Medical quality radiation r€sistantplasticized poly(vinyl chlońde)

lJ^l{ll^l{A śWERZ ]\'loTYslA
lnduśrń] chcmEty l{c5.ikh lń*ifuic
DcPłnncni ol PolymcE rd N'aic
ul Rydygi.li s' 0l-793 [hśiw
c
nuil balLara'{vicŹjnotlsńoid'Ppl
Medical quality radiation r€sistantplasticized
poly(vinyl chlońde)
5unńi!y Th.cff!Ćr01ńodili.atiololPliłicizerłndśabilŻdsyś.ń5od
c
od Efi
o
n !e\is ran.c oI
'h
włs
śudicd sa
fl!\ibh Pvc rmpositn'rś nr frcdici l łPpl]. jo ns
ifadiłtld i'r i lincł a(elsłol L^E 13/9 oI
PLes Lvcle
cy
EiolÓgi.al
ch.n]ol and nc.hinisl.
P]ishcjzcd Pvc cofuloltn ns o1fiodilicd ldńUlaiions and comPircd
thos. oI stafdird mcdi.il Eridc .
'l''''rl'.
m.'nl1'rh''T'
ofo '''arr'l
K.y Hotds. pliłi.izld Pvc' n'cdi
lvtll
'"
'''''l'ł'
miho| of Peloxid!' Ćarbonyl łBj hydnxlLFeNFs Thn
Eid iatcd .ompos (D\ le rrl
nunbcr of rcsc'lch śudr.shi\c L'.cu nri lc
doraEc tim! or
ofdisp.Śabh ńedful d.vit\, Wh
to
lcncoxidc) o! drccxposurc ro ion
of lhesc mctlrods has
dśadvinhgśIh limt ib us.'
The m.d]od !śi']g !tlrylcn. olid
tine consumi'1gand cxp.nsn'colc rd
Ą'sr
bc
Nłmvd.thy
tclilaniśUscd,.a(
(jd
gis
bk.n to
lclducsnr llrcdcvic.si|d
RNnt]y thcnrcdici] rdusty hJs bĘuI toshilt ilr
ihzition hchniqnc or disposiblc cdi.al dcvircs
iron ct]rylcn. ox]dc to ionńij]! n
cr.clhnt ind norc cffi. icni bioloEicil le l$s cxpeNjv!
rd Lcs iimc{nnunins Drcrhod ir 3t.
Howev.r, when liPolal t] i.niŻi'llJ radlłti (.l
ganrmł nys ol llo.ton b!ańs) Fv
undcirablc.lr sesilrPh),si.rl,.l]eri. andbn']dlji.łl
*
\'hich
ir.rcpoNiblc
ńłiośsu.h
sjon
ind oXidiiion'
posiuor
thc
,Ą
I t_vpcs
(o
oi PVc hansloi.
.listind .lis.oloratio| of Pvc con
N ma(a tvpi.al*crjliz ionLroscoI5kct
nai!
irraLrirtio
rn
lor sc!{n
is dKoloGhon,
al icnds to
!
].fPVc
dłkcn o' io
tun]
l!llo\' Dlli'lg
rvc,(Djusabddoublcl,ondsalclolm.il
onsiblclordE.olot
coEFostiońs oqgcn il$ cuscs rhc iol
m
radLaiioo rcsishu.c of l
n2 161. rhc kcy idci or a[ or r
pn*!dŃ. clfNt tiv usns conrPotrnds (':i o'gi|.ti|
mcrciPioa. e*!x and dilfelot tvPśoi.RDIti. rofr
pounds), \4'icl, idas an cncrsy E
changc ol P.lyms PrcPfftics L]nn un.id]l mośo'
^
Prore
Th. cff.ds or brsi.
!.mpomnb
vri(n,s
aLrdj
riois Ncrc Pcnnancnflv skr ied af
f iblf; rhcresuuhas iotb!o1 unif
k, thosud], of IlUiŻh!c
^(ordi'rg
di
PlashcżcE 2 cdrylhc\}'l Phlhłlatc (D!l'lj) iNl cll
xt1iscd so),b!ai oil (Eso), ŃDm(nnv !{] ]n D.,l(iL
.omPositiotrs, i5 cl'csjlc irśibilż
{mcłiotr dIl'cl
PVc l]7]
p kd gÓod.olou!śrL]il
'!om vłnd ovcri l] proPcn ics b th.
rrorhcropi|ion, rhcariph i. plr*
tspc onnak!dlai łońati.o|.5 n2' ]3]
tio| of alkyl !*cr of ł]lPr Ł
h.Xy])adipare (DoA), i5
Thci|tln.
Plinl.iŻs
imProvs rr'.!$niaf..of thcs. rn
The Pvc Plaśnzcd rqth Do^ c\h]Llb booEilnl rd
Ćhcnjcal Prc},c ies ł(oŁ]ing b thc ljuropca| Phłlnm
llcł *ab]lizfls
can hlvc
ł maiol cILd
on th!
p0.
ł]5
ńdnal łtrm|lilit cr/zl {abilizing sydcn a|onc js
N*Poycdul !.o !h io Pro!i.l. i idjatio| śibililyof
(lthcabo(eca/unŚy*.nŚholls
.rtiir thcdNolonhonotrhcPvc
'em,kiLt.inrpro!.
drri,,! irndiiriun L19l 11 cn b. dL'c to thc ib,Lity or rhc
*.hilvcl t] !cFlł.! the libilc d]
s(uF Thus, u' su.h a ohpo5irio
adiarior $abir y of
(h. tytc
ls ftn gn'.n)
Thc }rrcsĆ|t rvo* i]so.oncm\ ih
ndi]hoI r.s]sii|.c ol t i*icjZ.,l lj\lc
/' frodiń.
ifts irndiatiol and incubłiion (dcnotcd "aficl
T.'Bilc proPdli$
Lvefu
ń65!fud
MFR varucs wcre dctcrmin.d by usinE rl TR
tonctcr.t l90ic \rith5kglord.
ThonoBlavjm.ti. a.łlyliśwłs p.rlorm&1
Th. simplG or PVC conposiiiorr I erc snspcn.rar in
nrw o
irrhahr 7nan
rd
(bÓth
05 mnr thick|!śł/r{DńL
!cd!Ćin8 and
sEdcr {
=
70
(An
l,Liś]ciŻĆIs: d].2.cth] hĆ!yl pit]ri]itĆ (DtHl')
lts!roL All (Lli,Ls), iris.2-cthyLh.\y1 himcllititc
shL,irjzc* ca/zn
cpoitrlizeds)\beitriil
t innl]
{lh
nDń tcnPda
ńn
thc DFt.rń]s th arc mcdńg rhc IU
n,ots Ior mc.lj.il 4,pli. ,o's i,
fv(: lolinvrls 70sNI, mlJral
ll sĄ, ło.laW.k, f oliId)
ai
or hirhcr
f
a. s.Nr
rv
Phol,lr łn.]ł'cPor],ln
ol!
sUn.fu of Iilń,
ri. omPounds' cxprcsscd
20cm ot iqucous
wivclc|llhnng.of
L]v
ihc m]].
c*nd and by uv absoiption
20 290ńn't.spftlivdv
Thc sruduml.hatrges of Pvc wu
FilmŚ .' 0 ] ńń th]Ćk l'!r.
spcltc.oPy'
,I
PVC
Pl.P
ld
br-
i
ohpo\iri(r.
if bichlommethatu
lhcwiv. ntńb.!n|Ec oa]700_]61]1]cm .oocsFo|i_
Tl'. .olÓ!l .ffc.ś .in bcqułntifiślL]y us']rg hrhftP
stcPha| high{Pod mjxcr Nłs us.!]
P\'c^ pol'dd vith
rhg
Pliłi.j7.i
i'llj..'nposł(n\ $ct hońogc
crrlds
t)rur't
b
'nix
rhe tuulE
Ż
rcnpcntuc 150/r55lr60'c
d'!
to drc
fon
aM yollÓlvne* lndc\cs ( l4Ą1 wc.c
plaqua ,!hrc rd bli.k wcrc us.d
banŚFaieit ń]ms and onl], rclativ
p.r.
