مقایسهی اثر ضد دردی فلونیکسین مگلومین و کتوپروفن در درد حاصل از
Transkrypt
مقایسهی اثر ضد دردی فلونیکسین مگلومین و کتوپروفن در درد حاصل از
ƱŚºŬƳŻƾºĪƃżěƭƺºƬƗƵŚĮºƄƳřŵƾƄƷƹĦěƾưºƬƗƽƶƬºŬƯ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 ÎÏŚţΚŚŰºƠƇÎÐÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹ ƹŵ ŢƿźŤǀƳƾƀƧřźěŻřƪƇŚůŵŹŵŹŵƲƟƹźěƺŤƧƹƲǀƯƺƬĮƯƲǀƀƨǀƳƺƬƟƽŵŹŵŶƋźŧřƽƶƀƿŚƤƯ ƽŶƴƷƽƶĤƧƺųŹŵ æ èƲǀŬƄƷƾƣŵŚƇ ŻŹŵƺĭźŤĩŵçŹƺěƾƳŚŴƬƿřƺƴǀƯźŤĩŵ ƾƯŶƤƯũźƿř [email protected]ƱŚŬƳŻƱŚŤſřƁŹƹźěƹƁŻƺƯōƱŚƯŻŚſƱŚŬƳŻƩƺŘƀƯƽƵŶƴƀƿƺƳ ííìææƁźƿŸěíëæææåŢƟŚƿŹŵ ƵŶǀƨģ ƲºƿřŶºƳźǀĭƾºƯŹřźºƣƵŵŚƠŤºſřŵŹƺºƯŜţƹŵŹŵśŚƸŤƫřƱŚƯŹŵŹŵƖǀſƹŹƺƏƶŝNSAIDsƽŶǀŗƹźŤſřźǀƛśŚƸŤƫřŶƋƽŚƷƹŹřŵƝŶƷƹƶƴǀƯŻ ƹƲǀƀƨǀƳƺƬƟƽƹŹřŵƹŵŚŝƱŚƯŹŵƹŢƿźŤǀƳƾƀƧřźěƭŚƳƶŝƽƺƣƺǀţřŶǀƀƧřŢǀƇŚųŚŝƦƿĥƺƫƺǀŝƽƵŵŚƯƦƿŚŝƾŝźŬţśŚƸŤƫřŵŚŬƿřƝŶƷŚŝƂƷƹĦě ŶƿŵźĭƭŚŬƳřƲƟƹźěƺŤƧ ƾºƠƴƯŶƷŚºƃƩźŤƴƧƵƹźĭƶŝƹŢƿźŤǀƳƾƀƧřźěƵƹźĭƶſƶŝŶƳŶƃƮǀƀƤţƾƿŚţëƵƹźĭéŹŵƽŶƴƷƶĤƧƺųƶƘƐƣçéŹƺƔƴƯƲƿřƶŝƾſŹźŝƁƹŹ ƲǀƯƺºƬĮƯƲǀƀºƨǀƳƺƬƟƽƹŹřŵƹŵśŚºƸŤƫřŻƹźºŝŻřƲǀºƤƿƩƺƈºůƹŵŚºŬƿřŻřžºěŶºƃƢºƿŹżţŚºěƞƧŹŵƽŶƬūźƿŻƢƿźƏƶŝƽĥƺƫƺƿżǀƟƭźſ ƶºŝƹŢƗŚºſæçƪºƇřƺƟƶºŝŹŚºŝêŵřŶºƘţƶŝŹŚƸģƹƶſƽŚƷƵƹźĭŹŵŜǀţźţƶŝ ƭźĭƺƬǀƧŹŵƭźĭ çƲƟƹźěƺŤƧƹƭźĭƺƬǀƧŹŵƭźĭƾƬǀƯæ ƾƬǀƯ ƞƧŹŵƽŹŚƄƟŵŹŵźŝřźŝŹŵŢƯƹŚƤƯƱřżǀƯƢƿŹżţźƷŻřŶƘŝƹƪŞƣŢƗŚſƦƿŶƃƢƿŹżţƽĥƺƫƺƿżǀƟƭźſŜǀţźţƱŚưƷƶŝżǀƳƹŵƹƦƿƽŚƷƵƹźĭ ŶƃƽźǀĭƵŻřŶƳřƶƏƺŝźƯƽŚě ŵƺºŝƵřźºưƷƂƿřżºƟřŚŝŶƳŵƺŝƵŵźƧŢƟŚƿŹŵŢƿźŤǀƳƾƀƧřźěƶƧƾƿŚƷƵƹźĭ ƽƶǀƬƧŹŵƽŹŚƄƟŵŹŵƶŝŚěŢǀſŚƀůƶƧŵřŵƱŚƄƳƶƘƫŚƐƯŪƿŚŤƳŚƷƶŤƟŚƿ ƮŬƴºěƹƭŹŚºƸģƭƺºſƢƿŹżţŻřŶƘŝƽźŧřƲǀƴģƾƫƹŵřŵƂƷŚƧřŹŵŹŵƶŝŢǀſŚƀůƽźŧƺƯšŹƺƇƶŝƹŹřŵƹŵźƷƭƹŵƹƩƹřƢƿŹżţP<ååê ŶƄƳƵŶƷŚƄƯ ŹŚǀƀºŝŹŚƄºƟŻřƪƇŚůƽŚƷŵŹŵƱŚƯŹŵƽƶǀƫƹřšŚƗŚſŹŵNSAIDsƽŚƷƹŹřŵźŧřƶƧŶſŹƾƯźƔƳƶŝƵŶƃƭŚŬƳřšřŶƷŚƄƯŽŚſřźŝƽźǀĭƶŬǀŤƳ ŶƷŵƾƯƱŚƄƳƂƴƧřƹŵƺųƽŚěƽƶĤƴěŹŵƾƧŶƳřŹŚƄƟŚŝƽŶƴƷƶĤƧƺųƹƶŤƟŚƿƂƷŚƧŚƷƹŹřŵźŧřƱŚƯŹŵƾƳŚƿŚěšŚƗŚſŹŵƶŤƟŹƶŤƟŹƲƨǀƫŢſLJŚŝ ƱŚºƯŹŵƩƺƏŹŵŢſřƲƨưƯřźƿŻŢſřŢǀưƷřżŗŚůŶƴƴƧƾƯƵŵŚƠŤſřNSAIDsƽŚƷƹŹřŵŻřšŶƯƾƳLJƺƏšŹƺƇƶŝƶƧƾƳřŹŚưǀŝŹŵƕƺƋƺƯƲƿř ŶŝŚƿƂƷŚƧŚƷƹŹřŵźŧř ŢƿźŤǀƳƾƀƧřźěƲƟƹźěƺŤƧƲǀƯƺƬĮƯƲǀƀƨǀƳƺƬƟŵŹŵśŚƸŤƫřƽŶǀƬƧƱŚĭĥřƹ ƶºưǀƳæŵƺºƃƾºƯƪƇŚůŶƿŚƀƧřźěƺſƹŶƿŚƀƧřƦƿźŤǀƳƲǀŝ ƶƯŶƤƯ ƦºƿƹƽƺºƣƽƵŶºƴƴƧŶǀƀºƧřƪºƯŚƗƦƿŢƿźŤǀƳƾƀĩřźě ƽŚºƷŵźºƨƬưƗŻřƾºƨƿçŢºſřƶºƤǀƣŵƦƿƎƤƟŵřźĭƾŤƳŚſ ƖƿźºſƂƴºƧřƹŻřƶºƧŢºſřƽřƵŵŚƯŢƿźŤǀƳ ƾƀĩřźě ŶƃŚŝƾƯ ƽƶºūŹŵÐÔ ƽŚºƯŵƹÔÑ źºŝřźŝPH ŹŵŢºƿźŤǀƳƾƀƧřźěźưƗ ƶǀƯƹŹřƵŚĮƄƳřŵŹŚƿŵŚŤſřƽĥƺƫƺƿżǀƟƾƈƈŴţƽřźŤĩŵç ŚºƷƩƺƬºſƽƹŹźºŝźƌºƯšřźºŧřŚºŝƵřźưƷƩŚƘƟŹŚǀƀŝŜǀƧźţ ƱŚŬƳŻƱŚŤſřƁŹƹźěƹƁŻƺƯōƽŹƺƳŚūƽĥƺƫƺƿżǀƟŶƃŹřŽŚƴƃŹŚĩæ ƱřźƸţƵŚĮƄƳřŵŹŚǀƄƳřŵƽĥƺƫƺĩŚƯŹŚƟƾƈƈŴţƽřźŤĩŵè ŵŹŵƹśŚƸŤƫřźŧřƽƶƘƫŚƐƯ ŵƺºƃƾºƯŢºƟŚŝƶºŝƶƯŶºƇŜºūƺƯŢºƿźŤǀƳƾƀƧřźěƎſƺţ ƶºƧŢſřƱōƦǀƀƧƺţƺŤǀſŢǀƫŚƘƟŢƿźŤǀƳƾƀƧřźěƽƶŤƀūźŝ ŹŵŢºƿźŤǀƳƾƀƧ řźěŻřƮǀƤŤƀƯƽƵŵŚƠŤſřŶƳŻƾƯƶƯŶƇŚƷƂƃ ƲººƿřŶººƃŚŝƶŤººƃřŵŢººƫŚųŵƦǀƀººƧƺţƺŤǀſƩŚººưƗřŻřƾƌººƘŝ ŹŵżºǀƳƮƿŶºſƽŚºƷƩŚºƳŚƧƶŝƶƧŵŹřŵŵƺūƹŹƹŚŝƲƿřƲǀƴĤưƷ ƾ ŤƟŚºŝ ƽƶƯŶºƇ ƹśŚºƸŤƫřƱŶƃřŶǀěŜūƺƯƾƿřƺƷƽŚƷźǀƀƯ ŹŚǀƀºŝƽŚºƷŲºſŚěƪƯŚºƃƾŝŚºƸŤƫřƽŚºƷŲºſŚěìŵŵźºĭƾºƯ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 2 šźūŚºƸƯŚŝƾƫƺƬſƽŚƷŲſŚěŢſřƾƳƺųƹ ƾƫƺƬſĬƴƷŚưƷ ŚƷŢǀſƺƧƺƫƲƿřŢſřƵřźưƷƵŶƿŵƶƯŶƇƪŰƯƶŝŚƷŢǀſƺƧƺƫ ƹ(PMNS)ƽřƶŤƀƷŶƴģƽŚƷŢǀſƺƧƺƫƹŚƷĥŚƟƹźƧŚƯƪƯŚƃ ƱƺºģƾƿŚºƷƾŬƳŚºǀƯƶŤſƺǀěŹƺƏƶŝƶƧƽŚƷŢǀſƺƠƴƫƲǀƴĤưƷ řŹŚºƷƲǀƧƺŤǀºſƹŚƷƲǀƧƺƫ źŤƴƿřŚƷŶǀŗƺƳřŻƺƧřŵŚůŻŚƟƲǀŘţƹźě ƦºưƧƪƯŚƗƦƿřŹŵŹŵƱƺŤĮƴƿźƃíŶƴŤƀƷŶƴƴƧƾƯŮƃźţ ƽŚƷƥźŰƯ.