewska M, Nowak R, Chechlinska M. Implications of Cancer-Associated Systemic Inflammation for
Biomarker Studies. BBA-Rev Cancer 2010;1806:163-71.
28. Rutkowski P, Nowecki ZI, van Akkooi AC, Kulik J, Wanda M, Siedlecki JA, Eggermont AM, Ruka W.
Multimarker reverse transcriptase-polymerase chain reaction assay in lymphatic drainage and sentinel node
tumor burden. Ann Surg Oncol. 2010; 1:3314-23.
29. Ruka W, Rutkowski P, Szawłowski A, Nowecki Z, Debiec-Rychter M, Grzesiakowska U, Dziewirski W, Siedlecki
JA, Michej W. Surgical resection of residual disease in initially inoperable imatinibresistant/intolerant
gastrointestinal stromal tumor treated with sunitinib. Eur J Surg Oncol., 2009;35: 87-91.
ZAKŁAD ONKOLOGII MOLEKULARNEJ I TRANSLACYJNEJ
PUBLIKACJE PEŁNOTEKSTOWE
30. Maruszak A, Safranow K, Gustaw K, Kijanowska-Haładyna B, Jakubowska K, Olszewska M, Styczyńska M,
Berdyński M, Tysarowski A, Chlubek D, Siedlecki J, Barcikowska M, Zekanowski C. PIN1 gene variants in
Alzheimer's disease. BMC Med Genet. 2009; 10: 115-126.
31. Zielenkiewicz U, Kowalewska M, Kaczor C, Ceglowski P. In vivo interactions between toxin-antitoxin proteins
epsilon and zeta of streptococcal plasmid pSM19035 in Saccharomyces cerevisiae. J Bacteriol.
2009;191:3677-84
32. Paszkiewicz-Kozik E, Kulik J, Fabisiewicz A, Tysarowski A, Kraszewska E, Siedlecki JA, Walewski J. Presence of
t(14;18) positive cells in blood and bone marrow does not predict outcome in follicular lymphoma. Med
Oncol. 2009; 26:16–21.
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Pracownia Biochemii
1. Sarnowska EA, Rolicka AT, Bucior E, Cwiek P, Tohge T, Fernie AR, Jikumaru Y, Kamiya Y, Franzen R, Schmelzer
E, Porri A, Sacharowski S, Gratkowska DM, Zugaj DL, Taff A, Zalewska A, Archacki R, Davis SJ, Coupland G,
Koncz C, Jerzmanowski A, Sarnowski TJ. DELLA-Interacting SWI3C Core Subunit of Switch/Sucrose
Nonfermenting Chromatin Remodeling Complex Modulates Gibberellin Responses and Hormonal Cross Talk
in Arabidopsis. Plant Physiology 163: 305-317 SEP 2013
2. Archacki R, Buszewicz D, Sarnowski TJ, Sarnowska E, Rolicka AT, Tohge T, Fernie AR, Jikumaru Y, Kotlinski M,
Iwanicka-Nowicka R, Kalisiak K, Patryn J, Halibart-Puzio J, Kamiya Y, Davis SJ, Koblowska MK, Jerzmanowski
A. BRAHMA ATPase of the SWI/SNF chromatin remodeling complex acts as a positive regulator of gibberellinmediated responses in arabidopsis. PLoS One. 2013;8:e58588.
3. Sarnowska E, Balcerak A, Olszyna-Serementa M, Kotlarek D, Sarnowski TJ, Siedlecki JA. Postepy Hig Med
Dosw. AMP-activated protein kinase (AMPK) as therapeutic target. 2013 Aug 5;67:750-60. Polish.
4. Grzybowska EA, Zayat V, Konopiński R, Trębińska A, Szwarc M, Sarnowska E, Macech E, Korczyński J, Knapp A,
Siedlecki JA. HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing. FEBS J.
2013 Jan;280(1):256-72.
5. Grzybowska EA. Human intronless genes: Functional groups, associated diseases, evolution, and mRNA
processing in absence of splicing. Biochemical and Biophysical Research Communications, 424 (1): 1-6 . Jul
20 2012
6. Domagalska MA, Sarnowska E, Nagy F, Davis SJ. Genetic analyses of interactions among gibberellin, abscisic
acid, and brassinosteroids in the control of flowering time in Arabidopsis thaliana. PLoS One. 2010 Nov
17;5:e14012.
7. Trebinska A, Rembiszewska A, Ciosek K, Ptaszynski K, Rowinski S, Kupryjanczyk J, Siedlecki JA, Grzybowska
EA. HAX-1 overexpression, splicing and cellular localization in tumors. BMC Cancer. 2010 Mar 2;10:76.
8. Jitkaew S, Trebinska A, Grzybowska E, Carlsson G, Nordström A, Lehtiö J, Fröjmark AS, Dahl N, Fadeel B.
N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed
human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1. J Biol
Chem. 2009 Oct 9;284(41):27827-37.
9. Mohan S, Konopinski R, Yan B, Centonze, VE, Natarajan M. High glucose-induced IKK-Hsp-90 interaction
contributes to endothelial dysfunction. American Journal of Physiology-Cell Physiology , 296:C182-C192 JAN
2009
10. Natarajan M, Mohan S, Konopinski R, Otto RA, Herman TS. Induced telomerase activity in primary aortic
endothelial cells by low-LET gamma-radiation is mediated through NF-kappa B activation. British Journal of
Radiology 81: 711-720 SEP 2008
11. Fadeel B, Grzybowska E. HAX-1: a multifunctional protein with emerging roles in human disease. Biochim
Biophys Acta. 2009 Oct;1790(10):1139-48. Review.
ZAKŁAD ONKOLOGII MOLEKULARNEJ I TRANSLACYJNEJ
PUBLIKACJE PEŁNOTEKSTOWE
12. Carlsson G, Elinder G, Malmgren H, Trebinska A, Grzybowska E, Dahl N, Nordenskjöld M, Fadeel B. Compound
heterozygous HAX1 mutations in a Swedish patient with severe congenital neutropenia and no
neurodevelopmental abnormalities. Pediatr Blood Cancer. 2009 Dec;53(6):1143-6
13. Carlsson G, van't Hooft I, Melin M, Entesarian M, Laurencikas E, Nennesmo I, Trebińska A, Grzybowska E,
Palmblad J, Dahl N, Nordenskjöld M, Fadeel B, Henter JI. Central nervous system involvement in severe
congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1
mutations. J Intern Med. 2008 Oct;264(4):388-400.