TyPicil .onnr.ńal nldi.al graJ! Pla i.izld
of DEI,H
nlm tcmtsihr. rvrth in.Lcdron
..hrito, L/\E l3le i do!! or2r kcy ,J d,!n ituu
bitŃ L20hol'sal5 t iosiftllat
annri r r.npmhtr.(.3.i"rJ) n6l
Thc .hcmlciL' biologi.łl' mc.hinril ]d ihoma1
(M/{) of PVC on\rosirro's rlcrc d.tcrnirer:
hcn!. rn d ń tion (dcnolcd "blforc kłl,
_iłcn'idiatio| (d.nolĆd'afb ].'),
PlałtiŻ8 ]
lvc
]n of
ci/zns.lkaM 35'x of cFo!d]z.,l $vb.ón uli5ś'bi
l'cN this *aLilving sv*c( ]s !łncd '!tiŃi!l śilrl
T\a' serics or Pvc composition
scics
l:
.olt niĘ ńÓdilild
(m\turc of Pla*jĆi2ds i . DEPll
+
Pla*ki2il1tj Śys!trr
ToTll) in,l
*iłji
syś.m(śiŃ.]d
sabilizer and .ostJt iliz$s) łnd śandald Pliśi.lzcl
funbur a.omłłic grouPs and .an absorb thc cl.iia-
othc' rcn{cacting Iońs 14,17l1.ś' high moleĆllal
weight plasticizer TOTM) (series I),
on adas ndicł] rd Hclscilcns.ls as w.lla5
radiation prote.bre slrowirg thc abiht-v oi blo.kEs or
dolble bÓndś fom ion
u0 Gcms lI
wfth
cośibili
Thc amollb oI additivls \rm .hosn en'piri!żlv
Thc sclmtd no,lń.d Pvc .ońpÓ
rt{":ul,!!
ńdiatjon st.ilizcd ńcd jcal d 'i.c
risslcs haing conhd wrh thcm Thcrcforc thc mrSration iMcx ollow nolc.ular subśi
trad w.s nsed as a nre.ri']g tGt or propc ics orimdi-
tela8ei',3onlow
.!s lxtad
iŚ p($ĆńiĆd
(
F
iIJ
r )
nł scledĆd .omFdś itiois
|a. Absorb (c .ftcl ]Eidńhon
onl}' ina.ascd flom
olrpGihon wirh nrodrficd
(Fig. li) ind.omPosiiion of
abour 0 r5 tu about 030 io!
phshorr syścm(]V'D_])
scrics n with nodificd shbilizcr syścm,.ontaining ilt
smallłmou|t oI.ośabiljzo wiih Ph€nolic and amido
8roups (lvID D (rig' 1b)'
rd irradiation (curvcs
Adkńnd
ed..frpositiÓNal
3)
.dmPÓun.ls lń rhis casc wis h]ghc!
ońPalison vjth t]]c.omPsitjon oIsoics ll _ MD.2
luv ibsorbincc or vitcr c\bact ib
sPediv.ly), but fol both lhGcsinrPlś hlghc th th
pĆm led by thc ncdi.'l lcqurcnrc|ts (Uv ab6mb ]a
ńax 0'3) Thc i(cPlłb]c rcsulb' nom mcdi.al Poijt of
v]cv (<0.3), werc obtain.d fol the .omFositions ł'D
MD.4 and ]VID.5 .onlai'Ńg the d
'
adiĘ Śimlltaneously as |lcl sóvcngcc komPounds
lvnh eFoxy intl imldo 8rouPs) and rłdi.i]s dli.tivaloB
(rmpoundswirh phenolicErorps). Fi8!rc I pre{nh,as
r .xanplĆ ÓfPoPd ońPsińoń
ing.omPcihon MD ł (Fj! l.)
lntcrcśingl' thc łmount ol'cduc gs'bśanG (Fi]!
2) ldrchcd ijtow cI f'om illinidiłl.dand thln łge'l
ńlns of sc .s Il kolum| 3), meas
nl
.ł r /{l&/ó'|r.4?4itdl!lałd''łrjyc!.'lpośil łl
łr)
MD 2,k) MD !;1 bl1ołl',) a1tl.,
nlbt ttlrt,.tohr tiĘ
3 ^|Dr'łb)
ą,'dn1Ś E|npn| Pln tr phk
Iuos
ncct ihc rcquirements s.i
ro
Thc .oloLl lcsi$an.e ńeasureń
lowneŚ indcxofifadiitcd films, vhi.h is a śrcng ru|c
tiÓń of.osabihaE rnhni (Fi8' 3)' lMrgasinE .on.e|.
bation of blo.ko$ or dorbrr bond
.als'scavcngas signlli.antly iedmcd thc .hinFe ir yel
li*.
] Lłił.Ii]tri:']t |.lnli,
rł,J h..3
tLt h Lx.ddhl
liL l l,lńd {!l']|!
oi ł].
hn!
n]lii]i])l d
h.lrlt t. 1 ,ttt
l]s .]. Fr/n 5Jłd' !i Pv. ł
t\itrDs l h.nrtk.2 rtr.r,'.3 4rrh-tn
h'
bn.tof rndFrcd.oDrpo\iri(D!\ irsoob!.rvd (FiF.r)
r:T ]|l sp(ha.r\an]PLr rlrD r (rj!
słf ol !n'bo|vl Ai]UF |'il.]
h.i Plr.ś his b.o o.łłr
'l'h. nuŚ losŚ oI.trlY
ló n' s
nPl. i!'D
tc.łi..l.ll
.hangll nr
]]
i\io
o!.li
Ij]]cł .nncn.]' (F]g'
ildJńlcd
(]a{ lnNbat&l) a
lŚ.!|]F 5)'łN1onLYn.
F.!Fired P\'c
b\jc
t.dn dv)
j
l2
j|
o)Po
ś.Ć|Nt]r,.lt!rś
b.l.'l .onpo1tio|ś (TiLnc ]) Th.r
F|d. on rh|.ońPo\ ($ o] nudicd mD]Pl$
riLt.s
()
r rlrr Thcd robhN.lnT
afu
ŚmńłVcd ir
t!
5
16trt)hr!
u
tthlurrt
MD
iĘ fhefuopod]
n]
iĘ ldlg otJd with'e]ln!frcnś
blq,d Thc hds
2
madc ol thiśPvc
iś'
ol thcr PhysidognlproPc
Thc r.sulE rndicir!
selrd.d ad
.f ńocnry oI lhcmil śabilizci allo\!
ti.izld Pvc that rśisłed25 Lc]' d.5c5 of
ih
cl(bo| bcim
.cptabl. Physiologi..l }'oPc ]s ind oloul
w's posńlc
aPPli.ilion ol ih.
''l syśeml20l
mĘGiic śabilzhg
Thc resulh s!33!* rhat a pi(,p.rlv b
śiLty)
a lidĘhon śJbLc PVc.on
'chievc
opcd sabilizin8 sy*cm plovidcs s
io rh.PvC.nd pmbabl, pliys ilrc.ombi,r.il tulc.s th.
ihcmal Pm.csilg śabili"ftand as thc jadńho| śiL,'
lizo.s well łs a ŚbPpel oIaubołilyii. Pośrladhho|
plo.cscs o(lrtinE i'' Pvc Th. ł
ol po*nndiafud F!Ó.crso\ .f \'oll
P.sitio'T showcd thit rhc .onc!ńta
weiBht r€anic subsbnc$ hżchltl l
śo!i8e
l
iłh th. ProlonEahon of
cońFolhon
PrPstiś
'hc
vcrv ńr|ortinl
d^lso
n.ltvis.ciyolPli*rlŻcd
T''s t0,^'lr'fu lllPD full
,/i. tuJmr.,, ((BN), 6nrt
chemi.al pmpeńis duńng iccelcRicd łgcing sim!]iL
in8 the twGyoars bng sbraFe łi Imm tmPcnturc
'nre *tńt of
Pctifadiłrion PrmsŃs Ćl' as jni
gratn,ń ińdex of low ńole.llal subś
conju8it.d doublc bonds chansc or do! and d.hydr.
chlo mtion isr€duccd lo a(cptibbńnrjńuff
cizcd Pvc onpositiolś \, rhc
ld
li*ań.c of plaŚli
bJ
No
L'\]csimP]ś
sli' cdłłil,.L[, s.i.ł
''lI 1u9t
lxrN
l5
A /łu alł oł/ s. lhł Eł!
t
Wot]'ńsb
L
'
B hil
z''
sabtń$