ŶƳřŵƾƯƽŹŚŞūřƾŤƓŚƠůžƨƬƟŹƦƿƽřźŝƾƳřƹŹ ƽƺºƣƽƵŶºƴƴƧśŚºƴŤūřƹƵŶƴƄºƧŜƤƗŲſŚěŻƹźŝŜūƺƯŵŹŵ ŹŵŢſřƲƨưƯŜǀƧźţƲƿřƹŶƷŵƾƯűŹŚƷƱĥƺţŚěźǀŧŚţŢŰţ ƽŶººǀĜǀƫƱƺǀſřŶǀƀººƧřźěƕƹźººƃŶººǀƬƧƱřƺººƴƗƶººŝŜººǀƧźţ ƦǀţŚƯƹŹōƽŚƷŶǀſřƺƴǀƯōƱƺǀſřźŤǀƳƹƾƬƿŹŶǀƠƫƺſƱƺǀſřŶǀƀƧř ƲºƨưƯŚºƷƂƴºƧřƹŻřƾºųźŝ ŢſřƵŶƃƶŤųŚƴƃƲƿŻƹźǀţƪŨƯ ƾºŞƿźŴţŢºǀƫŚƘƟŜƣŚƘŤƯŢƄĭźŝƪŝŚƣźǀƛŜǀſōŦƗŚŝŢſř ƾºƠƬŤŴƯƽŚºƷƩƺºƨƫƺƯŢſřŹŵŚƣƱƺǀƳōƲƿřƲǀƴĤưƷ ŶƳŵźĭ ƩŚºƘƟŚºŝřŹƾƿŚƄºƛƽŚºƷŶǀĜǀƫƺƠƀºƟƹŻƺŞƿŹŶǀƀƧřƽŵźǀƔƳ ƾƀººƧřźěèŶº ƿŚưƳŶǀƀººƧřƪǀƀººƧƹŹŶǀƷƩŚººƨƿŵřŹƲŤųŚººſ źºŝźºŧřŚºŝřŹśŚºƸŤƫřƽƶºǀƫƹřƪºůřźƯƩƺƬſƪųřŵŹŵŢƿźŤǀƳ ƾƇŚƈºŤųřŹƺºƏƶºŝƵŵŚºƯƲºƿřŶºƴƧƾºƯƩŚưƗřŚƷŢǀſƺƧƺƫ Extracellular Signal Regulated KinaseERKƱŶºƃƩŚºƘƟŜūƺƯ ƹ ŢºſřƱŶºŝƾƗŚºƟŵƮƀºǀƳŚƨƯƵŶºưƗŹƺºƏƶºŝŵŹŵŵƺƃƾƯ ŵŵźºĭƾƯ UP RegulationƶŝźŬƴƯƶƧƵŶƃŚƷƪǀƟƹźţƺƳŹŵ ŵŹřŵƾºƯźŝƱŚºǀƯŻřřŹŵŹŵŶƫƺƯŽƺƫƺưǀŤſřƹŵƺƃƾƯƆŴƃ ŶƴŞƀºģƾºƯƩŚǀƬţƹŶƳřƶŝƽřƶŤƀƷŶƴģƽŚƷŢǀſƺƧƺƫƂƿřżƟř ƂƴºƧřƹŜºūƺƯŢºſřƵŶºƃŜǀºſōŹŚºģŵŢƟŚŝ ƶƧƾƯŚĮƴƷ ŵŹŵŶºƋŢǀºƇŚųƽŶǀŗƹźŤºſřźǀƛśŚƸŤƫřŶƋƽŚƷƹŹřŵî ƲƯżºƯƽŚƷŵŹŵƕřƺƳřƱŚƯŹŵŹŵƹŶƳŹřŵŜţŶƋƹśŚƸŤƫřŶƋ śŚººƸŤƫřŶººƋƽŚººƷƹŹřŵ æåŶººƳƹŹƾººƯŹŚººƧƶººŝŵŚººůƹ ƹŵƽřŹřŵƶººƧŻŚƳĦǀƀººƧřƺƬƨǀººſƭżºƳōŹŚººƸƯŚººŝƽŶǀŗƹźŤººſřźǀƛ ƾƿŚºƷƲǀŘţƹźě ŚƷƭźƟƹżƿř Ţſř COX-1COX-2ƭźƟƹżƿř ƾºƨƿŚºƷƱōƶºƴǀƯōƽŚƷŶǀºſřƹŶƳŹřŵƮƷƶǀŞƃƪưƗƶƧŶƴŤƀƷ ƲǀººƴĤưƷƹŶººƳřƵŶººƃŶººǀƫƺţƾţƹŚººƠŤƯƽŚººƷƱĥŻřŚººƯřŢººſř ƪºưƗŶƳƺºƃƾºƯŢºƟŚƿŵƺºųƶºŝƅƺƈºŴƯƽŚºƷŢƟŚŝŹŵ ŢºſřƍŚºŞţŹřŹŵŜºţƹśŚºƸŤƫřŵŹŵŚºŝCOX-2ŶºƴƴƧƾƯ ƾƘƣřƺºƯŹŵƹŶƴŝŚƿƾƯƂƿřżƟřŚƷƲǀƧƺŤǀſƹƾŝŚƸŤƫřƽŚƷŹƺŤƧŚƟ ææŶƳƺƃƾƯƵŶƿŵźŤƄǀŝŶƷŵűŹƱŶŝŹŵƾţŚůřźūƶƧ ŶƿŚƀºĩřźěƺſŚŝŵŹŵƹśŚƸŤƫřŵŚŬƿř ƢǀƤŰţƲƿřƭŚŬƳřŻřƝŶƷ ƞºĩŹŵƽŶºƬūźºƿŻƮǀƤŤƀºƯƢƿŹżţƁƹŹƶŝŢƿźŤǀƳƾ ƀĩřźě ƾƳřƺǀůƩŶƯŹŵŵŹŵƪưŰţƱřżǀƯƂŬƴſ ƽŶƴƷƶĤĩƺų ƽŚě šřźºŧř ƾſŹźŝ ƽŹŚƄƟŪƴſŵŹŵƵŚĮŤſŵƎſƺţ ƽŶƴƷƶĤĩƺų ƾºěŹŵƶºƧƵŶºƿŵźĭCD4/CD8ƱĥƱŚǀŝŜūƺƯƶŬǀŤƳŹŵƹ ŚºŝŚºƷŢǀſƺƨƫƵŶƿŵŜǀſōƪŰƯŻřƱōƱŵƹŵŻƽřźŝƶŬǀŤƳŹŵ ŚºƷŢºƟŚŝźƿŚſŻřƵŶƿŵŜǀſōŢƟŚŝƱŵźƧřŶūƹśŚƸŤƫřŵŚŬƿř ŶƳƺºƃƾƯŚƷ ŢƟŚŝźƿŚſƶŝ ƶƘƿŚƋŢƟźƄǀěŻřƽźǀĭƺƬūŜūƺƯ ƦƿŶƴƳŚƯŢƿźŤǀƳƾƀƧřźěƶƧŶƷŵƾƯƱŚƄƳźǀųřšŚƘƫŚƐƯé ƾƬěƺºĜǀƫŹŵÕƲǀƧƺºƫźŤƴƿřƱĥƾŬƳŚºǀƯƾƫƺƬſƱƹŹŵƱŚſŹƭŚǀě ƶºĩŢºſřÎƲǀƧƺƫźŤƴƿřƹžƿŻƹźĪƳŹƺƯƺţŹƺŤĩŚƟ ŚƷŶƿŹŚƧŚſ ŶºƴƧƾºƯƩŚƘƟřŹŚƸƳōƹƵŶƃŶǀƠſƽŚƷƩƺŞƬĭƦƿźŰţŜūƺƯ ŚºƷƪǀƟƹźţƺƳƽƵŶƴƴƧƩŚƘƟƹŻřŶƳřƵřŹƦƿƱřƺƴƗƶŝÕƲǀƧƺƫźŤƴƿř ƶƳƺĭźƷŵŹřŵƂƤƳśŚƸŤƫřƾŝźŬţƽŚƷƩŶƯŹŵŚƷŢǀſƺƳƺƯƹ IL-8ŹŚºƸƯŜºūƺƯŢſřƲƨưƯƱōƽźǀĭƪƨƃŻřƽźǀĭƺƬū êŶºƃŚŝŶºǀƠƯƾŝŚƸŤƫřŶƋźŧř Ʀƿ ŶƳřƺţƾƯźƯřƲƿřƶƧ ƵŶƃ ƹŚºƷšřŹŶǀƷ ƺŝźƧƹŚƷƲǀŘţƹźěŚƷŶǀĜǀƫŢſřŹŵŚƣŢǀƫƺŝŚŤƯƲƿř ƶºţřźŤǀƳƹƶƬǀƀºƧƹŹŶǀƷŚºŝƶƧŶƴƧŶǀƀƧřřŹƦǀŘƬƧƺƳƽŚƷŶǀſř ƹŢºƿźţŹōžƿŻƹźƬƨºſřƹźţŹōƾŝŚºƸŤƫřšLJŚůŜūƺƯƱŵźƧ ŚƄƛƽŚƷŶǀĜǀƫƱƺǀſřŶǀƀƧřźěëŵŵźĭƾƯ žƠƳƾĮƴţƽŹŚưǀŝ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ 3 ƱřŹŚƨưƷƹƾƯŶƤƯũźƿř çætçƽŚºƯŵƹƾƨƿŹŚºţŢƗŚºſ æç ƹƾƿŚƴƃƹŹŢƗŚſ æç ƲǀƯƺººƬĮƯƲǀƀººĪǀƳƺƬƟƽŶǀŗƹźŤººſřźǀƛśŚƸŤƫřŶººƋƽŚººƷƹŹřŵ ŶƳŶƃƽŹřŶƸĮƳ ƂºƤƳƵŶºƃŻŚƳĦǀƀºĩřƺƬĪǀſŹŚƸƯŜūƺƯƾŝŚŴŤƳřźǀƛŹƺƏƶŝ ƎǀŰƯŚŝƽŹŚĭŻŚſƽřźŝƶŤƠƷƦƿšŶƯƶŝŵřźĭƾŤƳŚſƽƶūŹŵ ƽŚºƷƵƹźºĭŹŵŜǀţźţƶŝƾƿŚţëƵƹźĭ é Źŵ ƽŶƴƷ ƽŚƷƶĤĩƺų Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 ƵƹźººĭçƵƹźººĭŢº ƿźŤǀƳƾƀººĩřźěƵƹźº ĭæƵƹźººĭƩźººŤƴĩ ƵƹźºĭƹèƵƹźºĭŢºƿźŤǀƳ ƾƀºĩřźě Śºŝ ƲǀƯƺºƬĮƯƲǀƀĪǀƳƺƬƟ ƱřżºǀƯƶºŝŶºƴŤƟźĭŹřźƣéƵƹźĭ ŢƿźŤǀƳ ƾƀĩřźě Śŝ ƲƟƹźěƺŤĩ îŚººŝƵŶººƃżŤƴººſƆƫŚººųŢº ƿźŤǀƳƾ ƀººĩřźěŻřźººŤǀƫƹźĪǀƯìç ƹŵźºƷƶºĩƾƳŚƀƳřƝźƈƯŚŝƲƟƹźěƺŤĩƹƾƯřŵƝźƈƯŚŝ ƾºƤƿŹżţ ƾƿƹŹřŵƪĪƃŵƺūƹŵƺŝŶƳŹřŵ ŵŹŵŶƋƹ ƾŝŚƸŤƫřŶƋ ŵƺŝŚƷƱōśŚŴŤƳřƪ ǀƫŵƹŹřŵƹŵƲƿř ƾſŹźŝƁƹŹ ŹƺººŤĩřŹĨººƿŻřƾƿŚǀưǀººƃƽƵŵŚººƯƲ ººƿřżŤƴººſƽřźººŝ ƱřƺǀůĚģ ƽŚěƞĩƶŝŶƿŵźĭƢǀƣŹ ƽĥƺƫƺƿżǀƟƭźſźŤǀƫƾ ƬǀƯ NaNo2 ƽŚºƷƩƺºƬŰƯŶºƿŵźĭƵŵŚƠŤºſř Quenched Flow żºǀƳƱřƺºǀůŢºſřŹ ƽŚºěƶŝƱŚƴǀưƏřŢƸūŶƃƢƿŹżţ ƽŶƬū źºŤǀƫƾ ºƬǀƯÏÒŢƗźºſŚŝ T ƩŚƈţř ŚŝƽřƶƄ ǀƃŹƺŤĩřŹƪųřŵƶŝ ƽƵŶƷŚƄººƯŚººŝŻƹŹƶººſŻřžººěŵƺººưƳŢººƟŚƿŹŵƽĥƺººƫƺƿżǀƟ ƱŶºƃƵŵƹżºƟřŚºŝƶĩŵƺŝŶǀſřŻƹźŤǀƳƶƬƇŚůƩƺƬŰƯŶƳŶƿŵźĭ ƱŚºƴǀưƏřƹŢºſřŹƽŚěŚŝƶƀƿŚƤƯƹžǀƫƺƧŚŝŚěƞƧŢƯŚŴƋ ƶºŝƽřƶƄ ǀƃƽƶƫƺƫ ƽŚƸŤƳřŹŵ T ƩŚƈţřŚŝƭƺſƽřƶƄ ǀƃƽƶƫƺƫ ƶºŝÑƹÐƽŚºƷƵƹźĭƶŝƹźŤǀƫƾƬǀƯÍÒƽĥƺƫƺƿżǀƟƭźſƹŵƹ ƪºǀƫŵƶºŝŶºƃ ƽŹřŶƸĮƳŵřźĭƾŤƳŚſƽ ƶūŹŵ çåŹżƿźƟŹŵƶŤƠƷ ƽŶºƬūźƿŻƢƿźƏƶŝƭźĭƺƬǀƧŹŵƭźĭƾƬǀƯçŻƹŵŚŝƲƟƹźěƺŤƧ ŵřŵƪǀĪƄºţƵŶƃŶưŬƴƯƩƺƬŰƯƂŴŝ Ʋƿźţƾƿ LJŚŝŹŵřŹĬƳŹ ŶºƿŵźĭƭŚºŬƳřƱřƺǀůŢſřŹƽƶƳŚƃƝźƏŹŵÎÖŢƗŚſŹŵƹ ŚºŝƶºƿLJƲƿřŹŵŢƿźŤǀƳƾ ƀĩřźěŢƔƬƛŶƿŵźĭ ƽŹřŶƸĮƳŹżƿźƟ ƵŚĮŤſŵƲƿřŢƟźĭƭŚŬƳřŚǀƫŚŤƿřŢųŚſCATƥŹŚƯŚŝƽŹŚƄƟ ŹŵŢºƿźŤǀƳ ƾƀºĩřźěƒǀƬƛħŚŤſř ƽŚƷƩƺƬŰƯ ŶƿŵźĭƲǀǀƘţ ŹŵŚºěƽƶŬƴěƶƧŢſřŜǀţźţƲƿřƶŝŹŚƧƽƵƺŰƳŢſřƽŶƴƷ ƵŵŚƠŤſřŵŹƺƯƾŗŚǀưǀƃŵřƺƯƽƶǀƬĩèŶƿŵźĭƲǀǀƘţƵŵŚƠŤſřŻř źºƿŻƢºƿźƏƶºŝƾºſƾºſŪƴºěƹŹŚƸģƹƶſƹŵƽŚƷƵƹźĭŹŵ ƩŚƯźƳ ŶƇŹŵÔH2O2ƩŚƯźƳ ŶƇŹŵëHclƩŚƯźƳ ŶƇŹŵ ë ƭźºſ ƾºſƾ ºſê żǀƳƩźŤƴĩƵƹźĭŶƃƢƿŹżţ ƽĥƺƫƺƿżǀƟƭźſ ƍƺººƬŴƯƽřƶƄ º ǀƃƽƶººƫƺƫƪººųřŵŹŵƹŶººƃĚººưěƶººƤǀƣŵŹŵ ƽźºǀĭƵŻřŶºƳřƹƭŹƺºţƹƽżƯźƣƾƯźĭŶƴƳŚƯśŚƸŤƫřƽŚƷƶƳŚƄƳ ŻřƹŢƗźºſƱŚºưƷŚºŝƮƿŶºſŶǀƀĩƹŹŶǀƷŹLJƺƯ ÎÒƩƺƬŰƯ ƦºƿƽŚºƷƵƹźĭƶŝŢƗŚſ ÎÏƽƶƬƇŚƟŚŝŹŚŝ ÒśŚƸŤƫřŻƹźŝŻř ĨƿšŶƯƶŝƾƿŚƸƳƩƺƬŰƯŶƿŵźĭƪƿŶŞţŻƹźŤǀƳƾƀĩƹźěŶǀſř ƹƭźºĭƺºƬǀƧŹŵƭźĭƾƬǀƯæŻƹŵŚŝƲǀƯƺƬĮƯƲǀƀƨǀƳƺƬƟŜǀţźţ ŵŹŻƽƶºƿLJĨºƿ ŢºƿźŤǀƳ ƾƀºĩřźěŵŚưŬƳř ƽƶƐƤƳŹŵšƹŚƠţ ĚºģƽƶƳŚƃƝźƏŹŵŮŞƇìŢƗŚſƢƿŹżţÎÏŶƃƢƿŹżţ ŹŵƱōŻř ƵŵŚƠŤºſřƹƽŶƘŝżǀƫŚƳōƽřźŝƹŶƃƵŶǀƃřźţƂŴŝƲƿř ŪƴºſŵŹŵƵŚĮŤºſŵƎºſƺţƾŬƴºſŵŹŵƢƿŹżţźƷŻřŶƘŝƹƪŞƣ źºŤƯƺƳŚƳ ÐÍÏśŸūƽƶƐƤƳŹŵ ƽŹƺƳźŤƯƺŤƟƹźŤĪĜſř ŻřƵŵŚƠŤſř ƽƶĤƧƺųƹƶŝźĭƁƺƯƱƺģƾţŚƳřƺǀůŹŵƾŬƴſŵŹŵƆŤŴƯ ƂǀºěŹŚŝźƷŚƸƳōŢƔƬƛƹƽŹřŶƸĮƳƾƿŚǀƬƣƎǀŰƯŹŵƹŹżƿźƟ ƩřŶºěƽźºǀĭŹŚºƧƶºŝŚºŝžĜſ ƶŤƟźĭŹřźƣƵŚĭƶǀƨţƹƭźƷřƲǀŝ ŶºƿŵźĭƽŹřŶºƿźųƱŚºưƫōħźºƯŢĩźºƃ ŻřƂƷƹĦºěƲƿřŹŵ ŵƺºƃƾºƯƵŵřŵƂƿŚưƳƭźĭŜƀůźŝũŹŶƯƂƧƎųƽƹŹźŝ ƶºǀƯƹŹřƵŚĮƄºƳřŵƽƶºƳŚųƱřƺǀůŻřƱŚƀƨƿĚǀţƺƴƟŚŝźƳƽŶƴƷ ƽŚěƹƖƐƣřŹŹŚƄƟƶƬƇŚƟLjŝŶƿŚưƳƾ ƯLjƤţƶŝƕƹźƃƾƿŚūŹŵ ƭźºĭêååŚºƷƱřƺºǀůƱŻƹƎſƺŤƯƹŶƳŶƃƲƿŻƺţŚƷƱōŶƳŵƺŝ ƱŚºƯżưƷŶŝŚƿƾƯƂƿřżƟřŪƿŹŶţƶŝƺƌƗźŝŹŚƄƟƱřżǀƯƶƏƺŝźƯ ƽƶºĤƧƺųƽƶºƘƐƣçéŵřŶºƘţƾŝźŬţƂƷƹĦěƲƿřƭŚŬƳřƽřźŝ ƱřƺºǀůŵŵźĭƾƯƆŴƄƯƱřƺǀůƪưŰţƱřżǀƯŹŚƄƟƂƿřżƟřŚŝ ƾƴǀƫŚºŝƮºŗLjƗŚºŝƆŴƄƯƽŹŚưǀŝŶƣŚƟŚƷƶĤƧƺų ŶƿŵźĭƶǀƸţ æèƹæéŵƺºƃƾƯŢƃřŵŚƿƶƏƺŝźƯŵŶƗ ƵŵƺưƳŵřŻōřŹƱřƺǀů ŹƺººƳƑŚººŰƫŻřƩźººŤƴƧƎƿřźººƃŹŵŚººƷƱřƺººǀůŶººƿŵźĭƲǀººǀƘţ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ ŵŹŵƹśŚƸŤƫřźŧřƽƶƘƫŚƐƯ ƦºƿŹŵŵŹŵƪºưŰţƽƶƳŚŤºſōƭƹŵƵƹźºĭŹŵP=ååçŵƺºŝ ŶºƘŝƹƪºŞƣŪƿŚŤƳƹƾŝŚƿŻŹřƶƳŚĭŹŚƸģƽŚƷƵƹźĭŪƿŚŤƳƲǀĮƳŚǀƯ šƹŚºƠţ ŶƇŹŵ åìŚƸƴţƽĥƺƫƺƿżǀƟƭźſƢƿŹżţŻřžěŢƗŚſ ƱƺºƯŻōƶºŝƭƺºſƺƯżǀƫŚºƳōŻřƵŵŚƠŤºſřŚºŝ ŚƷƵƹźĭŹŵƢƿŹżţŻř ƱřżǀƯƶŝƹŹřŵƢƿŹżţŻřžěŢƗŚſƦƿƾŬƴſŵŹŵŪƿŚŤƳƭƺſ ŶƿŵźĭƾƤƬţŹřŵƾƴƘƯƽŹŚƯō ƵƹźĭŹŵP=ååèŵƺŝŹřŵƾƴƘƯƽŹŚƯōƑŚŰƫŻř ƶƧŵřŵƱŚƄƳ źºƔƳŻřšƹŚºƠţŵƺŝP<ååêƶƧƾţŹƺƇŹŵƹŶƃƶƀƿŚƤƯT ƑŚŰƫŻřŚƯřŵřŵƂƿřżƟřřŹŵŹŵƶŝƱřƺǀůƪưŰţ ŶƇŹŵ çìæê ŵŹŵƪºưŰţƭŹŚºƸģƵƹźĭŹŵP=ååîŵƺŞƳŹřŵƾƴƘƯƽŹŚƯō ƶºūƺţƪºŝŚƣƱřżǀƯƶŝƹŹřŵƢƿŹżţŻřžěŢƗŚſƦƿƱřƺǀůŹŵ ŚƷƶŤƟŚ ƿ ƭźººſƢºƿŹżţŻřƪºŞƣƾŬƴººſŵŹŵŪƿŚºŤƳƩźºŤƴƧƵƹźºĭŹŵ æŹřŵƺưƳP=åæ ŹřŵƾƴƘƯƽŹŚƯōƑŚŰƫ ƶƬŘƀƯƲƿřŶƄƳƪƇŚůƽźǀǀƜţƱřƺǀů Żř ŵŹŵƪºưŰţŹŵƹŵƺºŝƱŚƀƨƿƭźſƢƿŹżţŻřŶƘŝƹƽĥƺƫƺƿżǀƟ ŵƺºŞƳŹřŵƾºƴƘƯƽŹŚºƯōƑŚŰƫŻřŚƯřŢƟŚƿƂƿřżƟřŶƇŹŵíæì 600 500 ¹³\u]Z§ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 4 400 300 200 100 con per per+flu per+ket con per per+flu per+ket ŢſřŹŢưſƢƿŹżţŻřŶƘŝŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯ ĚģŢưſƢƿŹżţŻřƪŞƣŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯ æŹřŵƺưƳ *P<ååêƲƟƹźěƺŤƧƢƿŹżţƵƹźĭKetoƲǀƨǀƳƺƬƟƢƿŹżţƵƹźĭFluŢƿźŤǀƳƾƀƧřźěƢƿŹżţƵƹźĭPerƽĥƺƫƺƿżǀƟƭźſƢƿŹżţƵƹźĭCon źƠƇŢƗŚſŹŵƽřƶƀƿŚƤƯŹřŵƺưƳ ƦºƿŵƺºŝƵŵƺºưƳŢºƟŚƿŹŵřŹƲǀƀºƨǀƳƺƬƟƽƹŹřŵƶºƧƾƷƹźĭ ƶƧŵřŵƱŚƄƳƩźŤƴƧƵƹźĭŹŵŶƘŝŢƗŚſæçŹŵŵŹŵƽźǀĭƵŻřŶƳř ƶºƧƾºƷƹźĭŹŵP=ååèŵƺºŝŹřŵƾºƴƘƯƽŹŚƯōƑŚŰƫŻřƶƧ ŻřƶºƧŵřŶºƳűŹŵŹŵƶºŝƪºưŰţƽƶƳŚŤºſōƑŚŰƫŻřƽĥƺƫƺƿżǀƟ ŶƃƵŵřŵƱŚƄƳřŹŶƇŹŵ ççîê ƱřżǀƯƶŝŵŹŵƶŝƪưŰţƂƿřżƟř ƶºŝƪưŰţƂƿřżƟřƦƿŵƺŝƵŵƺưƳŢƟŚƿŹŵřŹƲƟƹźěƺŤƧƽƹŹřŵ ƽŹŚºƯōƑŚºŰƫŻřƶºƧŵřŵƱŚƄºƳřŹŶƇŹŵçêëìƱřżǀƯƶŝŵŹŵ çŹřŵƺưƳP=ååêŵƺŝŹřŵƾƴƘƯ ƭźºſƢºƿŹżţŻřžºěƹƪºŞƣƵƹźºĭƲƿřŹŵŽƺƀŰƯƽźǀǀƜţ ƾƀººƧřźěƵƹźººĭŹŵP=ååèŵƺº ŝŹřŵ ƾººƴƘƯƽŹŚººƯōƑŚººŰƫ ŶºƇŹŵæéîƱřżºǀƯƶºŝŵŹŵƶºŝƪºưŰţƂƷŚºƧƦºƿŢƿźŤǀƳ ŹŵP=ååéŵƺŝŹřŵƾƴƘƯƽŹŚƯōƑŚŰƫŻřƶƧŶƿŵźĭƵŶƷŚƄƯ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ 5 ƱřŹŚƨưƷƹƾƯŶƤƯũźƿř 600 ¹³\u]Z§ 400 300 200 100 con per per+flu per+ket con per per+flu per+ket ŢſřŹŢưſƢƿŹżţŻřŶƘŝŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯĚģŢưſƢƿŹżţŻřƪŞƣŢƗŚſƦƿƾŬƴſŵŹŵƽ ƶƀƿŚƤƯ çŹřŵƺưƳ *P<ååêƲƟƹźěƺŤƧƢƿŹżţƵƹźĭKetoƲǀƨǀƳƺƬƟƢƿŹżţƵƹźĭFluŢƿźŤǀƳƾƀƧřźěƢƿŹżţƵƹźĭPerƽĥƺƫƺƿżǀƟƭźſƢƿŹżţƵƹźĭCon æçŢƗŚſƽřƶƀƿŚƤƯŹřŵƺưƳ ŶºƇŹŵçìŵŹŵƶºŝƪºưŰţƂƿřżºƟřƦƿŶƳŵƺŝƵŵƺưƳŢƟŚƿŹŵ ƶºƧŵřŵƱŚƄºƳƩźºŤƴƧƵƹźĭŹŵŶƘŝŢƗŚſçéŵŹŵƽźǀĭƵŻřŶƳř ƂƿřżƟřƦƿŶƳŵƺŝƵŵƺưƳŢƟŚƿŹŵƲƟƹźěƺŤƧƽƹŹřŵƶƧƾƷƹźĭ ƶºŝƪºưŰţƂƷŚºƧƦºƿŢƿźŤǀƳƾƀƧřźěƵƹźĭŹŵP=ååç ŹŵP=ååçŵƺºŝŹřŵƾºƴƘƯƽŹŚƯōƑŚŰƫŻřƹŶƃƵŵřŵƱŚƄƳ ƽŹŚºƯōƑŚºŰƫŻřƶºƧŵřŵƱŚƄºƳřŹŶºƇŹŵìíŵŹŵƶºŝƪưŰţ èŹřŵƺưƳP=ååèŵƺŝŹřŵƾƴƘƯ ŵƺºŝŹřŵƾºƴƘƯƽŹŚºƯōƑŚºŰƫŻřƶºƧŵƺºŝƵŶƄƳƪƇŚůƽźǀǀƜţ ƽŹŚºƯōƑŚºŰƫŻřƶºƧŶºƃƵŵřŵƱŚƄºƳŶƇŹŵæêƱřżǀƯƶŝŵŹŵ ƲǀƀºƨǀƳƺƬƟƽƹŹřŵƶºƧƾºƷƹźĭŹŵP=ååéŵƺºŝŹřŵƾƴƘƯ 600 500 ¹³\u]Z§ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 500 400 300 200 100 con per per+flu per+ket con per per+flu per+ket ŢſřŹŢưſƢƿŹżţŻřŶƘŝŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯĚģŢưſƢƿŹżţŻřƪŞƣŢƗŚſƦƿƾŬƴſŵŹŵƽ ƶƀƿŚƤƯ èŹřŵƺưƳ *P<ååêƲƟƹźěƺŤƧƢƿŹżţƵƹźĭKetoƲǀƨǀƳƺƬƟƢƿŹżţƵƹźĭFluŢƿźŤǀƳƾƀƧřźěƢƿŹżţƵƹźĭPerƽĥƺƫƺƿżǀƟƭźſƢƿŹżţƵƹźĭCon çéŢƗŚſƽřƶƀƿŚƤƯŹřŵƺưƳ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ ŵŹŵƹśŚƸŤƫřźŧřƽƶƘƫŚƐƯ ƑŚºŰƫŻřƶºƧŶƃƵŶƷŚƄƯƹŹřŵƢƿŹżţŻřŶƘŝŶƇŹŵíìƱřżǀƯ ƪºŝŚƣźºǀǀƜţƩźŤƴƧƵƹźĭŹŵŶƘŝŢƗŚſèëŹŵŵŹŵƽźǀĭƵŻřŶƳř ƶºŝƪºưŰţƂƿřżºƟřƦƿƭŹŚƸģƵƹźĭŹŵŵƺŝƶŤƟŚƿƂƷŚƧŵŹŵ ƂƷŚºƧƦºƿƪŞƣŻƹŹƶŝŢŞƀƳƭƹŵƵƹźĭŹŵ P=ååè ŵƺŞƳ ƶºŝƪºưŰţżºǀƳƵƹźĭƲƿřŹŵ P=åååé ŵƺŝŹřŵƾƴƘƯƽŹŚƯō ŹřŵƾºƴƘƯƽŹŚºƯōƑŚºŰƫŻřƹŢſřƵŶƄƳƵŵřŵƱŚƄƳƽřƶƔůLjƯ ƽŹŚºƯōƑŚºŰƫŻřƶºƧŶºƃƵŶƷŚƄºƯ ŶºƇŹŵ çé ƱřżǀƯƶŝŵŹŵ ŹřŵƾºƴƘƯƽŹŚºƯōƑŚºŰƫŻř ƶƧŵƺŝƵŶƃƵŶƷŚƄƯŵŹŵƶŝ ƪưŰţ éŹřŵƺưƳP=åååèŵƺŝŹřŵƾƴƘƯ ƶºŝŵŹŵƶŝƪưŰţƂƿřżƟřƦƿƭƺſƵƹźĭŹŵP=åååç ŵƺŝ 600 ¹³\u]Z§ 500 400 300 200 100 con per per+flu per+ket con per per+flu per+ket ŢſřŹŢưſƢƿŹżţŻřŶƘŝŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯĚģŢưſƢƿŹżţŻřƪŞƣŢƗŚſƦƿƾŬƴſŵŹŵƽ ƶƀƿŚƤƯ éŹřŵƺưƳ *P<ååêƲƟƹźěƺŤƧƢƿŹżţƵƹźĭKetoƲǀƨǀƳƺƬƟƢƿŹżţƵƹźĭFluŢƿźŤǀƳƾƀƧřźěƢƿŹżţƵƹźĭPerƽĥƺƫƺƿżǀƟƭźſƢƿŹżţƵƹźĭCon èëŢƗŚſƽřƶƀƿŚƤƯŹřŵƺưƳ 600 500 ¹³\u]Z§ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 6 400 300 200 100 con per per+flu per+ket con per per+flu per+ket ŢſřŹŢưſƢƿŹżţŻřŶƘŝŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯ ĚģŢưſƢƿŹżţŻřƪŞƣŢƗŚſƦƿƾŬƴſŵŹŵƽƶƀƿŚƤƯ êŹřŵƺưƳ *P<ååêƲƟƹźěƺŤƧƢƿŹżţƵƹźĭKetoƲǀƨǀƳƺƬƟƢƿŹżţƵƹźĭFluŢƿźŤǀƳƾƀƧřźěƢƿŹżţƵƹźĭPerƽĥƺƫƺƿżǀƟƭźſƢƿŹżţƵƹźĭCon éíŢƗŚſƽřƶƀƿŚƤƯŹřŵƺưƳ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ 7 ƱřŹŚƨưƷƹƾƯŶƤƯũźƿř źººŧřƲƟƹźěƺººŤƧƹƲǀƯƺººƬĮƯƲǀƀººƨǀƳƺƬƟźººŧřƽƶƀººƿŚƤƯ ƱŚƄƳƩźŤƴƧƵƹźĭŹŵ řŹƽźǀǀƜţ ŢƗŚſ éí ŹŵŵŹŵƽźǀĭƵŻřŶƳř ƶƧƽŹƺƏƶŝ ŵƺŞƳŹřŵƾƴƘƯƽŹŚƯōźƔƳŻřŚƯř ƾƫƹŵƺŝ LJŚŝƹŵźƷ ƶºŝƪºưŰţƂƷŚºƧŶºƇŹŵçåźǀǀƜţƦƿŢƿźŤǀƳƾƀƧřźěƵƹźĭ źƠººƇŢƗŚººſŹŵƲǀƯƺººƬĮƯƲǀƀººƨǀƳƺƬƟƹƲƟƹźěƺººŤƧƽƹŹřŵ ŹŵŵƺºŝP=åæƲƟƹźěƺºŤƧƽřźŝƹP=ååîƲǀƀƨǀƳƺƬƟƽřźŝ ƲƟƹźěƺºººŤƧƹP=ååèƲǀƀºººƨǀƳƺƬƟƽřźºººŝżºººǀƳƽŹŚºººƯō ŚºƷƹŹřŵźºŧřéíƹèëç隌ƗŚºſŹŵŵƺŝŹřŵŚƴƘƯP=ååê ƪưŰţźƔƳŻřƶƧŵřŵƱŚƄƳƂƷŚƧŹŚǀƀŝƶǀƫƹřšŚƗŚſƶŝŢŞƀƳ ƽƹŹřŵźºŧřƲǀºƴĤưƷP<ååêŵƺŝŽƺƀŰƯƱřƺǀůŹŵŵŹŵ ŹŵŚºƯřƹŵƺºŝƲǀƀºĪǀƳƺƬƟŻřźţLJŚºŝçéŢƗŚºſŚºţƲƟƹźěƺŤĩ ƲƟƹźěƺŤĩŻřźţLJŚŝƲǀƯƺƬĮƯƲǀƀĪǀƳƺƬƟźŧřéíƹèëƽŚƷŢƗŚſ ƽƹŹřŵƽLJŚººŝźººŧřƶƫŚƀººƯƲº ƿřŢººƬƗŢººſřƲººĪưƯŶººƿŵźĭ ƱŶºŝŹŵŵŹŵƶºŝƪºưŰţŵŚºŬƿřƹƩƹř ƽŚºƷŻƹŹŹŵƲƟƹźěƺŤĩ ŻƹŹƶºſƾºƏŹŵƹŹřŵƹŵźƷźŧřŶƃŚŝƭƹŵŻƹŹŻřžěƱřƺǀů ŵƺººŝŹřŵƾººƴƘƯƽŹŚººƯōƑŚººŰƫŻřƶººƧŶººƿŵźĭƵŶƷŚƄººƯŵŹŵ ƂƿřżƟřƦƿƹŹřŵƢƿŹżţŻřŶƘŝƲǀƀƨǀƳƺƬƟƵƹźĭP=åååç ƽŹŚºƯōƑŚºŰƫŻřƶºƧŵřŵƱŚƄºƳřŹŶºƇŹŵíæŵŹŵƶºŝƪưŰţ ƹŹřŵƢºƿŹżţŻřŶƘŝƲƟƹźěƺŤƧƵƹźĭP=åååèŵƺŝ ŹřŵƾƴƘƯ ƑŚŰƫŻřƶƧŵřŵƱŚƄƳřŹ ŶƇŹŵ çë ŵŹŵƶŝƪưŰţƂƿřżƟřƦƿ ŵŹŵƽźºǀĭƵŻřŶºƳřêŹřŵƺưƳP=åååçŵƺŝŹřŵƾƴƘƯƽŹŚƯō ŹŚǀƀºŝŢƗŚºſƲºƿřŹŵŚƷƹŹřŵźŧřƶƧŵřŵƱŚƄƳźƠƇŢƗŚſŹŵ ŢƗŚſŹŵP>ååêŵƺŞƳŹřŵƾƴƘƯƽŹŚƯōźƔƳŻřƾƫƹŵƺŝLJŚŝ ŻřƶƧŵƺŝLJŚŝŵŹŵƶŝƪưŰţƂƿřżƟřƑŚŰƫŻřŚƷƹŹřŵźŧřżǀƳ æç ƹçéƽŚºƷŢƗŚºſŹŵP<ååêŵƺŝŹřŵƾƴƘƯ żǀƳƽŹŚƯōźƔƳ ƾºŤůƹŢºƟŚƿƂƷŚºƧƱřƺǀůŹŵŵŹŵƶŝƪưŰţƱřżǀƯéíƹèë ŢƿźŤǀƳƾƀƧřźěƵƹźĭŚŝ ƶƀƿŚƤƯŹŵŚƯř ŵřŵƱŚƄƳƂƷŚƧƱŚƯŹŵ ŵŹŵƪººưŰţƂƿřżººƟřżººǀƳƹŹřŵƢººƿŹżţŻřŶººƘŝŢƗŚººſƦººƿ ëŹřŵƺưƳŵƺŝźţLJŚŝŵŹŵƶŝ P<ååêŵƺºŝŹřŵƾºƴƘƯƽŹŚºƯōźºƔƳŻřŚºƷšŚƗŚºſƲƿřŹŵ ƱřƺºǀůƪºưŰţŢºſřƵŵƺưƳŢƟŚƿŹŵƽĥƺƫƺƿżǀƟƭźſƎƤƟƶƧ ŚºƷšƹŚºƠţƶºƧŵřŶºƳƱŚƄºƳřŹæçƹźƠºƇƽŚºƷŢƗŚºſŶƴƳŚƯ 600 500 ¹³\u]Z§ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 źºƔƳŻřƶºƧLJŚºŝźƠƇŢƗŚſŶƴƳŚƯƹŹřŵƹŵźƷźŧřæçŢƗŚſ ŹŵP=ååçŵƺŝŹřŵƾƴƘƯƽŹŚƯōƑŚŰƫŻřƶƬŘƀƯƲƿřƶƧŵřŶƳ 400 300 200 100 0 H00 H12 H24 H36 H48 H00 H12 H24 H36 H48 ƲƟƹźěƺŤƧƽƹŹřŵƢƿŹżţŻřŶƘŝƾŬƴſŵŹŵŢſřŹŢưſƹŢſřƲǀƯƺƬĮƯƲǀƀƨǀƳƺƬƟƽƹŹřŵƢƿŹżţŻřŶƘŝƾŬƴſŵŹŵĚģŢưſëŹřŵƺưƳ *P<ååêŢſřƵŶƃƵŵřŵƱŚƄƳHŚŝƱŚƯŻŶƃŚŝƾƯ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ ŵŹŵƹśŚƸŤƫřźŧřƽƶƘƫŚƐƯ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 źºĭƶƳŚƄºƳƦºƿƱřƺƴƗƶŝ ƲƿŻƹźǀţƹźŤǀƳƽźǀĭƪƨƃŚƷƲǀƧƺŤǀſ 8 ŢǀƫƺŝŚŤƯƱŵƺŝƪǀųŵƩŚưŤůřŻřƾƧŚůŢƿźŤǀƳƾƀƧřźěŵƺūƹ ŦŰŝ ƾƀºƧřźěŶƿŚƀºƧřźěƺºſƶºƧŵřŵƱŚƄºƳ źºƋŚů ƽƶƘƫŚƐƯ ŵŹŵŹŵƽźºĮƿŵƶºƘƫŚƐƯŹŵæë ŶºƃŚŝƾºƯŢºƿźŤǀƳƾƀƧřźě ƲƟƹźěƺºŤƧƹƲǀƯƺƬĮƯƲǀƀƨǀƳƺƬƟƽƹŹřŵƹŵƶƨƴƿřŚŝŵŵźĭƾƯ æìŢſřƵŶƃƵŶƿŵŢƿźŤǀƳ ƽŚºƷŻƹŹŹŵƹŹřŵƹŵźƷ ŵŹŵŶƋźŧřŶƳŵřŵƱŚƄƳŵƺųŻřŵŹŵ ƱƺųƱŚƿźūƂƿřżƟř ƶŝƱřƺţƾƯ ƵŵŚƯƲƿřšřźŧř ŻřŶƃƶŤųŚƴƃ ŚºěƞºƧŹŵŹƹōśŚƸŤƫřƪƯŚƗƱřƺƴƗƶŝƱŚƴƿĥřŹŚƧŻřƵŶƃƭŚŬƳř ƽŚěƽƶĤƴěŹŵƽŶƬūźƿŻšŹƺƇƶŝŢƿźŤǀƳƾƀƧřźěƢƿŹżţŚŝ ƢºƿŹżţƾƣŚƠºƇƪºųřŵšŹƺºƇƶŝƲǀſŚŤƯƹŶƴƿřŚƿƹƲǀěŚƨſƺƳ ƵŶºƿŵƾºƣƹźƗŢƄƳŻƹźŝƪŰƯŹŵƶƴǀƿƺƯƱƺųƱŚƿźūƂƿřżƟř ƽŚºěƞºƧŢƯŚŴƋŢſřƵŶƃƵŵŚƠŤſřśŚƸŤƫřŶƋŵŹřŶƳŚŤſř ŹŚºģŵƽŹřŵƾºƴƘƯŹƺºƏƶºŝŶƘŝƶƤǀƣŵ èå ŵƺƃƢƿŹżţƱřƺǀů æåƹêçæBWšƹŚºººƠŤƯƽŚºººƷŻƹŵŚºººŝƹŹřŵƢºººƿŹżţŻř ŶƿŚƀºƧřźěƺſƦºƿƱřƺƴƗƶŝŢƿźŤǀƳƾƀƧřźěơƺƟ ƽƶƘƫŚƐƯŹŵ ŶƋšřźŧřƶƧŵřŵƱŚƄƳŪƿŚŤƳŶƃƽźǀĭƵŻřŶƳřžǀƫƺƧŚŝƱřƺǀů ŜºūƺƯŢºƿźŤǀƳƾƀºƧřźěƶºƧŵƺºƃƾºƯƵŵŻŽŶºůŵƺƃƾƯ ƭƺſŢƗŚſŚţƩƹřŢƗŚſŻřŻƹŵƶŝƶŤƀŝřƹšŹƺƇƶŝƭźĭƺƬǀƧ śŚººƸŤƫřŜººūƺƯƁƺººƯƽŚººěƽƶººŬƴěŹŵCarrageenan ƂƷŚºƧƩŵŚºƘƯľŚºŞƿźƤţ śŚºƸŤƫřƂƷŚƧŻƹŵƲƿřŹŵƶƧƽŹƺƏ ƶŝ ƪǀƨƄºţƹŶƿŚƀºƧřƦºƿźŤǀƳŚºŝƩŚƨƿŵřŹƲƿřƂƴƧřƹŻřƪƇŚů ŵŹŵƱōŜººƣŚƘŤƯƹśŚººƸŤƫřƽƶººſƹźěŵŚººŬƿřŜººūƺƯŢººƿźŤǀƳ ƾƀƧřźěŻřƾƿŚěŵŹżǀƳƦǀţŚǀſŜƈƗƾŝźŬţŜǀſōŻřƪƇŚů ƂƷŚƧŹŵƾţƹŚƠŤƯšřźŧřŚƯř ŶƳŶƃŻŚƳĦǀƀƧřƺƬƨǀſŹŚƸƯ ŦƗŚŝ źŧƺºƯśŚºƸŤƫřŻƹźŝŹŵŢƿźŤǀƳƾƀƧřźěźŧřƶŝŚƄƯƾƿřƶƘƫŚƐƯŹŵ ƽƶºƘƫŚƐƯƦºƿŹŵŢºƟŚƿƂƷŚƧŶƘŝƽŚƷŻƹŹŹŵŚƯřLJŚŝƩƹř řŸºƫŵźƧƵŹŚƃř