تاثیر تزریق داخل صفاقی نانو ذرات مولیبدن بر تست‌های عملکردی

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The Effect of Intraperitoneal Injection of Molybdenum Nanoparticles on Renal Functional
Tests in Rat
Mohseni M1, Dadashi K2, Heidari A3
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1
Dept .of Food and Drug Control, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
2
Dept .of Biotechnology and Nanotechnology, Faculty of Medicine, Student Research Committee, Zanjan University of Medical Sciences, Zanjan,
Iran
3
Dept .of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Corresponding Author: Heidari A, Dept. of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan
University of Medical Sciences, Zanjan, Iran.
E-mail: [email protected]
Received: 12 Oct 2014
Accepted: 25 Jun 2015
Background and Objective: With the industrialization of nanotechnology and increase in application of
nanoparticles in modern technology, carrying out research on nanoparticles and their effects on health is
necessary. So, this study was aimed to assess acute toxicity of molybdenum nanoparticles on serum
biochemical function of kidney in rat.
Materials and Methods: In this experimental study, 24 male rats were randomly divided into four groups of
six: a control group and tree treatment groups. The control group received 1 ml distilled water and the
treatment groups received intraperitoneal injection of 5, 10and 15 mg/kg of molybdenum nanoparticles of
10 nm daily for 28 days. After the last dose, blood samples were taken from all groups and levels of Blood
Urea Nitrogen (BUN), creatinine, total protein and albumin were measured and then the groups were
compared.
Results: The serum levels of BUN and creatinine in the group receiving 15 mg/kg dose decreased
significantly compared to the control group (P<0.05). The serum albumin level in the groups receiving 10
and 15 mg/kg doses showed significant decrease compared to the control group (P<0.05). The serum total
protein level in the groups receiving 5, 10 and 15 mg/kg doses showed significant decrease compared to the
control group (P<0.05).
Conclusion: The results of this study showed that molybdenum nanoparticles of 10 nm at these
concentrations decrease creatinine and BUN levels of serum.
Key word: Molybdenum nanoparticles, Blood Urea Nitrogen, Creatinine, Toxicity
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