ŵŹŵŵŚŬƿřƹƾƣƹźƗŢƄƳŻƹźŝƹƶƴǀƿƺƯơƹźƗ ƽŚƷƹŹřŵƵŶƃƭŚŬƳřžǀƫƺƧŚŝŚěƞƧƽźǀĭƵŻřŶƳř ŶƃƵŵŚƠŤſř ƾºƴƘƿšřźºŧřƲºƿřƶºƤǀƣŵéêŚºţźƠºƇŻřžěƾƿřźŰƇƁƺƯ ƽƹŹřŵƦºƿƱřƺºƴƗƶºŝƂƿŚºƯŻōƲƿřŹŵƲǀſŚŤƯƹŶƴƿřŶƿŵźĭ ƽŚěƞƧƶŝƩƺƯƺƳŚƳ çååŚţæååŢƿźŤǀƳƾƀƧřźěźĭřŵƺƃƾƯ žºěƹŶƃƽźǀĭƵŻřŶƳřƽŶƬūźƿŻƢƿŹżţŻřŶƘŝƹƪŞƣƱřƺǀů ŶºƳŚƯƾƯƾƣŚŝƶƤǀƣŵèëåŚţŢƫŚůƲƿřƹŵƺƃƾƯƾƣƹźƗŢƄƳ ƽŚºěƞºƧŢƗŚſƶſƹƹŵƦƿŹŵƭźĭƺƬǀƧƽřŻřƶŝƭźĭƾƬǀƯ ƶºƴǀƿƺƯƱƺºųƱŚºƿźūƹƾºƣƹźƗŢƄƳƹŵźƷƂƿřżƟřŜūƺƯ ƽřŻřƶºŝƭźºĭƾºƬǀƯêŚţåêBWźƿŵŚƤƯŻřƲǀěŚƨſƺƳśŚƸŤƫř ƱŚºƴǀūřŹŚƧ ƢºƿŹżţæíŵƺºƃƾƯƦƿĥƺƫƺţŚěśŚƸŤƫř ƽƶſƹźě ŢºſřƵŶǀºſŹźŨƧřŶºůƶŝƭźĭƾƬǀƯêŻƹŵŚŝƹŢƃřŵƂƿřżƟř ƪǀƨƄºţƲƿŻƹźºǀţƹźŤǀƳLJƺưƘƯŢƫŚůƲƿřŹŵ ŵƺƃƾƯƾƘƋƺƯ ƲǀěŚƨººſƺƳźţLJŚººŝŻƹŵŚººƯřŢººſřƲǀººſŚŤƯƹŶƴƿřŻřƾººƃŚƳ ƁƺºƯŹŵƵŶƷŚƄºƯƪºŝŚƣśŚƸŤƫřŵŚŬƿřƶƧŵƺƃƾƯƵŵŻŽŶů ƶºŝŲºſŚěƾºƴŰƴƯƶºƧŵƺŝƱōŻřƾƧŚůƾſŹźŝƲƿřŪƿŚŤƳŵŹřŵ ŚºŝŵřŻōƽŚºƷƩŚºƨƿŵřŹƲǀºŝƂƴºƧřƹƮǀºƳřŵƾºƯƶºƧŹƺºƏƱŚưƷ ƾŝŚºƸŤƫřŶƋŲſŚěŹřŶƤƯƂƿřżƟřŚŝƶƧƽŹƺƏ ƶŝŢſřƮưƿżƧŚƯ ŵŚºŬƿřƽřƶƘƿŚºƋƦǀţŚǀºſŜƈºƗƽƶǀůŚƳŹŵźĭřƶƧƾţŹƺƇ æêŶŝŚƿƾƯ ľLJŚºưŤůřŢºſřŢºƿźŤǀƳƾƀºƧřźěƪǀƨƄţźĭƶƳŚƄƳƶƧŵŵźĭƾƯ ƽźºŤưƧƾŝŚƸŤƫřŶƋźŧřƭźĭƺƬǀƧƽřŻřƶŝƭźĭƾƬǀƯæåBW æîŢºſřŢƿźŤǀƳƾƀƧřźěŶƿŚƀƧřźěƺſƽźǀĭƪƨƃŻřƾƧŚů ƽřŹřŵŹřƹƾưƸººſƾººƴŰƴƯƦººƿšŹƺººƇƶººŝƲǀěŚƨººſƺƳŹřŶƤƯ ŹŵŵƺƃƾƯŢƿźŤǀƳƾƀƧřźěƽźǀĭƪƨƃŜūƺƯŶƿŚƀƧřƦƿźŤǀƳ ƂƷŚºƧ ƾŝŚƸŤƫřŶºƋŲºſŚěźţLJŚŝŹřŶƤƯŹŵŚƯřŶŝŚƿƾƯƂƿřżƟř ƵŶºƃƆŴƄºƯŵƺºƃƾƯ ŢƿźŤǀƳƾƀƧ řźěƪǀƨƄţŜūƺƯƮǀƴƧ ŢºſřƵŵřŵƱŚƄºƳƮǀƤŤƀƯźǀƛƽƶƤƿźƏƶŝƵŶƃƭŚŬƳřšŚƘƫŚƐƯ ƭŚºŬƳřźºţŵƹŻƽŵƺºŞƸŝŶºƳƹŹƱřƺºūƽŚƷƁƺƯŹŵƾƫƹŶƳŹřŵ ƾƿřźŰºƇƁƺºƯƽŚºěƞƧŹŵƵŶƃŵŚŬƿřśŚƸŤƫřŹŵŶƃŚŝƾƯ ƭŻLJƽźŤƄºǀŝƱŚºƯŻƽŵƺºŞƸŝƽřźºŝƲƀºƯƽŚƷƁƺƯƶƧŢſř ŶƿŶƃŵŹŵƽƵŶƴƴƧŵŚŬƿřƽŚƷŹƺţŚƿŶƯŻřƾƨƿŶƿŚƀƧřźěƺſƶƧ ƪǀƨƄºţƂƿřżºƟřŻřƾƧŚºůŶºƳřƺţƾºƯƶƫŚƀºƯƲºƿřƹŵźºǀĭƾƯ ƱŶººƃŵřŻōƾƿřźŰººƇƁƺººƯƽŚººěƭŵřƱƺººģƽŚººƷƶƳŚƄººƳ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ 9 ƱřŹŚƨưƷƹƾƯŶƤƯũźƿř ŵƺºŞƳŹřŵƾƴƘƯrofecoxib Śŝ śŚƸŤƫřƹŵŹŵƂƷŚƧŚƯřŶƳŶƃ źºƧŷšŚƤǀƤŰţŹŵçåŶƃŚŝźǀěƽŚƷƁƺƯ ŹŵŚƷŶƿŚƀƧřźěƺſ ƹŶºƳŹřŵŻŚƳĦǀƀƧřƺƬƨǀſŹŚƸƯŹŵƽřƶŝŚƄƯźŧřŚƷƹŹřŵƽƶưƷƶƧ ŢºƬƗƶºƧŢºſřƵŶºƃŢºŝŚŧ ƱřƺǀůƽŚěƞƧŹŵŵŹŵƹśŚƸŤƫř ŵŹřŵƾƳřƺºųƮºƷŚƯƽƶƘƫŚƐƯŚŝƑŚŰƫƲƿřŻřƂƷƹĦěƲƿřçç ƂƷŚºƧƅƺƈºųŹŵƾţƹŚºƠŤƯźºŧřƾºƫƹŢſřźŝřźŝŚƷƱōŻƹŵ Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 ƽƹŹřŵŹŚºƸģŻřƶºƨƳōŚºŝŶƴƷŵƾƯƱŚƄƳŵƺųŻřŵŹŵƹśŚƸŤƫř ƽƹŹźººŝƾŝŚººŴŤƳřźǀƛŹƺººƏƶººŝƲǀººſŚŤƯƹŶƴƿřƽƹŹřŵơƺººƟ ŶºƳŹřŵƾŝŚŴŤƳřźŧřźĮƿŵƽŚƷƹŹřŵƹŶƴƧƾƯźŧřŻŚƳĦǀƀƧřƺƬƨǀſ ŚºŝƢǀƤŰţƲƿřšƹŚƠţƲǀƴĤưƷŢſřźŤƄǀŝƲǀſŚŤƯƹŶƴƿřźŧřŚƯř ƱŚºƯŹŵƽƵŹƹŵƩƺƏŹŵšƹŚƠŤƯƽŚƷŻƹŵƱŵźŝŹŚƧƶŝŚƯƢǀƤŰţ ŢºŝŚŧŻƹŵƦºƿŻřƱŚºƯŹŵƽƵŹƹŵƩƺƏŹŵŚƯƶƧ ƽŹƺƏ ƶŝŢſř ŻƹŵŻřƵŵŚƠŤºſřƶƧŢſřƵŵřŵƱŚƄƳƶƘƫŚƐƯƲƿřƮƿŵƺưƳƵŵŚƠŤſř žºěŢºſřƵŶºƃƾƸūƺºţƪºŝŚƣŹƺƏƶŝŵŹŵŹŚƸƯŜūƺƯLJŚŝ ƶŝŚƷƽŹŚưǀŝƾųźŝŹŵƶƧƵŵŹƲƿřŻřƽŚƷƹŹřŵźŧřƾſŹźŝƭƹżƫ šŶºƯŹŵƽŵƺºŞƸŝŵŚŬƿřƱŚƨƯřŵƺƃƾƯƝźƈƯƾƳLJƺƏšŶƯ ŵŻŚſƾƯŚǀƸƯřŹźŤưƧƱŚƯŻ ƽźǀĭƶŬ ǀŤƳ ŹřŶºƤƯŚºŝƾºŤůŢºƿźŤǀƳƾ ƀºĩřźěƱƺºģƾƿŚƷŶƿŚƀĩřźěƺſ ĨºƿĥƺƫƺţŚěśŚºƸŤƫřŵŚºŬƿřŹŵƮºƸƯƪƯŚƗĨƿ ŶƳřƺţƾ Ư ƾŗżū ƱŚºƯŹŵƶǀƫƹřšŚƗŚſŹŵ NSAIDsƽŚƷƹŹřŵ ŵŹŵŶƋźŧřŶƃŚŝ źºŧř ƱŚºƯŹŵ ƾƳŚºƿŚěšŚƗŚſŹŵƶŤƟŹƶŤƟŹƲĪǀƫ ŢſLJŚŝŹŚǀƀŝ ƽƹŹřŵƹŵźººƷƶººĪƴƿřŚººŝŵřŵƱŚƄººƳƽźǀĮưƄººģƂƷŚººĩƹŹřŵ źºŧřŚºƯřŶºƴĩƾ ºƯŹŚºƸƯřŹçŻŚƳĦǀƀĩřƺƬĪǀſżŤƴſNSAIDs ƶºŝƶºūƺţŚºŝŶƳŵřŵƱŚƄƳŵƺųŻřŵŹŵƪưŰţƑŚŰƫŻřƾţƹŚƠŤƯ ŚºƷƽ ŹŚºưǀŝŻř ƽŹŚǀƀºŝƱŚºƯŹŵŹŵ NSAIDsƽŚƷƹŹřŵƶĪƴƿř ƶºŤƟźĭŹŚºĩƶºŝƲƯżºƯƽŚºƷśŚºƸŤƫřƹŶǀŗƺţŚƯƹŹŢ ƿźţŹōŶƴƳŚƯ ƶºūƺţƹŹřŵšŶƯŻřŹŵšřźŧřƶŝƶĩŶƴĩƾ ƯśŚŬƿřřŸƫŵƺƃƾ Ư ŵƺƃƽřƵĦ ƿƹ źĪƄţƹźƿŶƤţ ƽĥƺººƫƺºƿżºǀƟƹƾºưǀƃƺºǀºŝƂººŴŝŻřƶƬǀººſƹƲ ºƿřƶºŝ ŵŚºŬƿřŹŵŢºƿźŤǀƳƾƀºƧřźěƆųLJŚºŝŚºƷŶƿŚƀƧřźěƺſźŧř ƵŶƃ ƾƬºƇř ƪºǀƫŵ ƱřƺºƴƗƶºŝ ƲƿŻƹźºǀţƹźŤǀƳ ƪǀƨƄţ źƯřƲƿřƾƬƇř ƮǀƤŤƀƯŹƺƏƶŝ źƋŚůƂƷƹĦě ŶƃŚŝƾƯ ŢƿźŤǀƳƾƀƧ řźěŵƺūƹ śŚƸŤƫřŵŚŬƿřŢƸūƵŚĮƄƿŚƯŻōŹŵƵŶƃżŤƴſŢƿźŤǀƳƾƀƧřźěŻř źƿŚºſƹƢºǀƤŰţƲºƿřřŸƫŵƺŝƵŵƺưƳƵŵŚƠŤſřŵŹŵƱōŜƣŚƘŤƯƹ ƽŶƿŚƀºƧřźěƺºſƶƧŵŻŚſƾƯƆŴƄƯŮƋřƹŹƺƏ ƶŝ šŚƤǀƤŰţ ŜºūƺƯƥŶºƳřźƿŵŚºƤƯŹŵƾŤůŶƳřƺţƾƯŢƿźŤǀƳƾƀƧřźě ŶƴƳŚƯ źºŝƶºŤƟŚƿƭŚºŬƳřƂƷƹĦºěŹŵŵŵźºĭŵŹŵƹƦƿĥƺƫƺţŚěśŚƸŤƫř ƹŚºĭŢƟŚŝŹŵŢůřźūŵŚŬƿřŻřžěƶƧŶƃƵŶƷŚƄƯƹŚĭƽƹŹ ŹřŶºƤƯƆǀŴƄºţŢºƸūŹŵƱƺųƭźſŻŚƴǀƧƲǀţřźƧƂŬƴſƹ ƹƲǀƯƺººƬĮƯƲǀƀººƨǀƳƺƬƟƽŚººƷƹŹřŵŚººŝƱŚººƯŹŵƹŢººůřźū ƽƹŹřŵƹŵƶºƧŢºſřƵŶºƃƵŶƷŚƄƯƱƹŻŚţƺŝƪǀƴƟƹ ƲƟƹźěƺŤƧ ƹƶºūƺţƪºŝŚƣŹƺºƏƶºŝƱƹŻŚºţƺŝƪǀƴƟƹƲǀƯƺƬĮƯƲǀƀƨǀƳƺƬƟ ŚºƯřŵƺŝƵŶƃŻŚƴǀƧƲǀţřźƧŹřŶƤƯƱŶƯōƲǀƿŚěŜūƺƯƽŹřŵƾƴƘƯ ƶºƘƫŚƐƯƲƿřçæŢſřƵŵřŶƳƱŚƄƳƾƸūƺţƪŝŚƣźŧřƲƟƹźěƺŤƧ ŚºƷƹŹř ŵƶŝŚƄºƯźºŧřƮƀǀƳŚƨƯŵƺūƹŚŝƾŤůƶƧŢſřƵŵřŵƱŚƄƳ ƶºƘƫŚƐƯŹŵŵŹřŶºƳƾƳřŶºƴģźǀŧŚţźŧƺƯƱŚƯŹŵŶƳƹŹŹŵƹŹřŵƦƿ źºŧřƶºƧŶºƃƆŴƄºƯƾŝƺºųƶºŝƶƫŚƀºƯƲºƿřżǀƳƶŤƟŚƿƭŚŬƳř ƽřƶºƘƫŚƐƯŹŵŶƳŵƺŝšƹŚƠŤƯƲǀƀƨǀƳƺƬƟƹƲƟƹźěƺŤƧƽŚƷƹŹřŵ Rofecoxib, Celecoxib, NimesulideƽŚºƷƹŹřŵźŧřźĮƿŵ ŶƃƵŵřŵƱŚƄƳƁƺƯƽŚěƽƶĤƴ윌ƸŤƫřƽƹŹźŝƲǀſŚŤƯƹŶƴƿřƹ śŚºƸŤƫřƂƷŚºƧŜºūƺƯƭźºĭƺºƬǀƧŹŵƭźĭƾƬǀƯæåŻƹŵŚŝƶƧ ŚºŝŶºƇŹŵçæërofecoxibŚºŝŶºƇŹŵéåëƱřżºǀƯƶŝŵŹŵƹ Śºŝ ŶºƇŹŵ ëé ƹ nimesulide Śŝ ŶƇŹŵçåè celecoxib ƂƷŚºƧƭźĭƺƬǀƧŹŵƭźĭƾƬǀƯçêŻƹŵŚŝŵƺŝƵŶƃƲǀſŚŤƯƹŶƴƿř ŶƇŹŵçìrofecoxibŚŝŶƇŹŵêåëå ƱřżǀƯƶŝ ŵŹŵƹ śŚƸŤƫř ŚºŝŶƇŹŵíëæ ƹnimesulide Śŝ ŶƇŹŵèècelecoxib Śŝ Celecoxib, NimesulideƽƹŹřŵƶºſŶƃƵŶƷŚƄƯƲǀſŚŤƯƹŶƴƿř ŵŹŵƹśŚºƸŤƫřƂƷŚƧŜūƺƯƽŹřŵƾƴƘƯŹƺƏƶŝƲǀſŚŤƯƹŶƴƿřƹ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ ŵŹŵƹśŚƸŤƫřźŧřƽƶƘƫŚƐƯ ƮƿŹřŵřŹźĪƄţƩŚưĩŶƳŵƺưƳ 10 ƵŚĮƄºººƳřŵƾĪºººƃżĜƯřŵƽƵŶĪƄºººƳřŵ ƹƭƺºººƬƗƽƵŶĪƄºººƳřŵ ƽŹŚºººƿřŹŚºººƯƢºººǀƤŰţƭŚºººŬƳřƪºººůřźƯŹŵƶºººĩƶºººǀƯƹŹř Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 References oxide related therapeutic phenomenon. Naunyn 1- Sadeghi-Hashjin G, Folkerts G, Henricks PAJ, Schmiedebergs Arch Pharmacol. 2003; 368: Rmuijsers RB, Nijkamp FP. Peroxynitrite in 26-32. airway diseases. Clin Exp Allergy. 1998; 28: 7- Farshid A, Sadeghi-Hashjin G, Ferdosi GF. 1464-73. Histopathological 2- Sadeghi-Hashjin G. Folkerts G, Jhenricks PA, peroxynitrite on the lungs and trachea of rabbits. et Eur Respir J. 2002; 20: 1-3. al. Peroxynitrite induces airway studies on the effect of hyperresponsiveness in guinea-pigs in vitro and in 8- Harms CA, Lewbart GA, Swanson CR, vivo. Am J Respir Crit Care Med. 1996; 153: Kishimori JM, Boylan SM. Behavioral and 1697-701. clinical pathology changes in koi carp(cyprinus 3- Sadeghi-Hashjin G, Folkerts G, Henricks PA, carpio) subjected to anesthesia and surgery with Vandeloop G, Dik IE, Nijkamp FP. Relaxation of and without intra-operative analgesics. Comp guinea pig trachea by sodium nitroprusside:cyclic Med. 2005; 55(3): 221-26. GMP and nitric oxide not involved. Br J 9- Shadan F, Motamedi F. [Translation] Ganong Pharmacol .1996; 118: 466-70. VF. Physiology. Tehran: Ghehr pub; 2000. 4- Pool AJ, Whipp BJ, Skasick A, Malavi J, Bland 10- Coruzzi G, Menozzi A, Dobrilla G. Novel JS. Axford serum cortisol reduction and abnormal Non-steroidal anti inflammatory drugs. Current prolactin and CD+4/CD8+ T-Cell response as a Drug Targets Inflam Allergy. 2004; 3: 43-61. result of controlled exercise in patient with 11- Yoon JB, Kim SJ, Hwang SG, Chang S, Kang rheumatoid lupos SS, Chun JS. Non steroidal anti inflammatory muscle drugs inhibits nitric oxide induced apoptosis and arthritis erythematosus and despite systemic unaltered energetics. J Rheumatol. 2004; 43: 43-8. dediffer 5- Jozsef L, Zouki C, Petasis NA, Serhan CN, independent of cyclooxygenase activity.J Biol Filep JG. Lipoxin A4 and aspirin-triggered Chem. 2003; 278: 15319-25. 15-epi-Lipoxin 12- MacAllister CG, Morgan SJ, Borne AT, Pollet A4 inhibitory peroxynitrite entiation of articular formation, NF-B and AP-1 activation, and IL-8 RA.Comparison of gene expression in human leukocytes. Proc phenylbutazone, flunixin Natl ketoprofen in horses. J Am Vet Med Assoc. 1993; Acad Sci USA. 2002; 99: 1366-71. 6- Fernandez P, Guillen MI, Ubeda A et al.Nitric adverse chondrocytes effects meglumine, of and 202: 71-7. ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ ƱřŹŚƨưƷƹƾƯŶƤƯũźƿř Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 11 13-Ridger VC, Greenacre SA, Handy RL, et al. nociception in the rat. Br J Pharmacol. 1997; 122: Effect of peroxynitrite on plasma extravasation, 1083-8. microvascular blood flow and nociception in the 19- Salvemini D, Wang ZQ, Bourdon DM, Stern Rat.Br J Pharmacol.1997; 122: 1083-8. MK, Currie MG, Manning PT. Evidence of 14- Chipkin RE, Latranyi MB, Iorio LC, Barnett peroxynitrite involvement in the carrageenan- A. Determination of analgesic drug efficacies by induced rat paw edema. Eur J Pharmacol. 1996; modification of the Randall and Selitto rat yeast 303: 217-20. paw test. J Pharmacol Methods. 1983; 10: 223-9. 20- Salvemini D,Wang ZQ, Stern MK, Currie 15- Khakpoor M, Shafiei M, Rostami P, Sadoghi MG, Misko TP. Peroxynitrite decomposition M, on catalysts therapeutics for peroxynitrite-mediated karanginan in flammation in rat. J of Iran Biology. pathology. Proc Natl Acad Sci USA. 1998; 95: 1384; 18: 18-25. 2659-63. 16- Ting ST, Earley B, Hughes JM, Crowe MA. 21- Pyorala S, Laurila T, Lehtonen S, Leppa S, Effector ketoprofen, lidocaine local anesthesia,and Kaartinen L. Local tissue damage in cows after combined xylazine and lidocaine caudal epidural intramuscular anesthesia during castration of beef cattle on containing phenylbutazone, flunixin, ketoprofen stress responses, immunity, growth, behavior. J and metamizole. Acta Vet Scand. 1999; 40: 145- Anim Sci. 2003; 81: 1281-93. 50. 17- Liu T, Knight KR, Tracey DJ. Hyperalgesia 22- Suleyman H, Demircan B, Karagoz Y, due Oztaºan N, Suleyman B. Anti-inflammatory Mahmoodian to nerve M. Noskapin injury-role of effect peroxynitrite. administration of preparations Neuroscience. 2000; 97: 125-31. effects of selective COX-2 inhibitors. Pol J 18- Ridger VC, Greenacre SA, Handy RL, et al. Pharmacol. 2004; 56: 775-80. Effect of peroxynitrite extravasation,microvascular on blood plasma flow and ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ 12 Downloaded from zums.ac.ir at 3:18 IRST on Thursday March 9th 2017 ŵŹŵƹśŚƸŤƫřźŧřƽƶƘƫŚƐƯ ÕÕƱŚŤƀƯŻÓÖƽƵŹŚưƃ ÎÔƽƵŹƹŵƱŚŬƳŻƾƳŚƯŹŵƾŤƃřŶƸŝšŚƯŶųƹƾƨƃżěƭƺƬƗƵŚĮƄƳřŵƾƄƷƹĦěƾưƬƗƽ ƶƬŬƯ